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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | Clinical outcomes of ERCP-related retroperitoneal perforations显示文摘Endoscopic retrograde cholangiopancreatography(ERCP)-related perforations represent rare but often severe conditions. While lesions with intraperitoneal perforation have an almost imperative indication to surgery, whether or not to manage retroperitoneal perforations surgically is still an area of debate. The aim of the present work was to review the available clinical evidence on the operatively and medi cally treated ERCP-related retroperitoneal perforations. From MEDLINE/Pub Med databases 137 patients with retroperito neal perforation were included from 12 studies that met the selection criteria for data investigation and analysis. Twenty four patients were treated by prompt surgery; 113 were primarily managed conservatively and about 20% of these patients required surgery subsequently. Overall, the morbid ity and mortality were 15.4% and 6.6%, respectively. Although most patients with retroperitoneal perforation may benefit from a non-operative management, a considerable number of patients fail to respond to medical treatment and require sur gery afterwards. Identifying those patients who are at highest risk of poor outcome after conservative treatment should be considered a research priority. | Francesco Guerra Giuseppe Giuliani Diego Coletta Stefano Amore Bonapasta Giovanni Battista Levi Sandri | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 7 |
| 3 | Diverticular disease of the colon:New perspectives in symptom development and treatment显示文摘Diverticular disease of the colon is a common disease worldwide. Although the disease is asymptomatic in about 70-80 % of patients, it represents, at least in Western countries, one of the most important gastrointestinal diseases in terms of direct and indirect health costs. Pathocenesis of the disease is still unknown. However, it is the result of complex interactions between colonic structure, intestinal motility, diet and genetic factors. Whilst efficacious preventive strategies remain to be identified, fibre supplementation in the diet is recommended. Why symptoms develop is still unclear. Results of recent experimental studies on irritable bowel syndrome speculated that low grade inflammation of colonic mucosa, induced by changes in bacterial microflora,could affect the enteric nervous system, which is crucial for normal gut function, thus favouring symptom development.This hypothesis could be extrapolated also for diverticular disease, since bacterial overgrowth is present, at least in a subgroup of patients. These perspectives on symptom development are reviewed and new therapeutic approaches are hypothesized. | Antonio Colecchia Lorenza Sandri Simona Caoodicasa Amanda Vestito Giuseppe Mazzella Tommaso Staniscia Enrico Roda Davide Festi | 2003 | World Journal of Gastroenterology2003，9，7： | 7 |
| 4 | Laparoscopic left liver lobectomy for hepatocellular carcinoma in a cirrhotic patient: a video report显示文摘We present a video case of a 51-year-old man admitted to our surgical and liver transplantation unit for hepatocellular cancer(HCC). Patient has a HCV cirrhosis with portal hypertension and esophageal varices F1. Child Pugh score was B7 and model of end staged liver disease(MELD) was 11. Body mass index(BMI) was 26.7 and ASA score was 2. No previous abdominal surgery. According with our multidisciplinary group we suggest a laparoscopic left lobectomy for the patient. Pringle manoeuvre was not performed. Operation time was 193 min and blood loss estimation was 100 cc. No transfusion was required. Postoperative course was uneventful, grade I of Clavien-Dindo Classification. Patient was discharged in day 8. In our experience laparoscopic resection in cirrhotic liver should be performed in selected patients and in an experienced team. | Giovanni Battista Levi Sandri Giovanni Vennarecci Roberto Santoro Pasquale Lepiane Marco Colasanti Giuseppe Maria Ettorre | 2014 | Chinese Journal of Cancer Research2014，26，6： | 6 |
