|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization显示文摘 | Gao W Soloff AC Lu X | | 0，，4： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Imoroved outcome with fluid rest fiction in treatment of uncontrolled hemorrhagic shock 显示文摘 | Capone AC Safar P Stezol ski W | 1995 | J Am Coll Surg1995，180，1： | 1 |
| 6 | Defining regulatory elements in the human KAI1/CD82 metastasis suppressor gene显示文摘 | GAO AC LOU W DONG JT | 2003 | Prostate2003，57，4： | 1 |
| 7 | Patient satisfaction after closed reduction of nasal fractures 显示文摘 | Hung T Chang W Vlanfis AC | 2007 | Arch Facial Hast Surg2007，9，1： | 1 |
| 8 | Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock 显示文摘 | Capone AC Safar P Stezoski W | 2005 | JAmCollSurg2005，180，1： | 1 |
| 9 | Angiotensin Ⅱ up-regulates angiotensin I -conver-ting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway 显示文摘 | Koka V Huang XR Chung AC Wang W Truong LD Lan HY | 2008 | Am J Pathol2008，172，5： | 1 |
| 10 | Efficacy of biological therapies in inflammatory bowel disease:systematic review and meta-analysis显示文摘 | Ford AC Sandborn W J Khan KJ | 2011 | Am J Gastroenterol2011，106，65： | 1 |
| 11 | Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates tobody composition, muscular functional capacity, and peripheral blood flow显示文摘 | Doehner W Bunck AC Rauchhaus M | 2007 | Eur Heart J2007，28，7： | 1 |
| 12 | Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotie neurons显示文摘 | SCALLET AC SCHMUED LC SLIKKER W | 2004 | Toxicol Sci2004，81，2： | 1 |
| 13 | Smad7 suppresses renal fibrosis via altering expression of TGF - beta/Smad3 - regulated microRNAs 显示文摘 | Chung AC Dong Y Yang W | 2013 | Molecular Therapy2013，21，2： | 1 |
| 14 | Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine 显示文摘 | Bowe W Patel NB Logan AC | 2014 | Benef Microbes2014，5，2： | 1 |
| 15 | Fetal interventions for cardiac defects显示文摘 | Tworetzky W Marshll AC | 2004 | Pediatr Clin North Am2004，51，6： | 1 |
| 16 | Proteomics based prediction of antigenicity ofiberiotoxin from eastem Indian scorpion显示文摘 | Gomase VS Phadnis AC Somnath W | 2009 | Internation- al Journal of Drug Discovery2009，1，1： | 1 |
| 17 | The eIF2a/ATF4 pathway is essential for stress-induced autophagy gene expression显示文摘 | B'chir W Maurin AC Carraro V | 2013 | Nuc/e- ic Acids Res2013，41，16： | 1 |
| 18 | The new topical steroid ciclesonide is effective in treatment of allergic rhinitis显示文摘 | Schmidt BM Timmer W Georgens AC | 1999 | J Clin Pharmacol1999，39，： | 1 |
| 19 | Apolipoprotein A-V:a novel apolipoprotein associated with an early phase of liver regeneration显示文摘 | Van der Vliet HN Sammelsm MG Leegwater AC Levels JH Reitsma PH Boers W | 2001 | J Biol Chem2001，276，44： | 1 |
| 20 | Higher risk of adjacent segment degeneration after floating fusions:long-term outcome after low lumbar spine fusions显示文摘 | Disch AC Schmoelz W Matziolis G | 2008 | J Spinal Disord Tech2008，21，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员