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| 1 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 2 | Diabetes therapy and cancer risk:causal effects and other plausible explanations显示文摘 | Hemndez-Daz S Adami HO | 2010 | Diabeto-logia2010，53，5： | 1 |
| 3 | The enigmatic epidemiology of naso- pharyngeal carcinoma显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 4 | Social and economic effects of non-ulcer dyspepsia 显示文摘 | Nyr6n O Adami HO Gustavsson S et aI | 1985 | Scand J Gastroenterol Suppl1985，109，： | 1 |
| 5 | Infections as a maior preventable cause of human cancer显示文摘 | Kuper H Adami HO Trichopoulos D | 2000 | J Intern Med2000，48，17： | 1 |
| 6 | The enigmatic epidemiology of nasopharyngeal carcinoma显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 7 | The enigmatic epidemiology of nasopharyn-geal carcinoma显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 8 | Infections as a major preventable cause of human cancer显示文摘 | Kuper H Adami HO Trichopoulos D | 2000 | J Intern Med2000，248，3： | 1 |
| 9 | Low-potency oestrogen and risk of endometrial cancer: a case-control study显示文摘 | Weiderpass E Baron JA Adami HO | 1999 | Lancet1999，353，29： | 1 |
| 10 | Characteristics of familial breast cancer in Sweden:absence of relation to age and unilateral versus bilateral disease显示文摘 | Adami HO Hansen J Jung B | 1981 | Cancer1981，48，7： | 1 |
| 11 | Risk of endometrial cancer following estrogen replacement with and without progestins 显示文摘 | Weiderpass E Adami HO Baron JA | 1999 | JNatl Cancer Inst1999，91，13： | 1 |
| 12 | Prospeclive study of body size and risk for stroke amongst women below age 60显示文摘 | Lu M Ye W Adami HO | 2006 | J Intern Med2006，260，5： | 1 |
| 13 | The enigmatic epidemiology of nasopharyngeal carcinoma 显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 14 | The non-Hodgkin lym- phomas: a review of the pidemiologic literature显示文摘 | Alexander DD Mink l-'J Adami HO | 2007 | lnt J Cancer2007，120，12： | 1 |
| 15 | The relation between survival and age at diagnosis and breast cancer显示文摘 | Adami HO Malker B Holmberg L | 1986 | N Engl J Med1986，315，9： | 1 |
| 16 | The enigmatic epidemiology of nasopha ryngeal carcinoma显示文摘 | Chang ET Adami HO | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 17 | Prospective study of body size and risk for stroke amongst women below age 60 显示文摘 | Lu M Ye W Adami HO | 2006 | J Intern Med2006，260，5： | 1 |
| 18 | Prospective study of body size and risk for stroke amongst women below age60显示文摘 | Lu M Ye W Adami Ho | 2006 | J Intern Med2006，260，5： | 1 |
| 19 | Paraquat and Parkinson's dis- ease: an overview of the epidemiology and a review of two re- cent studies 显示文摘 | Mandel JS Adami HO Cole P | 2012 | Regul Toxicol Pharmacol2012，62，： | 1 |
| 20 | Interaction between single nucleotide polyrnorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk 显示文摘 | Cooper ML Adami HO Grtonberg H | 2008 | Cancer Res2008，68，10： | 1 |
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