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| 1 | Effect of temperature on ascorbate peroxidase activity and flowering of Arabidopsis thalianaecotypes under different light conditions显示文摘 | Shubhangi D L Ken'ichi O Ayumi T | 2003 | J Plant Phys2003，160，： | 1 |
| 2 | Development of tissue-engineeredhuman periodontal ligament constructs with intrinsic angiogenicpotential显示文摘 | Nobuhiro N Ayumi H Nao O | 2009 | Cells Tissues Organs2009，190，6： | 1 |
| 3 | Pedigree analysis of the sika deer ( cervus nippon ) using microsatellite markers 显示文摘 | AYUMI O HIDETOSHI B TAMATE | 2000 | Zoological Science2000，17，： | 1 |
| 4 | Four new triterpenoids from Maytenus ilcifolia 显示文摘 | Ayumi O Yoji I Meiko N | 2004 | J Nat Prod2004，67，： | 1 |
| 5 | Stage-specific sagittal spinopelvic alignment changes in osteoarthritis of thehip secondary to developmentalhip dysplasia显示文摘 | Tetsuhito O Takuya F Ayumi K | 2007 | Spine2007，32，26： | 1 |
| 6 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 7 | Premature coronary-artery atherosclerosis in systemic lupus erythematosus显示文摘 | Yu A Annette O Ayumi K | 2003 | N Engl J Med2003，349，25： | 1 |
| 8 | Effects of long-term treatment with ranirestat,a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats显示文摘 | Ayumi O Akihiro K Fumihiko T | 2013 | J Diabetes Res2013，10，1： | 1 |
| 9 | Ring closure of carbon nanotubes显示文摘 | MASAHITO S AYUMI K JUNKO O | 2001 | Science2001，293，5533： | 1 |
| 10 | Identification and ge-nomic structure of chemosensory proteins (CSP) andodorant binding proteins(OBP) genes expressed in foreleg tarsi of the swallowtail butterfly Papilio xuthus 显示文摘 | Katsubisa O Masasuke R Ayumi Y | 2008 | Insect Biochemistry and Molecular Bi- ology2008，38，： | 1 |
| 11 | Replacement of dietary fish oil with olive oil in young yellowtail Seriola quinqueradiata:effects on growth,muscular fatty acid composition and prevention of dark muscle discoloration during refrigerated storage显示文摘 | Ayumi S O Fumiaki T Tomomi H | 2008 | Fisheries Science2008，74，： | 1 |
| 12 | Premature coronar-yartery atherosclerosis in systemic lupus erythematosus显示文摘 | Yu A Annette O Ayumi K | 2003 | N Engl J Med2003，349，25： | 1 |
| 13 | Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure显示文摘 | Ayumi F Yosuke O Takahisa T | 2003 | Int Med2003，42，7： | 1 |
| 14 | Effects of heat stress on muscle mass and the expression levels of heat shock proteins and lysosomal cathepsin L in soleus muscle of young and aged mice显示文摘 | YOSHITAKA O SUMIO Y AYUMI G | 2012 | Molecular and Cellular Biochemistry2012，369，12： | 1 |
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