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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 4 | Challenges in laser-assisted milling of titanium alloys显示文摘Several detailed studies have comprehensively investigated the benefits and limitations of laser-assisted machining(LAM)of titanium alloys.These studies have highlighted the positive impact of the application of laser preheating on reducing cutting forces and improving productivity but have also identified the detrimental effect of LAM on tool life.This paper seeks to evaluate a series of the most common cutting tools with different coating types used in the machining of titanium alloys to identify whether coating type has a dramatic effect on the dominant tool wear mechanisms active during the process.The findings provide a clear illustration that the challenges facing the application of LAM are associated with the development of new types of cutting tools which are not subjected to the diffusion-controlled wear processes that dominate the performance of current cutting tools. | Matthew S Dargusch Tharmalingam Sivarupan Michael Bermingham Rizwan Abdul Rahman Rashid Suresh Palanisamy Shoujin Sun | 2021 | International Journal of Extreme Manufacturing2021，3，1： | 3 |
| 5 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 6 | The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia显示文摘 | Abdul S Brown BH Milnes P | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 7 | Expression of nitric oxide synthase isoforms in normal ventilatory and limb muscles显示文摘 | Hussain S N El-Dwairi Q Abdul H ussain M N | 1997 | J Appl Physiol1997，83，2： | 1 |
| 8 | Activities of some soil enzymes in different land use system after deforestation in hilly areas of west Lampung, South Sumatra, Indonesia显示文摘 | Abdul K S Kimura M A | 2000 | Soil Science2000，80，： | 1 |
| 9 | Weatherability of coated fabrics as roofing material in tropical environment显示文摘 | ABDUL R H CHUA C S TOYODA H | 2004 | Building and Environment2004，，39： | 1 |
| 10 | The pH dependence of ionic activities and total dissolved concentration of copper and cadmium in soil solution 显示文摘 | Abdul K S Philip H | 1998 | Geoderma1998，83，： | 1 |
| 11 | Laser welding of low carbon steel and thermal stress analysis 显示文摘 | Yilbas B S Arif A F M Abdul Aleem B J | 2010 | Optics & Laser Technology2010，42，5： | 1 |
| 12 | Activities of some soil enzymes in different land use system after deforestation in hilly areas of west Lampung, south Sumatra, Indonesia 显示文摘 | ABDUL K S KATAYAMA A KIMURA | 2000 | Soil Science2000，80，： | 1 |
| 13 | Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients显示文摘 | Juan Jesús Carrero Abdul Rashid Qureshi Paolo Parini | 2009 | J Am Soc Nephrol2009，20，3： | 1 |
| 14 | Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activa- tion coupled with GO/G1 phase cell cycle arrest 显示文摘 | MOHAN S ABDUL AB ABDELWAHAB SI | 2010 | J Ethno- pharmacol2010，131，3： | 1 |
| 15 | Reinforcement learning of iterative behavior with multiple sensors显示文摘 | Abdul S | 1994 | Journal of Applied Intelligence1994，4，5： | 1 |
| 16 | Implementation of dyna- mic evolution control of bidirectional DC-DC converter for inter- facing ultracapacitor energy storage to fuel-cell system 显示文摘 | AHMAD S S ABDUL H MOHAMED Y | 2010 | IEEE Transactions on Industrial Electronics2010，57，10： | 1 |
| 17 | Determination of organochlorine and pyrethroid pesticides in fruit and vegetables using solid phase ex- traction clean-up cartridges显示文摘 | Zawiyah S Yaakob B C M Nazimah S A H Abdul H | 2006 | J Chromatogr A2006，1127，： | 1 |
| 18 | A flexible technology for modified-release drugs:multiple-unit pellet system(MUPS)显示文摘 | Abdul S Chandewar AV Jaiswal S B | 2010 | J Control Release2010，147，1： | 1 |
| 19 | Oil palm trunk polymer composite:morphology,water absorption,and thickness swelling behaviors显示文摘 | Abdullah C K Jawaid M Abdul Khalil H P S | 2012 | Bioresources2012，7，3： | 1 |
| 20 | The effect of a compatibilizer on the mechanical properties and mass swell of white rice husk ash filled natural rubber-linear low density polyethylene blends显示文摘 | Ismail H Nizam J M Abdul Khalil H P S | 2001 | Polymer Testing2001，20，2： | 1 |
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