|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 3 | The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia显示文摘 | Abdul S Brown BH Milnes P | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 4 | A sensitive and reliable reverse transcriptase PCR enzyme-linked immunosorbent assay for the detection of human pathogenie viruses in bivalve molluscs 显示文摘 | Milne S A Gallagher S Cash P | 2007 | J Food Prot2007，70，6： | 1 |
| 5 | Effects of window size and thermal mass on comfort using an intelligent ventilation controller 显示文摘 | P La Roche M Milne | 2004 | Solar Energy2004，77，： | 1 |
| 6 | Discovery of benzothiazolederivatives as efficacious and enterocyte-specific MTP inhibitors显示文摘 | Vu C B Milne J C Carney D P | 2009 | Bioorganic&Medicinal Chemistry Letters2009，19，5： | 1 |
| 7 | The fate of absorbed and exogenous ammonia as influenced by forage or forage- concentrate diets in growing sheep显示文摘 | Lobley G E Weijs P J M Connell A Calder A G Brown D S Milne E | 1996 | British Journal of Nutrition1996，76，： | 1 |
| 8 | Amino acid nitrogen in atmospheric Aerosols:Occurrence,sources and photochemical modification显示文摘 | Milne P J Zika R G | 1993 | Journal of Atmospheric Chemistry1993，16，： | 1 |
| 9 | Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli显示文摘 | DIONYSIUS D A GRIEVE P A MILNE J M | 1993 | Journal of Dairy Science1993，76，： | 1 |
| 10 | Observations ofnonmethane hydrocarbons and oxygenated volatile or-ganic compounds at a rural site in the southeastern U-nited States显示文摘 | Riemer D Pos W Milne P | 1998 | Journal of Geophysical Research1998，103，28： | 1 |
| 11 | The origin of urinary aromatic compounds excreted by ruminants Ⅳ:The potential use of urine aromatic acid and phenol outputs as a measure of voluntary food intake显示文摘 | Martin A K Milne J A Moberly P | 1982 | British Journal of Nutrition1982，49，： | 1 |
| 12 | Maternal growth hormone treatment from day 35 to 80 of gestation alters nutrient partitioning in favor of uteroplacental growth in the overnourished adolescent sheep显示文摘 | Wallace J M Milne J S* Aitken R P | 2004 | Biol Reprot2004，70，5： | 1 |
| 13 | Modelling nutrient transport in Currency Creek, NSW with AnnAGNPS and PEST 显示文摘 | Baginska B Milne - Home W Cornish P S | 2003 | Environment Modeling&Software2003，18，： | 1 |
| 14 | The major and a minor class Ⅱbeta-chain (B-LB) gene flank the Tapasin gene in the B-F/B-L region of the chicken major histocompatibilil:y complex 显示文摘 | Jacob J P Milne S Beck S | 2000 | Immunogenetics2000，51，2： | 1 |
| 15 | Small moleule activators of sirt1 as therapeutics for the treatment of type 2 diabetes显示文摘 | MILNE J C LAMBERT P D SCHENK S | 2007 | Nature2007，450，7170： | 1 |
| 16 | Properties and intergranular phase analysis of a ZnO-CoO-Bi2O3 varistor 显示文摘 | ONREABROY W SIRIKULRAT N BROWN A P HAMMOND C MILNE S J | 2006 | Solid State Ionics2006，177，34： | 1 |
| 17 | The effect of (s, S) ordering policy on the supply chain显示文摘 | Kelle P Milne A | 1999 | International Journal of Production Economics1999，59，： | 1 |
| 18 | Bacillus thuringiensis δ-endotoxin: An improved technique for the separation of crystals from spores 显示文摘 | Milne R Murphy D Fast P G | 1977 | Journal of Invertebrate Pathology1977，29，2： | 1 |
| 19 | Synthesis of remote sensing approaches for forest carbon estimation: reporting to the Kyoto Protocol 显示文摘 | PATENAUDE G MILNE R DAWSON T P | 2005 | Environmental Science & Policy2005，8，2： | 1 |
| 20 | Discovery of benzothiazole derivatives as efficacious and entero- cyte-specifie MTP inhibitors 显示文摘 | Vu C B Milne J C Carney D P | 2009 | Bioorganic & Medic- inal Chemistry Letters2009，19，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员