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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Leaf respiration of show gum in light and dark interaction between temperature and irradiance 显示文摘 | ATKIN O K EVANS J R BALL M C | 2000 | Plant Physiology2000，122，： | 1 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | TGF - 13 in the context of an inflammatory cytokine milieu supports de novo differentia- tion ofiL- 17 producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，5： | 1 |
| 5 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 6 | TGF - beta in the context of an infla - mmatory cytokine milieu sup- ports de novo differentiation of IL - 17 - producing T cells 显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 7 | Joint optimization of maintenance and inventory policies for a simple system显示文摘 | Armstrong M J Atkins D R | 1996 | IIE Transactions1996，28，5： | 1 |
| 8 | Bacterial blights of snap beans and their control 显示文摘 | Webster D M Atkin J D Cross J E | 1983 | Plant Disease1983，67，： | 1 |
| 9 | TGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells 显示文摘 | VEHLHOEN M HOCKINGG R J ATKINS C J | 2006 | Immunity2006，24，2： | 1 |
| 10 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 11 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17- producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immtmity2006，24，2： | 1 |
| 12 | TGF-β in the context of an inflammatory cytokine milieu supportsde novo differentiation of IL-17-producing T cells 显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 13 | On the role of Cs, Cl and subsurface O in promoting selectivity in Ag/a- Al2O3 catalysed oxidation of ethene to ethene epoxide显示文摘 | Atkins M Couves J Waugh K C | 2005 | J Catal2005，235，1： | 1 |
| 14 | Chemical sequence control of beta-sheet assembly in macromolecular crystals of periodic polypeptides显示文摘 | Krejchi M T Atkins E D T Waddon A J | 1994 | Science1994，265，： | 1 |
| 15 | A PPAR-FGF1 axis is re- quired for adaptive adipose remodelling and metabolic homeostasis 显示文摘 | Jonker J W Suh J M Atkins A R | 2012 | Nature2012，485，7398： | 1 |
| 16 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 17 | Social implications of arsenic poisoning in Bangladesh 显示文摘 | Hassan M M Atkins P J Dunn C E | 2005 | Social Science & Medicine2005，61，： | 1 |
| 18 | The selective formation of neutral, heteroleptic zinc(Ⅱ ) complexes via self-discrimination of chiral bisoxazoline racemates and pseudoracemates显示文摘 | Takacs J M Hrvatin P M Atkins J M | 2005 | New J Chem2005，29，： | 1 |
| 19 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-produeing T cells显示文摘 | VELDHOEN M HOCKING R J ATKINS C J el al | 2006 | Immunity2006，24，2： | 1 |
| 20 | TGFbetain the context of an inflammatory cytokine milieu supports denovo differentiation of IL-17-producing T cells 显示文摘 | VELDHONE M HOCKING R J ATKINS C J | 2006 | Immuni-ty2006，24，2： | 1 |
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