| 5 | Impact of the gut microbiota on rodent models of human disease显示文摘Traditionally bacteria have been considered as either pathogens,commensals or symbionts.The mammal gut harbors 1014 organisms dispersed on approximately1000 different species.Today,diagnostics,in contrast to previous cultivation techniques,allow the identification of close to 100%of bacterial species.This has revealed that a range of animal models within different research areas,such as diabetes,obesity,cancer,allergy,behavior and colitis,are affected by their gut microbiota.Correlation studies may for some diseases show correlation between gut microbiota composition and disease parameters higher than 70%.Some disease phenotypes may be transferred when recolonizing germ free mice.The mechanistic aspects are not clear,but some examples on how gut bacteria stimulate receptors,metabolism,and immune responses are discussed.A more deeper understanding of the impact of microbiota has its origin in the overall composition of the microbiota and in some newly recognized species,such as Akkermansia muciniphila,Segmented filamentous bacteria and Faecalibacterium prausnitzii,which seem to have an impact on more or less severe disease in specific models.Thus,the impact of the microbiota on animal models is of a magnitude that cannot be ignored in future research.Therefore,either models with specific microbiota must be developed,or the microbiota must be characterized in individual studies and incorporated into data evaluation. | Axel Kornerup Hansen Camilla Hartmann Friis Hansen Lukasz Krych Dennis Sandris Nielsen | 2014 | World Journal of Gastroenterology2014，20，47： | 4 |
| 6 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 7 | Design and criteria of electrospun fibrous scaffolds for the treatment of spinal cord injury显示文摘The complex pathophysiology of spinal cord injury may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. Many efforts have been performed to design and develop suitable scaffolds for spinal cord regeneration, keeping in mind that the reconstruction of a pro-regenerative environment is the key challenge for an effective neurogenesis. The aim of this review is to outline the main features of an ideal scaffold, based on biomaterials, produced by the electrospinning technique and intended for the spinal cord regeneration. An overview of the polymers more investigated in the production of neural fibrous scaffolds is also provided. | Barbara Vigani Silvia Rossi Giuseppina Sandri Maria Cristina Bonferoni Franca Ferrari | 2017 | Neural Regeneration Research2017，12，11： | 4 |
| 8 | Surgical Resection Versus Local Ablation for HCC on Cirrhosis: Results from a Propensity Case-Matched Study显示文摘 | Andrea Ruzzenente Alfredo Guglielmi Marco Sandri Tommaso Campagnaro Alessandro Valdegamberi Simone Conci Fabio Bagante Gianni Turcato Mirko D’Onofrio Calogero Iacono | 2012 | Journal of Gastrointestinal Surgery2012，，2： | 3 |
| 9 | Laparoscopic approach for hepatocellular carcinoma: where is the limit?显示文摘Hepatocellular cancer(HCC)is the sixth most common malignant tumor worldwide and the most common primary liver cancer(1).Liver resection or liver transplantation is the therapeutic gold standards in patient with HCC. | Giuseppe Maria Ettorre Giovanni Battista Levi Sandri | 2014 | Chinese Journal of Cancer Research2014，26，3： | 3 |
| 10 | Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable显示文摘Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not usable.Methods:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to HA.Results:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were analyzed.Four groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as conduit.The median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,P<0.001).The occurrence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically different.Level of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA group.No difference was observed regarding graft(P=0.18)and patient(P=0.16)survival.Conclusions:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta. | Jean Marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux Aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier Michel Rayar | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 11 | The ALPPS procedure for hepatocellular carcinoma显示文摘 | G. Vennarecci A. Laurenzi G.B. Levi Sandri E. Busi Rizzi M. Cristofaro M. Montalbano P. Piselli A. Andreoli G. D’Offizi G.M. Ettorre | 2014 | European Journal of Surgical Oncology2014，，： | 3 |
