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| 1 | Characterization of functional biliary pain and dyspeptic symptoms in patients with sphincter of Oddi dysfunction:Effect of papillotomy显示文摘AIM: To characterize functional biliary pain and other gastrointestinal (GI) symptoms in postcholecystectomy syndrome (PCS) patients with and without sphincter of Oddi dysfunction (SOD) proved by endoscopic sphincter of Oddi manometry (ESOM), and to assess the post- endoscopic sphincterotomy (EST) outcome. METHODS: We prospectively investigated 85 cholecystectomized patients referred for ERCP because of PCS and suspected SOD. On admission, all patients completed our questionnaire. Physical examination, laboratory tests, abdominal ultrasound, quantitative hepatobiliary scintigraphy (QHBS), and ERCP were performed in all patients. Based on clinical and ERCP findings 15 patients had unexpected bile duct stone disease and 15 patients had SOD biliary typeⅠ. ESOM demonstrated an elevated basal pressure in 25 patients with SOD biliary-type Ⅲ. In the remaining 30 cholecystectomized patients without SOD, the liver function tests, ERCP, QHBS and ESOM were all normal. As a control group, 30 ‘asymptomatic’ cholecystectomized volunteers (attended to our hospital for general cardiovascular screening) completed our questionnaire, which is consisted of 50 separate questions on GI symptoms and abdominal pain characteristics. Severity of the abdominal pain (frequency and intensity) was assessed with a visual analogue scale (VAS). In 40 of 80 patients having definite SOD (i.e. patients with SOD biliary typeⅠand those with elevated SO basal pressure on ESOM), an EST was performed just after ERCP. In these patients repeated questionnaires were filled at each follow-up visit (at 3 and 6 mo) and a second lookQHBS was performed 3 mo after the EST to assess the functional response to EST. RESULTS: The analysis of characteristics of the abdominal pain demonstrated that patients with common bile duct stone and definite SOD had a significantly higher score of symptomatic agreement with previously determined biliary-like pain features than patient groups of PCS without SOD and controls. In contrary, no significant differences were found when the pain severity scores were compared in different groups of PCS patients. In patients with definite SOD, EST induced a significant acceleration of the transpapillary bile flow; and based on the comparison of VASs obtained from the pre- and post-EST questionnaires, the severity scores of abdominal pain were significantly improved, however, only 15 of 35 (43%) patients became completely pain free. Post-EST severity of abdominal pain by VASs was significantly higher in patients with predominant dyspepsia at initial presentation as compared to those without dyspeptic symptoms. CONCLUSION: Persistent GI symptoms and general patient dissatisfaction is a rather common finding after EST in patients with SOD, and correlated with the presence of predominant dyspeptic symptoms at the initial presentation, but does not depend on the technical and functional success of EST. | László Madácsy Roland Fejes Gábor Kurucsai Ildikó Joó András Székely Viktória Bertalan Attila Szepes János Lonovics | 2006 | World Journal of Gastroenterology2006，12，42： | 33 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Human adult epidermal melanocytes cultured without chemical mitogens express the EGF receptor and respond to EGF显示文摘 | Gábor Szabad Bernadett Kormos Andor Pivarcsi Márta Széll Kornélia Kis Anna Kenderessy Szabó Attila Dobozy Lajos Kemény Zsuzsanna Bata-Cs?rg? | 2007 | Archives of Dermatological Research2007，，4： | 1 |
| 4 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 5 | The in vivo role of p38MAP kinases in cardiac remodeling and restrictive cardiomyopathy显示文摘 | Pu L Dimitrios G Attila K | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 6 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 7 | Gene-gene interac- tion of ACE I/D, endothelial nitric oxide synthase 4 a/b and ApoE does not affect coronary artery disease severity显示文摘 | Matyar S Acart ti rk E Attila G | 2014 | Adv Clin Exp Med2014，23，2： | 1 |
| 8 | Differential effects of cold, osmotic stress and abscisic acid on polyamine accumulation in wheat显示文摘 | Zita Kovács Livia Simon-Sarkadi Attila Sz?cs Gábor Kocsy | 2010 | Amino Acids2010，，2： | 1 |
| 9 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 10 | Apolipoprotein E polymorphism in childhood nephrotic syndrome显示文摘 | Noyan A Karabay Bayazit A | 2002 | Pediatr Nephrol2002，17，5： | 1 |
| 11 | Apolipoprotein E polymorphism in childhood nephrotie syndrome 显示文摘 | ATTILA G NOYAN A KARABAY BAYAZIT A | 2002 | Pediatr Nephrol2002，17，5： | 1 |
| 12 | Insertion/deletion polymorphism of the angiotensin converting enzyme gene in coronary artery disease in southern Turkey显示文摘 | Acarturk E Attila G Bozkurt A | 2005 | J Biochem Mol Biol2005，38，4： | 1 |
| 13 | Synthesis,characterization and gold loading of polystyrene-poly(pyridyl methacrylate) core-shell latex systems显示文摘 | Oláh Attila Hempenius Mark A Vancso G Julius | 2004 | European Polymer Journal2004，40，4： | 1 |
| 14 | Frost hardiness depending on carbohydrate changes during cold acclimation in wheat 显示文摘 | Attila V Ildiko K Gabor G | 1999 | Plant Science1999，1441，： | 1 |
| 15 | The influence of iron substitution to manganese on the physical properties of YMnO3 显示文摘 | Attila V Jacques N G Stephan F | 2006 | Solid State Sci2006，8，： | 1 |
| 16 | Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate显示文摘 | Attila Oláah Gáabor Pardavi Tibor Beláagyi Attila Nagy áAkos Issekutz Gamal E Mohamed | 2002 | Nutrition2002，，： | 1 |
| 17 | Effect of Ischemic Preconditioning on Rat Liver Microcirculation Monitored with Laser Doppler Flowmetry显示文摘 | Attila Szijártó Oszkár Hahn Gábor Lotz Zsuzsa Schaff Emilia Madarász Péter Károly Kupcsulik | 2006 | Journal of Surgical Research2006，，1： | 1 |
| 18 | TRP channels in the skin显示文摘 | Balázs I Tóth Attila Oláh Attila Gábor Sz?ll?si Tamás Bíró | 2014 | Br J Pharmacol2014，，10： | 1 |
| 19 | Gastric calcifying fibroustumor显示文摘 | Attila T Chen D Gardiner G W | 2006 | Can J Gastroenterol2006，20，7： | 1 |
| 20 | Perturbation of infinite networks of resistors 显示文摘 | Cserti J D6vid G Attila Pir6th | 2002 | Am J Phys2002，70，2： | 1 |
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