维普期刊资源整合服务平台（V6.5）

30篇 您的检索式：作者名="Abagyan"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca ²⁺_{在 CaSRs 7 transmembrane (7TM ) 以内的 o} 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca ²⁺_o-binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。	Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos	2016	Cell Research2016，26，5：	2
2	Mapping the active Site of CD59显示文摘	YU J ABAGYAN R DONG S	1997	J Exp Med1997，185，4：	1
3	Defining the CD59-C9 Binding Interaction显示文摘	HUANG Y QIAO F ABAGYAN R	2006	J Biol Chem2006，281，27：	1
4	Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation显示文摘	WU Y W GOODY R S ABAGYAN R	2009	J Biol Chem2009，284，13：	1
5	TSG101 may be the prototype of a class of dominant negative ubiquitin regulators显示文摘	Koonin EV Abagyan RA	1997	Nat Genet1997，16，：	1
6	Pocketome: an encyclopediaof small-molecule binding sites in 4D 显示文摘	Kufareva I Ilatovskiy A V Abagyan R	2011	Nucleic Acids Res2011，40，：	1
7	GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex 显示文摘	KATRITCH V RUEDA M LAM P C YEAGER M ABAGYAN R	2010	Proteins2010，78，1：	1
8	Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists 显示文摘	WU Bei-li CHIEN E Y MOL C D FENALTI G LIU Wei KATRITCH V ABAGYAN R BROOUN A WELLS P B1 F C HAMEL D J KUHN P HANDEL T M CHEREZOV V STEVENS R C	2010	Science2010，330，6007：	1
9	High-Throughput Docking for Lead Generation显示文摘	Abagyan R Totrov M	2001	Current Opinion Chemical Biology2001，5，4：	1
10	Flexible ligand docking to multiple receptor conformations: a practical alternative 显示文摘	Totrov M Abagyan R	2008	Current Opinion in Structural Biology2008，18，2：	1
11	Flexible ligand docking to multiple receptor conformations : a practical alternative显示文摘	Totrov M Abagyan R	2008	Current Opinion in Structural Biology2008，18，：	1
12	Computational prediction of atomic structures of helical membrane proteins aided by EM maps 显示文摘	Kovacs JA Yeager M Abagyan R	2007	Biophys J2007，93，6：	1
13	Consistent improvement of cross-docking results using binding site ensembles generated with elastic network normal modes显示文摘	Rueda M Bottegoni G Abagyan R	2009	Journal of Chemical Informational Modeling2009，49，：	1
14	The contour-buildup algorithm tocalculate the analytical molecular surface 显示文摘	Totrov M Abagyan R	1996	Journal ofStructural Biology1996，，：	1
15	ICM: a new method for protein modeling and design applica- tions to docking and structure prediction from the dis- torted native conformation 显示文摘	ABAGYAN R TOTROV M KUZNETSOV D	1994	Comput Chem1994，15，5：	1
16	Defining the CD59-C9 binding in- teraction 显示文摘	Huang Y Qiao F Abagyan R	2006	Journal of Biological Chemistry2006，，27：	1
17	XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification 显示文摘	Smith C A WantEJ O'mailleG Abagyan R Siuzdak G	2006	Analytical Chemistry2006，78，3：	1
18	Energy strain in three-dimensional protein structures 显示文摘	Abagyan R	1998	Folding & Design1998，3，：	1
19	A new method for protein modeling and design:Applications to docking and structure prediction from thc distorted native conformation显示文摘	Abagyan R Totrov M Kuznetzov D		0，，05：	1
20	High-throughput docking for lead generation显示文摘	Ruben Abagyan Maxim Totrov	2001	Current Opinion in Chemical Biology2001，，4：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示