| 12 | 腹腔镜下左肝叶切除术:1例肝细胞癌合并肝硬化患者的视频报道显示文摘视频中的患者是1名51岁因肝细胞癌收治于外科和肝移植病房的患者。该患者合并HCV感染引起的肝硬化并门静脉高压形成及食管曲张形态为F1。Child-Pugh评分为B级7分,终末期肝病模型评分为11分,BMI指数为26.7,ASA评分为2分。既往无腹部手术史。多学科诊疗团队意见是为患者实施腹腔镜下左肝叶切除术。术中未采用Pringle法行肝门阻断。手术时间为193 min,失血量约为100 mL,术中无输血。患者术后恢复平稳,Clavien-Dindo分级为1级,并于术后第8天出院。笔者的经验是有经验的手术团队可以在需要手术的肝硬化患者中适当地实施腹腔镜手术。 | Giovanni Battista Levi Sandri Giovanni Vennarecci Roberto Santoro Pasquale Lepiane Marco Colasanti Giuseppe Maria Ettorre | 2015 | 中国普通外科杂志2015，24，1： | 2 |
| 13 | Cystic fibrosis transmembrane conductance regulator functional evaluations in a G542X+/-IVS8Tn:T7/9 patient with acute recurrent pancreatitis显示文摘BACKGROUND Acute recurrent pancreatitis(ARP)is characterized by episodes of acute pancreatitis in an otherwise normal gland.When no cause of ARP is identifiable,the diagnosis of'idiopathic'ARP is given.Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR)gene increase the risk of ARP by 3-to 4-times compared to the general population,while cystic fibrosis(CF)patients present with a 40-to 80-times higher risk of developing pancreatitis.CASE SUMMARY In non-classical CF or CFTR-related disorders,CFTR functional tests can help to ensure a proper diagnosis.We applied an individualized combination of standardized and new CFTR functional bioassays for a patient referred to the Verona CF Center for evaluation after several episodes of acute pancreatitis.The CFTR genotype was G542X+/-with IVS8Tn:T7/9 polymorphism.The sweat(Cl-)values were borderline.Intestinal current measurements were performed according to the European Cystic Fibrosis Society Standardized Operating Procedure.Recent nasal surgery for deviated septum did not allow for nasal potential difference measurements.Lung function and sputum cultures were normal;azoospermia was excluded.Pancreas divisum was excluded by imaging but hypoplasia of the left hepatic lobe was detected.Innovative tests applied in this case include sweat rate measurement by image analysis,CFTR function in monocytes evaluated using a membrane potential-sensitive fluorescent probe,and the intestinal organoids forskolin-induced swelling assay.CONCLUSION Combination of innovative CFTR functional assays might support a controversial diagnosis when CFTR-related disorders and/or non-classical CF are suspected. | Sara Caldrer Gabriella Bergamini Angela Sandri Silvia Vercellone Luca Rodella Angelo Cerofolini Francesco Tomba Filippo Catalano Luca Frulloni Mario Buffelli Gloria Tridello Hugo de Jonge Baroukh Maurice Assael Claudio Sorio Paola Melotti | 2019 | World Journal of Clinical Cases2019，7，22： | 2 |
| 14 | Low-dose Oral Methotrexateand Cyelophosphamide in Metastatic Breast Cancer: Antitumor Activity and Correlation with Vascular Endothelial Growth Factor Levels显示文摘 | Colleoni M Rocca A Sandri M T | 2002 | Ann Oncol2002，13，1： | 1 |
| 15 | Signalling pathways regula- ring muscle mass in ageing skeletal muscle : the role of the IGF1-Akt- mTOR-FoxO pathway 显示文摘 | Sandri M Barberi L Bijlsma A Y | 2013 | Biogerontolagy2013，14，3： | 1 |
| 16 | Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK(p38 and ERK1/2)signaling pathways显示文摘 | Sandri S Hatanaka E Franco AG | 2008 | Immunology Letters2008，121，1： | 1 |
| 17 | Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: cor- relation with pathological outcome 显示文摘 | Sandri MT Bottari F Franchi D | 2013 | Gynecol Oncol2013，128，2： | 1 |
| 18 | Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy显示文摘 | Sandri M Sandri C Gilbert A | 2004 | Cell2004，117，3： | 1 |
| 19 | FoxO transcription factors induce the atrophy-related ubiquitin ligase atrogin-I and cause skeletal muscle atrophy 显示文摘 | Sandri M Sandri C Gilbert A | 2004 | Cell2004，117，3： | 1 |
| 20 | Integrin signaling and lung cancer显示文摘 | Caccavari F Valdembri D Sandri C | 2010 | Cell Adhesion & Migration2010，4，1： | 1 |
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