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| 1 | Diagnostic non-invasive model of large risky esophageal varices in cirrhotic hepatitis C virus patients显示文摘AIM To build a diagnostic non-invasive model for screening of large varices in cirrhotic hepatitis C virus(HCV) patients. METHODS This study was conducted on 124 post-HCV cirrhotic patients presenting to the clinics of the Endemic Medicine Department at Mansoura University Hospital for evaluation before HCV antiviral therapy: 78 were Child A and 46 were Child B(score ≤ 8). Inclusion criteria for patients enrolled in this study was presence of cirrhotic HCV(diagnosed by either biopsy or fulfillment of clinical basis). Exclusion criteria consisted of patients with other etiologies of liver cirrhosis, e.g., hepatitis B virus and patients with high MELD score on transplant list. All patients were subjected to full medical record, full basic investigations, endoscopy, and computed tomography(CT), and then divided into groups with no varices, small varices, or large risky varices. In addition, values of Fibrosis-4 score(FIB-4), aminotransferase-to-platelet ratio index(APRI), and platelet count/splenic diameter ratio(PC/SD) were also calculated.RESULTS Detection of large varies is a multi-factorial process, affected by many variables. Choosing binary logistic regression, dependent factors were either large or small varices while independent factors included CT variables such coronary vein diameter, portal vein(PV) diameter, lieno-renal shunt and other laboratory noninvasive variables namely FIB-4, APRI, and platelet count/splenic diameter. Receiver operating characteristic(ROC) curve was plotted to determine the accuracy of non-invasive parameters for predicting the presence of large esophageal varices and the area under the ROC curve for each one of these parameters was obtained. A model was established and the best model for prediction of large risky esophageal varices used both PC/SD and PV diameter(75% accuracy), while the logistic model equation was shown to be(PV diameter ×-0.256) plus(PC/SD ×-0.006) plus(8.155). Values nearing 2 or more denote large varices.CONCLUSION This model equation has 86.9% sensitivity and 57.1% specificity, and would be of clinical applicability with 75% accuracy. | Hatem Elalfy Walid Elsherbiny Ashraf Abdel Rahman Dina Elhammady Shaker Wagih Shaltout Ayman Z Elsamanoudy Bassem El Deek | 2016 | World Journal of Hepatology2016,8,24: | 5 |
| 2 | Efficient non - viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells显示文摘 | Pasha Z Haider H Ashraf M | 2011 | PloS one2011,6,23: | 1 |
| 3 | Evaluation of diagnostic potential of Rv3803c and Rv2626c recom- binant antigens in TB endemic country Pakistan显示文摘 | Ashraf S Saqib M A Sharif M Z | 2014 | Journal of Immunoassay and Immunochemistry2014,35,2: | 1 |
| 4 | Selective leaching kinetics and upgrading of low-grade calcareous phosphate rock in succinic acid显示文摘 | ASHRAF M ZAFAR Z I ANSARI T M | 2005 | Hydrometallurgy2005,80,4: | 1 |
| 5 | A clinico- pathologic study of 82 intraoral minor salivary glandtumors显示文摘 | Jaafari-Ashkavandi Z Ashraf MJ Afandak N | 2011 | Iran Red Crescent Med J2011,13,9: | 1 |
| 6 | Three-dimensional speckle- tracking imaging for left ventricular rotation measurement: an in vitro validation study 显示文摘 | Zhou Z Ashraf M Hu D | 2010 | J Ultrasound Med2010,29,6: | 1 |
| 7 | Controlled release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method显示文摘 | Babar A Ashraf M | 2002 | Drug Dev Ind Pharm2002,28,2: | 1 |
| 8 | Transient behavior of heavy metals in soils during electrokinetic remediation显示文摘 | Ashraf Z Al-Hamdan Reddy Krishna R | 2008 | Chemosphere2008,71,5: | 1 |
| 9 | Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide 显示文摘 | Ashraf M Z Hussain M E Faehim M | 2004 | J Ethnopharmacol2004,90,1: | 1 |
| 10 | 查看详情显示文摘 | H Bronstein Z Chen R S Ashraf | | 0,,10: | 1 |
| 11 | 查看详情显示文摘 | R S Ashraf Z Chen D S Leem | | 0,,03: | 1 |
| 12 | Size of radialand ulnar artery in local population 显示文摘 | ASHRAF T PANHWAR Z HABIB S | 2010 | J Pak Med Assoc2010,60,10: | 1 |
| 13 | Sodium borohydride reduction of aromatic carboxylic acids via methyl esters显示文摘 | Saeed A Ashraf Z | 2006 | Journal of Chemical Sciences2006,118,5: | 1 |
| 14 | 查看详情显示文摘 | Z Chen M J Lee R Shahid Ashraf | | 0,,05: | 1 |
| 15 | A clinico-pathologic study of 82 intraoral minor salivary gland tumors显示文摘 | Jaafari-Ashkavandi Z Ashraf M J Afandak N | 2011 | Iran Red Crescent Med J2011,13,: | 1 |
| 16 | ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis 显示文摘 | Hasan Z Jamil B Ashraf M | 2009 | Plos One2009,4,4: | 1 |
| 17 | 3-dimensional speckle tracking ima- ging for left ventricular rotation measurement: an in vitro validation study显示文摘 | Zhou Z Ashraf M Hu D | 2010 | J Ultrasound Med2010,29,6: | 1 |
| 18 | Selective leaching kinetics of calcareous phosphate rock in lactic acid 显示文摘 | Zafar Z I Ashraf M M | 2007 | Chemical Engineering Journal2007,131,3: | 1 |
| 19 | Selective leaching kinetics and upgrading of low-grade calcareous phosphate rock in suecinie acid显示文摘 | Ashraf M M Zafar Z I Ansari T M | 2005 | Hydrometallurgy2005,80,2: | 1 |
| 20 | Processing a glass fiber reinforced vinyl ester composite with nanotube enhancement of interlaminar shear strength 显示文摘 | JIANG Z ASHRAF I ROGER C | 2007 | Composites Science and Technology2007,,67: | 1 |