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| 1 | Cholesterol metabolism in cholestatic liver disease and liver transplantation:From molecular mechanisms to clinical implications显示文摘The aim of this review is to enlighten the critical roles that the liver plays in cholesterol metabolism. Liver transplantation can serve as gene therapy or a source of gene transmission in certain conditions that affect cholesterol metabolism, such as low-density-lipoprotein(LDL) receptor gene mutations that are associated with familial hypercholesterolemia. On the other hand, cholestatic liver disease often alters cholesterol metabolism. Cholestasis can lead to formation of lipoprotein X(Lp-X), which is frequently mistaken for LDL on routine clinical tests. In contrast to LDL, Lp-X is non-atherogenic, and failure to differentiate between the two can interfere with cardiovascular risk assessment, potentially leading to prescription of futile lipid-lowering therapy. Statins do not effectively lower Lp-X levels, and cholestasis may lead to accumulation of toxic levels of statins. Moreover, severe cholestasis results in poor micellar formation, which reduces cholesterol absorption, potentially impairing the cholesterol-lowering effect of ezetimibe. Apolipoprotein B-100 measurement can help distinguish between atherogenic and non-atherogenic hypercholesterolemia. Furthermore, routine serum cholesterol measurements alone cannot reflect cholesterol absorption and synthesis. Measurements of serum non-cholesterol sterol biomarkers- such as cholesterol precursor sterols, plant sterols, and cholestanol- may help with the comprehensive assessment of cholesterol metabolism. An adequate cholesterol supply is essential for liver-regenerative capacity. Low preoperative and perioperative serum cholesterol levels seem to predict mortality in liver cirrhosis and after liver transplantation. Thus, accurate lipid profile evaluation is highly important in liver disease and after liver transplantation. | Katriina Nemes Fredrik Aberg Helena Gylling Helena Isoniemi | 2016 | World Journal of Hepatology2016,8,22: | 6 |
| 2 | 等温淬火球墨铸铁的生产工艺显示文摘简单介绍了等温淬火球铁的性能特点与应用状况,分析了化学成分与合金化处理对等温淬火球铁性能的影响。重点介绍了等温淬火球铁的热处理工艺,指出在保证完全奥氏体化的同时应适当降低奥氏体化温度,同时应根据产品最终性能要求来选择等温温度及其保温时间。比较了ADI、普通球铁、低合金球铁的性能和金相组织,说明ADI具有的特殊奥贝双基体结构使得其具有高强度的同时有良好的塑性和韧性。 | Andy Plowman 周建荣 高杰 Lena Magnusson Aberg Cathrine Hartung | 2012 | 现代铸铁2012,32,A01: | 5 |
| 3 | 用贻贝壳内锶同位素比值作为酸化指标显示文摘为监测环境可能发生的变化,需要历史档案和能使我们解译其内容的适当方法。已经证实,天然同位素比值,如^(87)Sr/^(86)Sr比值是示踪过去和监测目前各种作用过程的良好手段。^(87)Sr/^(86)Sr比例的分布和变化使得锶同位素成为探测土壤-植被系统发展趋势的强有力手段。本研究项目对瑞典河流中的淡水珍珠贻贝壳Mar-garitifera进行了锶分析。结果表明,在1901~1990年这一研究期间内,^(87)Sr/^(86)Sr比值降低了,并有迹象表明,这些集水区域的土壤正在不断酸化。 | Goran Aberg Tonie Wickman Harry Mutvei 黄仲杰 | 1995 | 人类环境杂志1995,24,5: | 3 |
| 4 | Washout of grains from filtered sand and gravel materials显示文摘 | Aberg B | 1993 | Journal of Geotechnical Engineering1993,119,1: | 2 |
| 5 | Absorption of light in InP nanowire arrays显示文摘 | Nicklas Anttu Alireza Abrand Damir Asoli Magnus Heurlin Ingvar Aberg Lars Samuelson Magnus Borgstrom | 2014 | Nano Research2014,7,6: | 2 |
