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| 1 | 1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险显示文摘血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。 | Sousa GR Pober D Galderisi A Lv H Yu L Pereira AC Doria A Kosiborod M Lipes MA 刘莉 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 8 |
| 2 | ConservativeapproachinPeutz-JeghersSyndrome:Single-balloon enteroscopyandsmallbowelpolypectomy显示文摘AIM: To assess the usefulness of the balloon assisted enteroscopy in preventing surgical intervention in pa-tients with Peutz-Jeghers syndrome (PJS) having a small bowel large polyps. METHODS: Seven consecutive asymptomatic pts(age 15-38 years) with PJS have been collected; six under-went polypectomy using single balloon enteroscopy(Olympus SIF Q180) with antegrade approach using push and pull technique. SBE system consists of the SIF-Q180 enteroscope, an overtube balloon control unit(OBCU Olympus Balloon Control Unit) and a dispos-able silicone splinting tube with balloon(ST-SB1). All procedures were performed under general anesthesia. Previously all pts received wireless capsule endos-copy(WCE). Prophylactic polypectomy was reservedmainly in pts who had polyps > 15 mm in diameter. The balloon is inflated and deflated by a balloon control unit with a safety pressure setting range from-6.0 kPa to +5.4 kPa. Informed consent has been obtained from pts or parents for each procedure.RESULTS: Six pts underwent polypectomy of small bowel polyps; in 5 pts a large polyp > 15 mm(range 20-50 mm in diameter) was resected; in 1 patient with WCE negative, SBE was performed for previous surgi-cal resection of gastrointestinal stromal tumors. In 2 pts endoscopic clips were placed due to a polypectomy. No surgical complication have been reported. SBE with resection of small bowel large polyps in PJS pts was useful to avoid gastrointestinal bleeding and emergency laparotomy due to intestinal intussuscep-tions. No gastrointestinal tumors were found in sub-sequent enteroscopic surveillance in all seven pts. In order surveillance, all pts received WCE, upper en-doscopy, ileocolonoscopy every 2 years. No pts had extraintestinal malignant lesions. SBE was performed when WCE was positive for significant polyps(> 15 mm).CONCLUSION: The effective of prophylactic polyp-ectomy of small bowel large polyps(> 15 mm) could be the first line treatment for conservative approach in management of PJS patients. | Torroni F Romeo E Rea F De Angelis P Foschia F Faraci S Federici di Abriola G Contini AC Caldaro T Dall’Oglio L | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 3 | 瘦素通过醛固酮依赖机制,诱发肥胖雌性小鼠高血压和血管内皮功能障碍显示文摘肥胖是男性与女性心血管病的主要危险因素。然而,肥胖是否通过类似机制触发两性心血管病尚不清楚。在男性中,脂肪细胞因子瘦素通过增强交感神经活性,增加肥胖相关的心血管病。女性可分泌出高于男性3~4倍的瘦素,但未表现出与肥胖相关的较高的交感神经张力。 | 刘莉 叶鹏 Huby AC Otvos L Jr Belin de Chantemèle EJ | 2016 | 中华高血压杂志2016，24，3： | 5 |
| 4 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 5 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators 显示文摘 | Patel L Buckels AC Kinghom U | 2003 | Biochem Biophys Res Commun2003，300，2： | 1 |
| 8 | Molecular signatures in biopsy specimens of lung cancer显示文摘 | Borczuk AC Shah L Pearson GD | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 9 | Nerve grouth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals显示文摘 | Garofalo L Silva ABD Cuello AC | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 10 | Prognostic factors in patients with Htirthle cell neoplasms of the thyroid 显示文摘 | Lopez-Penabad L Chiu AC Hoff AO | 2003 | Cancer2003，97，5： | 1 |
| 11 | Immune-mediated mechanisms of parasite tissuesequestration during experimental cerebral malaria显示文摘 | Amante FH Haque A Stanley AC Rivera Fde L Randall LM Wilson YA | 2010 | J Immu-nol2010，185，6： | 1 |
| 12 | Global and genespecific promoter methylation changes are related to anti-BPDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals显示文摘 | Pavanello S Bollati V Pesatori AC Kapka L Bolognesi C Bertazzi PA | 2009 | Int J Cancer2009，125，7： | 1 |
| 13 | Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action显示文摘 | Miglio G Rosa AC Rattazzi L | 2012 | Br J Pharmacol2012，167，3： | 1 |
| 14 | Animal Models of Limbic Epilepsies: What Can They Tell Us?显示文摘 | Douglas AC Dan CM Wolfgang L | 2002 | Brain Pathology2002，12，2： | 1 |
| 15 | Effects of constraint-induced movement therapy in adolescents with hemiplegic cerebral palsy : a day camp model显示文摘 | Bonnier B Eliasson AC Krumlinde-Sundholm L | 2006 | Scand J Occup Ther2006，13，1： | 1 |
| 16 | New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo显示文摘 | Shapiro L | 2004 | J Control Release2004，95，2： | 1 |
| 17 | Recognition of double-stranged RNA and activation of NF-kappaB by T oll like receptor 3显示文摘 | Holt AC Medzhitov R | 2001 | Nature2001，413，： | 1 |
| 18 | Prognostic factors in patients with Htirthle cell neoplasms of the thyroid 显示文摘 | Lopez-Penabad L Chiu AC Hoff AO | 2003 | Cancer2003，97，5： | 1 |
| 19 | Elevation of IgA in IgAnephropathy is localized in the serum and not saliva and is restrictedto the IgA1 subclass显示文摘 | Layward L Allen AC Hattersley JM | 1993 | Nephrol Dial Transplant1993，8，1： | 1 |
| 20 | My- cobacterial heat shock protein 70 induces interleu- kin-10 production: immunomodulation of synovial cell cytokine profile and dendritic cell maturation 显示文摘 | Detanico T Rodrigues L Sabritto AC | 2004 | ClinExp Immunol2004，135，2： | 1 |
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