|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Local recurrence of eolorectal cancer:the problem,mechanism, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | Br JSurg1994，81，1： | 1 |
| 3 | Local recurrence of colorectal cancer:the problem,mechanism, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | BrJSurg1994，81，1： | 1 |
| 4 | Local recurrence coMrectal cancer: the problem, mechanism, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | Sr J Surg1994，81，1： | 1 |
| 5 | Local recurence of colorectal cancer:the probiem mechanism management and adjuvanttherapy显示文摘 | Abulafi AM WiUianms NS | 1994 | Br J Surg1994，81，： | 1 |
| 6 | Local recurrence colorectal cancer: the problem, mechanism, management and adjuvant:therapy显示文摘 | Abulafi AM Williams NS | 1994 | Br J Surg1994，81，1： | 1 |
| 7 | Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | Br J Surg1994，81，1： | 1 |
| 8 | Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy 显示文摘 | Abulafi AM Willians NS | 1994 | Br J Surg1994，81，1： | 1 |
| 9 | Local recurrence of colorectal cancer:the problem, mechanisms, management and adjuvant therapy显示文摘 | Abulafi AM Williams NS | 1994 | Br J Sur1994，81，1： | 1 |
| 10 | Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy 显示文摘 | Abulafi A N Wltiams N S | 1994 | Br J Surg1994，81，1： | 1 |
| 11 | Angiogenesis in malignancies of the female genital tract 显示文摘 | Abulafis O Triest WE Sherer DM | 1999 | Gynecol Onco11999，72，2： | 1 |
| 12 | Local recurrence of colorectal cancer:theproblem,mechanisms,management and adjuvant therapy显示文摘 | Abulafi A M Williams N S | | 0，，01： | 1 |
| 13 | Local recurrence of colorectal cancer : the problem, mechanisms, management and adjuvanttherapy 显示文摘 | Abulafi AM Williams NS | 1994 | Br J Surg1994，81，1： | 1 |
| 14 | Local recurrence of colorectal caner: the problem, mechanisms, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | Br J Surg1994，8，1： | 1 |
| 15 | Solitary pancreatic metastasis from a primary colonic tumor detected by PET scan显示文摘 | Matthew G. Tutton B.Sc. M.R.C.S. Mark George F.R.C.S. Mark E. Hill M.D. M.R.C.P. Mr. A. Muti Abulafi M.S | 2001 | Diseases of the Colon & Rectum2001，，2： | 1 |
| 16 | Local recurrence of eolorectal cancer: the problem, mechanisms, management and adjuvant therapy 显示文摘 | Abulafi AM Williams NS | 1994 | Br J Surg1994，81，1： | 1 |
| 17 | Local recurrence of colorectal cancer:the problem,mechanisms,management and adjuvant therapy显示文摘 | Abulafi A M Williams N S | 1994 | BrJ Surg1994，81，： | 1 |
| 18 | Does music reduce anxiety and discomfort during flexible sigmoidoscopy?A systematic review and meta-analysis显示文摘AIM To investigate the role of music in reducing anxiety and discomfort during flexible sigmoidoscopy. METHODS A systematic review of all comparative studies up to November 2016, without language restriction that were identified from MEDLINE and the Cochrane Controlled Trials Register(1960-2016), and EMBASE(1991-2016). Further searches were performed using the bibliographies of articles and abstracts from major conferences such as the ESCP, NCRI, ASGBI and ASCRS. Me SH and text word terms used included 'sigmoidoscopy', 'music' and 'endoscopy' and 'anxiety'. All comparative studies reporting on the effect of music on anxiety or pain during flexible sigmoidoscopy, in adults, were included. Outcome data was extracted by 2 authors independently using outcome measures defined a priori. Quality assessment was performed.RESULTS A total of 4 articles published between 1994 and 2010, fulfilled the selection criteria. Data were extracted and analysed using OpenM etaA nalyst. Patients who listened to music during their flexible sigmoidoscopy had less anxiety compared to control groups [Random effects; SMD: 0.851(0.467, 1.235), S.E = 0.196, P < 0.001]. There was no statistically significant heterogeneity(Q = 0.085, df = 1, P = 0.77, I2 = 0). Patients who listened to music during their flexible sigmoidoscopy had less pain compared to those who did not, but this difference did not reach statistical significance [Randomeffects; SMD: 0.345(-0.014, 0.705), S.E = 0.183, P = 0.06]. Patients who listened to music during their flexible sigmoidoscopy felt it was a useful intervention, compared to those who did not(P < 0.001). There was no statistically significant heterogeneity(P = 0.528, I2 = 0). CONCLUSION Music appeared to benefit patients undergoing flexible sigmoidoscopies in relation to anxiety and was deemed a helpful intervention. Pain may also be reduced however further investigation is required to ascertain this. | Arun P Shanmuganandan Muhammad R Sameem Siddiqui Nicholas Farkas Kiran Sran Rhys Thomas Said Mohamed Robert I Swift Al Mutaz Abulafi | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，5： | 1 |
| 19 | Local vecumence of colorectal cancer: the problem,mechanism,management and adjuvant therapy显示文摘 | Abulafi A M Williams N S | 1992 | Br J Surg1992，81，： | 1 |
| 20 | Local receurrence of colorectal cancer:the problrm mechanismsmanagement and adiunant theraph显示文摘 | Abulafi Am Williams NS | 1994 | Br J Surg1994，81，77： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员