| 6 | From prolonging life to prolonging working life: Tackling unemployment among liver-transplant recipients显示文摘Return to active and productive life is a key goal of modern liver transplantation(LT). Despite marked improvements in quality of life and functional status, a substantial proportion of LT recipients are unable to resume gainful employment. Unemployment forms a threat to physical and psychosocial health, and impairs LT cost-utility through lost productivity. In studies published after year 2000, the average postLT employment rate is 37%, ranging from 22% to 55% by study. Significant heterogeneity exists among studies. Nonetheless, these employment rates are lower than in the general population and kidneytransplant population. Most consistent employment predictors include pre-LT employment status, male gender, functional/health status, and subjective work ability. Work ability is impaired by physical fatigue and depression, but affected also by working conditions and society. Promotion of post-LT employment is hampered by a lack of interventional studies. Prevention of pre-LT disability by effective treatment of(minimal) hepatic encephalopathy, maintaining mobility, and planning work adjustments early in the course of chronic liver disease, as well as timely post-LT physical rehabilitation, continuous encouragement, self-efficacy improvements, and depression management are key elements of successful employment-promoting strategies. Prolonging LT recipients' working life would further strengthen the success of transplantation, and this is likely best achieved through multidisciplinary efforts ideally starting even before LT candidacy. | Fredrik Aberg | 2016 | World Journal of Gastroenterology2016,22,14: | 2 |
| 7 | Near infrared spectroscopy for determination of mycotoxins in creals 显示文摘 | Petterson H Aberg L | 2003 | Food Control2003,14,4: | 1 |
| 8 | Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis显示文摘 | Aberg MA Ryttsen F Hellgren G | 2001 | Mol Cell Neurosci2001,17,3: | 1 |
| 9 | Protective and regenerative effects of the GH/IGFI axis on the brain显示文摘 | Isgaard J Aberg D Nilsson M | 2007 | Minerva Endocri- nol2007,32,2: | 1 |
| 10 | Biocompatibility and resorption of a radiopaque premixed calcium phosphate cement显示文摘 | Aberg J Henriksson HB Engqvist H | | 0,,: | 1 |
| 11 | Fish intake of Swedish male adolescents is a predictor of cognitive performance 显示文摘 | Aberg MA Aberg N Brisman J Sundberg R Winkvist A Toren K | 2009 | Acta Paediatr2009,98,3: | 1 |
| 12 | Fundamentals of Gas Containment in Unlined Rock Caverns显示文摘 | GOODALL D C ABERG B BREKKE T L | 1988 | Rock Mechanics and Rock Engineering1988,21,4: | 1 |
| 13 | Relationship between vitamin use,smoking,and nausea and vomiting of pregnancy显示文摘 | Lundberg G Aberg A | 2003 | Acta obstericicia et Gynecologica scandinavica2003,82,10: | 1 |
| 14 | Pulmonary cryptococcosis in patiemts without HIV infection显示文摘 | Aberg J A Mundy L M Powderly W G | 1999 | Chest1999,115,3: | 1 |
| 15 | Impaired glucose tolerance associated with adverse pregnancy outcomes: A population-based study in southern Sweden显示文摘 | Aberg A Rydhstroem H Frid Anders | 2001 | Am J Obstet& Gynecol2001,184,: | 1 |
| 16 | Context-dependent signal integration by the GLI code:The oncogenic load,pathways,modifiers and implications for cancer therapy显示文摘 | Aberger F Ruiz I Altaba A | 2014 | Semin Cell Dev Biol2014,,: | 1 |
| 17 | Regional Productivity Differences in Swedish Manufacturing显示文摘 | Aberg Y | 1973 | Regional and Urban Economics1973,3,2: | 1 |
| 18 | Tissue strength of structures involved in musculo- aponurotic layer stures in lnparotomg incisions 显示文摘 | Aberg C | 1976 | Acta Chir Seand1976,7,: | 1 |
| 19 | Presence of macroli- de resistance in respiratorg flora of HIV - Infected patients receiving either clarithromyein or azithromycin for Mycobacterium avium com- plex prophylaxis HIV显示文摘 | ABERG J A WONG M K FLAMM R | 2001 | Clin Trials2001,2,6: | 1 |
| 20 | Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4显示文摘 | Aberg E Perander M Johansen B | 2006 | J Biol Chem2006,,35: | 1 |