6篇
您的检索式：作者名="Adam Drake"
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| 1 | Engineering humanized mice for improved hematopoietic reconstitution显示文摘人性化的老鼠是与在整个老鼠的生活产生人的血房间的各种各样的系的人的造血的干细胞嫁接的 immunodeficient 动物。这篇文章在人性化的老鼠的产生考察最近的进展,集中于实际考虑。我们讨论不同 immunodeficient 接受者老鼠紧张,人的造血的干细胞的来源,在扩大的进展和调制接受者老鼠的 cytokine 环境的造血的干细胞,和技术的基因修正的特征,以便提高特定的人的血系房间的宪法。我们加亮新技术创造的机会并且讨论怎么为特定的研究应用程序做基本模型的拓宽的数组的最好的使用上的实际考虑。 | Adam C Drake Qingfeng Chen lianzhu Chen | 2012 | Cellular & Molecular Immunology2012，9，3： | 2 |
| 2 | Of mice and men: what rodent models don't tell us显示文摘 | Adam C Drake | 2013 | Cellular & Molecular Immunology2013，10，4： | 2 |
| 3 | Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent显示文摘How tumor-infiltrating lymphocytes(TILs)that are tumor-specific but functionally tolerant persist in the antigen-expressing tumor tissue is largely unknown.We have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate(TRAMP)model where prostate cancer cells express the T-cell epitope SIYRYYGL(SIY)recognized by CD8 T cells expressing the 2C T-cell receptor(TCR)(referred to as TRP-SIY mice).In TRP-SIY mice,activated 2C T cells rapidly become tolerant following infiltration into the prostate tumor.In this study,we show that tolerant 2C T cells persist in the prostate tumor of TRP-SIY mice by proliferating slowly in a tumor-dependent,but antigen-,interleukin(IL)-7-and IL-15-independent manner.We also show that disappearance of 2C T cells from the lymphoid organs of TRP-SIY mice are due to antigen-induced T-cell contraction rather than altered trafficking or generalized T-cell depletion in the mice.Finally,we show that clonal T cells unreactive to SIY are equally capable of persisting in the prostate tumor.These findings suggest that while functional tolerance of TILs is induced by antigen,persistence of tolerant TILs in the tumor tissue is mediated by a novel mechanism:slow proliferation independent of antigen and homeostatic cytokines.These results also allow CD8 T-cell survival in the tumor environment to be compared with T-cell survival in chronic infection. | Mobolaji O Olurinde Ching-Hung Shen Adam Drake Ailin Bai Jianzhu Chen | 2011 | Cellular & Molecular Immunology2011，8，5： | 1 |
| 4 | Improving the nutritional value of Golden Rice through increased pro-vitamin A content显示文摘 | Paine J A Shipton C A Chaggar S Howells R M Kennedy M J Vernon G Wright S Y Hinchliffe E Adams J L Silverstone A L Drake R | 2005 | Nature Biotechnology2005，23，4： | 1 |
| 5 | Energetic, low- melting salts of simple heterocycles 显示文摘 | Gregory Drake Tommy Hawkins Adam Brand | 2003 | Propellants Explosived Pyrotechnics2003，28，4： | 1 |
| 6 | Improving the nutritional value of Golden Rice through increased pro-vitamin A content 显示文摘 | Paine J A Shipton C A Chaggar S Howells R M Kennedy M J Vernon G Wright S Y Hinchliffe E Adams J L Silverstone A L Drake R | 2005 | Nature Biotechnology2005，23，4： | 1 |
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