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| 1 | A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers显示文摘Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. | Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，46： | 14 |
| 2 | En-dothermic energy transfer:A mechanism for genera-ting very efficient high-energy phosphorescent emis-sion in organic materials显示文摘 | ADACHI C KWONG R C DJUROVICH P | 2001 | Appl Phys Lett2001，79，： | 1 |
| 3 | Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production,while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus显示文摘 | Chinnawirotpisan P Theeragool G Limtong S Toyama H Adachi O Matsushita K | | 0，，： | 1 |
| 4 | Oxidative nanopatterning of titanium surfaces promotes production and extracellular accumulation of osteopontin显示文摘 | Bueno Rde B Adachi P Castro-Raucci LM | 2011 | Braz Dent J2011，22，3： | 1 |
| 5 | Meta-analysis of risedronate for the treatment of postmenopausal osteoporosis 显示文摘 | Cranney A Tugwell P Adachi J | 2002 | Endocr Rev2002，23，4： | 1 |
| 6 | Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk显示文摘 | Chen P Krege JH Adachi JD | 2009 | J Bone Miner Res2009，24，3： | 1 |
| 7 | Tolerability of risedr- onate in postmenopausal women intolerant of alendronate显示文摘 | Adachi J D Adami S Miller P D | 2001 | Agings2001，13，5： | 1 |
| 8 | New quinoproteins in oxidative fermentation显示文摘 | Adachi O Moonmangmee P Shinagawa E | | 0，，01： | 1 |
| 9 | New developments in oxidative fermentation显示文摘 | Adachi O Moonmangmee P Toyama H | | 0，，06： | 1 |
| 10 | 显示文摘 | Adachi Y Su D Muralt P | 2005 | Appl Phys Lett2005，86，17： | 1 |
| 11 | Transient and hosphorylation and nuclear growth control显示文摘 | Adachi T Kar S sustained ERK p translocation in Wang M | 2002 | Coll Physiol2002，192，： | 1 |
| 12 | Efficacy and safety of a once - yearly i v Infusion of zoledronic acid 5 mg versus a once - weekly 70 -mg oral alendronate in the treatment of male osteoporosis: a randomized, multicenter, double- blind, active controlled study显示文摘 | Orwoll E S Miller P D Adachi J D | 2010 | J Bone Miner Res2010，25，10： | 1 |
| 13 | Critical role of cyclinD1 nuclear import in cardiomyocyte proliferation显示文摘 | Tamamori- Adachi M Ito H Sumerejkanchanakij P | 2003 | Circ Res2003，92，1： | 1 |
| 14 | Vascular endo thelial growth factor promoter-based conditionally replicative ad enoviruses for pan-carcinoma application 显示文摘 | Takayama K Reynolds P N Adachi Y | 2007 | Cancer Gene Ther2007，14，1： | 1 |
| 15 | Infection behavior of Venturia nashicola, the cause of scab on Asian Pears 显示文摘 | Park P Ishii H Adachi Y | 2000 | Plant Pathology2000，90，： | 1 |
| 16 | Eficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis:Four-year results from a randomized clinical trial显示文摘 | Delmas P D Ensrud K E Adachi J D | 2002 | Clin Endocrinol Metab2002，87，： | 1 |
| 17 | 显示文摘 | Adachi C Kwong R C Djurovich P | 2001 | Appl Phys Lett2001，79，： | 1 |
| 18 | Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis:four-year results from a randomized clinical trial显示文摘 | Delmas P D Ensrud K E Adachi J D | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
| 19 | Infection Behavior of Venturia nashicola, the Cause of Scab on Asian Pears显示文摘 | Park P Ishii H Adachi Y | 2000 | Phyto patholog2000，90，11： | 1 |
| 20 | Critical role of lipopolysaccharide binding protein and CD14 in immune responses against gram-negative bacterial显示文摘 | Le RD Di P Adachi Y | 2001 | Immunol2001，167，5： | 1 |
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