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| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | The influences of attitudes, beliefs and label information on perceptions of reduced-fat spread 显示文摘 | Aaron J I Mela D J Evans R E | 1994 | Appetite1994，22，： | 1 |
| 3 | Growth of Grain Boundary Precipitates in Al-4% Cu By Interracial Diffusion 显示文摘 | Aaron H B Aaronson H I | 1968 | Acta Metall1968，16，6： | 1 |
| 4 | Dynamic relationship of left-ventricular dyssynchrony and contractile reserve in patients undergoing cardiac resynchronization therapy显示文摘 | Stankovic I Aarones M Smith HJ | 2013 | Eur Heart J2013，，： | 1 |
| 5 | Diazepam pharamacokinetics from preclinical to phase Ⅰ using a bayesian population physiologically based pharmacokinetle model with informative prior distributions in winbugs 显示文摘 | Gueorguieva I Aarons L Rowland M | 2006 | Journal of Pharmacokinetics and Pharmacodynamics2006，33，5： | 1 |
| 6 | Control of an interconnected power system:a time delay approach显示文摘 | Dan I Aaron F S Jean-Michel Dion | 2002 | IMA Journal of Mathematical Control and Information2002，19，1： | 1 |
| 7 | Soot oxidation: dependence upon initial nanostructure显示文摘 | Randy L Vander Wal Aaron I Tomasek | 2003 | Combustion and Flame2003，134，1： | 1 |
| 8 | Diabetic neuropathy pathogenesis and therapy显示文摘 | Aaron I | 1999 | The American Journal of Medicine1999，107，213： | 1 |
| 9 | Effects of suspen- ded sediment characteristics and bed sediment transport on streambed clogging 显示文摘 | Kristin J R Aaron I P Jianhong R | 2005 | Hydrological Processes2005，，19： | 1 |
| 10 | Tuberculosis in HIV-infected patients:a comprehensive review显示文摘 | Aaron L Saadoun D Calatroni I | | 0，，05： | 1 |
| 11 | Tuberculosis in HIV-in fected patients: a comprehensive review 显示文摘 | Aaron L Saadoun D Calatroni I | 2004 | Clin Microbiol In- fect2004，10，5： | 1 |
| 12 | Statin therapy and levels of thrombosis risk factors in a healthy population: the multi-ethnic study of atheroselerosis显示文摘 | Nathan BA Pamela I Aaron F | 2010 | Blood2010，116，： | 1 |
| 13 | Identification and expression of Toll-like receptors 1 - 10 in selected bovine and ovine tissues 显示文摘 | Moira M Aaron I | 2005 | Vet Immunol lmmunopathol2005，109，2： | 1 |
| 14 | Tuberculosis in HIV infected patients:a comprehensive review显示文摘 | Aaron L Saadoun D Calatroni I | | 0，，05： | 1 |
| 15 | Tuberculosis in HIV-infected pa- tients : a comprehensive review显示文摘 | Aaron L Saadoun D Calatroni I | 2004 | Clin Microbiol Infect2004，10，5： | 1 |
| 16 | Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment显示文摘 | Dirany A Aaron ES Oturan N Sirés I Oturan AM Aaron JJ | 2011 | Anal Bioanal Chem2011，400，： | 1 |
| 17 | Tuberculosis in HIV-infected patients:a comprehensive review显示文摘 | Aaron L Saadoun D Calatroni I | 2004 | Clin Microbiol Infect2004，10，5： | 1 |
| 18 | Lumping of whole-body physiologically based pharmacokinetic models显示文摘 | NESTOROV I A AARONS L J ARUNDEL P A | 1998 | J Pharmacokinet Biopharm1998，26，1： | 1 |
| 19 | Thin membrane n- ephropathy:a clinical-pathological study 显示文摘 | AARON I SMITH P S DACIES R A | 1989 | Clin Nephrol1989，32，： | 1 |
| 20 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
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