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| 1 | 螺内酯对腹膜透析患者的长期效应显示文摘经血液透析或腹膜透析治疗的终末期肾脏病(end—stagerenalfailure,ESRD)患者,常常合并左心室肥厚(1eftventficularhypertrophy,LVH)、纤维化和毛细血管减少。导致CKD(chronickidneydisease,CKD)患者发生心肌病和左心室衰竭的主要机制有三个:压力超负荷、容量超负荷、以及CKD相关的非血液动力学因素。LVH的晚期事件包括泵衰竭和心律失常性猝死。因此,需要一种新的治疗模式来预防和逆转ESRD患者的LVH和心肌纤维化。据报道,盐皮质激素受体拮抗剂能够改善慢性心力衰竭和心肌梗塞后心力衰竭患者的生存期,并能减少左心室的质量。然而,有关盐皮质激素受体阻断剂对透析患者的作用报道很少,样本也小,尚不足以得出相关结论。 | Ito Y Mizuno M Suzuki Y 王建中 | 2014 | 中华肾病研究电子杂志2014，3，3： | 8 |
| 2 | Preparation of Laminin-apatite-polymer Composites Using Metastable Calcium Phosphate Solutions显示文摘A synthetic polymer with a laminin-apatite composite layer on its surface would be useful as a percutaneous device. The preparation of such a composite was attempted in the present study using poly(ethylene terephthalate) (PET) and polyethylene (PE) as the synthetic polymer. PET and PE plates and those pretreated with an oxygen plasma were alternately dipped in calcium and phosphate ion solutions, and then immersed in a metastable calcium phosphate solution supplemented with laminin (LCP solution). The PET and PE plates pretreated with an oxygen plasma formed a uniform and continuous layer of a laminin-apatite composite on their surfaces. In contrast, the PET and PE plates that had not been pretreated with an oxygen plasma did not form a continuous layer of a laminin-apatite composite on their surfaces. The hydrophilic functional groups on the PET and PE surfaces introduced by the plasma treatment were responsible for the successful laminin-apatite composite coating. | A Oyane M Kasahara N Ichinose Y Yokoyama M Uchida A Ito | 2005 | Journal of Wuhan University of Technology(Materials Science)2005，20，B12： | 3 |
| 3 | Expressionof monocyte chemoattractant protein-1 by nonenzymatically glycated albumin (Amadori adducts) in vascular smooth muscle cells显示文摘 | Ichiki T Funakoshi Y Ito K | 2000 | Bioche Biophys Res Commun2000，269，： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Development of thermal spraying-sintering Technology for solid oxide fuel cells 显示文摘 | OKUMURA K AIHARA Y ITO S | 2000 | Journal of Thermal Spray Technology2000，9，： | 2 |
| 7 | ANCA相关血管炎(AAV)导致双侧脑梗死和继发性脑内出血而无肾功能和呼吸功能障碍显示文摘A 56- year-old man complained of headache and the analgesia of the four extremities. Laboratory data presented signs of inflammation, but no other abnormality such as renal or respiratory dysfunction. Two months after the appearance of the primary symptoms, he developed cerebral infarction of the bilateral corona radiata. The patient did not have any of the risk factors for cerebrovascular disease. He was diagnosed with anti-neutrophil cytoplasmic autoantibody (ANCA)associated vasculitis (AAV) because the systemic examinations revealed only that he tested positive for anti-neutrophil cytoplasmic autoantibody (ANCA). Moreover, the biopsy of the sural nerve displayed microscopic polyangitis (MPA). Despite undergoing steroid pulse therapy, the patient died from the fatal cerebral hemorrhage. The clinical course of AAV is rapid progressive. In cases of atypical cerebrovascular disease, the possibility of ANCA should be investigated. | Ito Y Suzuki K Yamazaki T 蔡同建 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，5： | 2 |
| 8 | Cloning of adiponectin receptors that mediate antidiabetic metabolic effects 显示文摘 | Yamauchi T Kamon J Ito Y et ol | 2003 | Nature2003，423，6941： | 1 |
| 9 | Feasibility of mieroneedles for percutaneous absorption of insulin显示文摘 | Ito Y Hagiwara E Saeki A | 2006 | European journal of pharmaceutical sciences2006，29，1： | 1 |
| 10 | Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method显示文摘 | HIRANO T ITO Y KOBA S | 2004 | Artefioscler Thromb Vasc Biol2004，24，3： | 1 |
| 11 | Antioxidative effects of lactic acid bacteria on the colonic mucosa of iron-overloaded mice 显示文摘 | Ito M Ohishi K Yoshida Y | 2003 | J Agric Food Chem2003，51，15： | 1 |
| 12 | Renal outcome and predictors of clinical renal involvement in patients with silent lupus nephritis 显示文摘 | Wada Y Ito S Ueno M | 2004 | Nephron Clin Pract2004，98，： | 1 |
| 13 | Anti-tumor effect of genetically engineered mesenehy real stem cells in a rat gliomas显示文摘 | Nakarnura K Ito Y Kawano Y | 2004 | C-ene Therapy2004，11，14： | 1 |
| 14 | VEGF121 promotes lymphangiogenesis in the sentinel lymph nodes of nonsmall cell lung carcinoma patients显示文摘 | Kawai H Minamiya Y Ito M | 2008 | Lung Cancer2008，59，1： | 1 |
| 15 | Em18 and Em16, new serologic marker epitopes for alveolar echinococcosis in western blot analysis, are the only two epitopes recognized by commercially available weak positive (cut off)sera for Em2plus-ELISA显示文摘 | Osawa Y Nakao M | 1995 | J Helminth1995，69，4： | 1 |
| 16 | Trajectory-dependent Charge State and Energy Loss of Relativistic Heavy Ions Channeled in a Silicon Surface Barrier Detector 显示文摘 | Ito T Takabayashi Y | | Nucl Instr and Meth B0，，： | 1 |
| 17 | Quantitative detection of disseminated free cancer cells in peritoneal washes with real-time reverse transcriptase-polymerase chain reaction:a sensitive predictor of outcome for patients with gastric carcinoma显示文摘 | Nakanishi H Ito S | 2002 | Ann Surg2002，235，4： | 1 |
| 18 | On the decomposition of a matrix into the sum of stable matrices显示文摘 | Hattori S Maeda H | 1999 | Linear Algebra Appl1999，，297： | 1 |
| 19 | Epodermal growth factor stimulates the recovery of glucose absorption after small bowel transplantation显示文摘 | Hamada Y Ito S | 1998 | J Surg Res1998，80，2： | 1 |
| 20 | The mitochondrial genome of the tapeworm Taenia solium:a finding of the abbreviated stop codon U显示文摘 | Nakao M Sako Y Ito A | 2003 | J Parasitol2003，89，3： | 1 |
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