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| 1 | Hepatocellular carcinoma with child Pugh-A Cirrhosis treated with stereotactic body radiotherapy显示文摘AIM To evaluate the control, survival, and hepatic function for Child Pugh(CP)-A patients after Stereotactic body radiotherapy(SBRT) in hepatocellular carcinoma(HCC).METHODS From 2009 to 2016, 40 patients with Barcelona Liver Clinic(BCLC) stages 0-B HCC and CP-A cirrhosis completed liver SBRT. The mean prescription dose was 45 Gy(40 to 50 Gy in 4-5 fractions). Local relapse, defined as recurrence within the planning target volume was assessed with intravenous multiphase contrast computed tomography or magnetic resonance imaging every 4-6 mo after completion of SBRT. Progression of cirrhosis was evaluated by CP and Model for End Stage Liver Disease scores every 3-4 mo. Toxicities were graded per the Common Terminology Criteria for Adverse Events(v4.03). Median follow-up was 24 mo.RESULTS Forty-nine HCC lesions among 40 patients were analyzed in this IRB approved retrospective study. Median tumor diameter was 3.5 cm(1.5-8.9 cm). Six patients with tumors ≥ 5 cm completed planned selected transarterial chemoembolization(TACE) in combination with SBRT. Eight patients underwent orthotropic live transplant(OLT) with SBRT as a bridging treatment(median time to transplant was 12 mo, range 5 to 23 mo). The Pathologic complete response(PCR) rate in this group was 62.5%. The 2-year in-field local control was 98%(1 failure). Intrahepatic control was 82% and 62% at 1 and 2 years, respectively. Overall survival(OS) was 92% and 60% at 1 and 2 years, with a median survival of 41 mo per Kaplan Meier analysis. At 1 and 2 years, 71% and 61% of patients retained CPA status. Of the patients with intrahepatic failures, 58% developed progressive cirrhosis, compared to 27% with controlled disease(P = 0.06). Survival specific to hepatic failure was 92%, 81%, and 69% at 12, 18, and 24 mo. There was no grade 3 or higher toxicity. On univariate analysis, gross tumor volume(GTV) < 23 cc was associated with freedom from CP progression(P = 0.05), hepatic failure-specific survival(P = 0.02), and trended with OS(P = 0.10).CONCLUSION SBRT is safe and effective in HCC with early cirrhosis and may extend waiting time for transplant in patients who may not otherwise be immediate candidates. | Shaakir Hasan Ngoc Thai Tadahiro Uemura Vijay Kudithipudi Paul Renz Stephen Abel Alexander V Kirichenko | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 2 |
| 2 | Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support显示文摘 | Arumugam V Routledge A Abell C | 1997 | Tetrahedron Lett1997，38，： | 1 |
| 3 | Population responses of hymenopteran parasitoids to the emerald ash borer (Coleoptera: Buprestidae) in recently invaded areas in Michigan显示文摘 | Bauer L S Abell K J van Drieshe R V | 2011 | Bio Control2011，57，2： | 1 |
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| 12 | Biology and clinical applications of pancreatic cancer stem cells 显示文摘 | Abel E V Simeone D M | 2013 | Gastroenterology2013，114，6： | 1 |
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| 14 | A phase Ⅱ study of 5-fluorouracil/cisplatinum in recurrent cervical cancer 显示文摘 | Kaern J Trop C Abeler V | 1990 | Acta Oncol1990，29，1： | 1 |
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| 16 | Beta-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer:, a study in 253 patients 显示文摘 | Kildal W Risberg B Abeler V | 2005 | EurJ Cancer2005，41，8： | 1 |
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| 18 | Robot-as si sted laparoscopic radical hysterectomy :comparison with total laparoscopic hysterectomy and abdominal radicalhysterectomy; one surgeon,s experience at the Norwegian RadiumHoapital显示文摘 | Sert M B Abeler V | 2011 | GynecolOncol2011，121，2： | 1 |
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