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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Distribution of cardiac stem cel s in the human heart显示文摘 | Arsalan M Woitek F Adams V | | 0，，： | 1 |
| 3 | The Bifactor Model of the Maslach Burnout Inventory–Human Services Survey(MBI‐HSS)-An Alternative Measurement Model of Burnout显示文摘 | Meszaros V Adam S Szabo M | 2014 | Stress and Health2014，30，1： | 1 |
| 4 | Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes:results of 3 randomized studies显示文摘 | Sandri M Adams V Gielen S | 2005 | Circulation2005，111，： | 1 |
| 5 | Reduction of train-induced building vibrations by using open and filled trenches显示文摘 | Adam M Estorff O V | 2005 | Computers and Structures2005，83，： | 1 |
| 6 | Lack of antioxidant activity of the antiatherogenic compound L-arginine 显示文摘 | ADAMS M R CO V P ROLAND S | 1999 | Atherosclerosis1999，146，2： | 1 |
| 7 | Serum and tissue zinc in epithelial malignancies: a meta-analysis显示文摘 | Gumulec J Masarik M Adam V | 2014 | PLoS One2014，9，99： | 1 |
| 8 | Proof of concept processes in UK university technology transfer:an absorptive capacity perspective显示文摘 | Mc Adam R Mc Adam M Brown V | 2009 | R&D Management2009，39，2： | 1 |
| 9 | Analysis of semiconductor laser optical amplifiers 显示文摘 | Adams M J Collins J V Henning I D | 1985 | IEE Proceedings1985，132，1： | 1 |
| 10 | Low-dose thalidomide regimens in therapy of relapsed or refractory multiple myeloma 显示文摘 | Zemanova M Seudla V Adam Z | 2008 | Neoplasma2008，55，4： | 1 |
| 11 | Mycosubtilin overproduction by Bacillus subtilis BBG100 enhances the organism's antagonistic and biocontrol activities 显示文摘 | LECLERE V BECHET M ADAM A | 2005 | Appl and Enviro Micronbiol2005，71，8： | 1 |
| 12 | Mycosubtilin overproduction by Bacillus subtilis BBG100 enhances the organism's antagonistic and biocontrol activities显示文摘 | Leclère V Béchet M Adam A | 2005 | Applied and Environmental Microbiology2005，71，8： | 1 |
| 13 | An architecture for large - scale Intemet measurement 显示文摘 | V Paxson J Mahdavi A Adams M Mathis | 1998 | IEEE Communications1998，36，8： | 1 |
| 14 | Vitamin d-directed rheostatic regulation of monocyte antibacterial responses显示文摘 | Adams JS Ren S Liu PT Chun RF Lagishetty V Gombart AF Borregaard N Modlin RL Hewison M | | 0，，： | 1 |
| 15 | Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor cells in Patients with Ischemic Syndromes:Results of 3 Randomized Studies显示文摘 | Sandri M Adams V Gielen S | | 0，，： | 1 |
| 16 | Equine infectious anemia virus(EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection 显示文摘 | Rwambo P M Issel C J Adams W V | 1990 | Arch Virel1990，111，： | 1 |
| 17 | Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes:results of 3 randomized studies显示文摘 | Sandri M Adams V Gielen S | 2005 | Circulation2005，111，25： | 1 |
| 18 | Reduction of train-induced building vibrations by using open and tilled trenches显示文摘 | Adam M Estorff O V | 2005 | Computers and Structures2005，83，： | 1 |
| 19 | The potential impact of helminth infection ontrials of novel tuberculosis vaccines显示文摘 | Hatherill M Adams V Hughes J | 2009 | Vaccine2009，27，35： | 1 |
| 20 | Mammalian metallothioneins:Properties and functions显示文摘 | Babula P Masarik M Adam V | 2012 | Metallomics2012，4，： | 1 |
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