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| 1 | Evaluation of mine scale longwall top coal caving parameters using continuum analysis显示文摘A mine-scale analysis of Longwall Top Coal Caving (LTCC) is performed using a continuum mechanics finite element solver called COSFLOW. The uniqueness of COSFLOW is that it incorporates Cosserat continuum theory in its formulation for describing the load deformation of bedded rocks. It is shown that such a continuum based code is valuable for assessing the feasibility of introducing LTCC in any mine. Various LTCC parameters, for example chock convergences, top coal failure behavior, strata cavingmechanism, abutment stresses and vertical stresses, were evaluated for a mine using COSFLOW. | Manoj Khanal Deepak Adhikary Rao Balusu | 2011 | Mining Science and Technology2011，21，6： | 9 |
| 2 | Numerical analysis and geotechnical assessment of mine scale model显示文摘Various numerical methods are available to model,simulate,analyse and interpret the results;however a major task is to select a reliable and intended tool to perform a realistic assessment of any problem.For a model to be a representative of the realistic mining scenario,a verified tool must be chosen to perform an assessment of mine roof support requirement and address the geotechnical risks associated with longwall mining.The dependable tools provide a safe working environment,increased production,efficient management of resources and reduce environmental impacts of mining.Although various methods,for example,analytical,experimental and empirical are being adopted in mining,in recent days numerical tools are becoming popular due to the advancement in computer hardware and numerical methods.Empirical rules based on past experiences do provide a general guide,however due to the heterogeneous nature of mine geology(i.e.,none of the mine sites are identical),numerical simulations of mine site specific conditions would lend better insights into some underlying issues.The paper highlights the use of a continuum mechanics based tool in coal mining with a mine scale model.The continuum modelling can provide close to accurate stress fields and deformation.The paper describes the use of existing mine data to calibrate and validate the model parameters,which then are used to assess geotechnical issues related with installing a new high capacity longwall mine at the mine site.A variety of parameters,for example,chock convergences,caveability of overlying sandstones,abutment and vertical stresses have been estimated. | Khanal Manoj Adhikary Deepak Balusu Rao | 2012 | International Journal of Mining Science and Technology2012，22，5： | 2 |
| 3 | Geneti- cally modified mouse models for premature ovarian failure(POF) 显示文摘 | Krishna Jagarlamudi Pradeep Reddy Deepak Adhikari | 2010 | Molecular and Cellular Endocrinology2010，315，2： | 1 |
| 4 | Effect of strata properties and panel widths on chock performance显示文摘The selection of optimum chock (support) capacity is very crucial for a successful longwall mining. The selection of chock capacity depends on the site-specific geotechnical parameters, constraints and longwall panel geometry, which are generally not known in detail in priority. Hence, based on the field and laboratory data, various possible combinations should be analyzed to cater for the unforeseeable mining conditions. This paper discusses the use of numerical model for selecting an appropriate chock capacity based on the site-specific geological and geotechnical information and longwall panel geometry. The fracture mechanisms of immediate and main roofs are also discussed for various panel widths and support capacities. For the models considered, the chock convergence is predicted to increase by about 33% due to the increase in face width from 100 to 260 m. Similarly, the massive roof strata are found to yield higher chock convergence compared to bedded strata. | Manoj Khanal Deepak Adhikary Rao Balusu | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，S1： | 1 |
| 5 | Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles 显示文摘 | Deepak Adhikari Kui Liu | 2009 | Endocrine Reviews2009，8，30： | 1 |
| 6 | Inhibitory phosphorylation of Cdkl mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan显示文摘在哺乳动物的女细菌房间开发的一个唯一的特征是他们在成熟分裂的前期的显著地长的拘捕我,它在人持续直到 50 年。休眠、成长的卵母细胞在前期被逮捕我并且完全缺乏能力恢复成熟分裂。这里,我们证明女细菌房间的延长 meiotic 拘捕大部分经由 Cdk1 的禁止的 phosphorylation 被完成(cyclin 依赖的 kinase 1 ) 。在我们介绍了变异的 Cdk1 不能被 phosphorylation (Cdk1AF ) 在小 meiotically 无能的卵母细胞禁止的 T14AY15F ,我逮捕的前期被打断,导致女细菌房间的早熟的损失。我们证明在种卵母细胞, Cdk1AF 与压缩染色体和,卵母细胞死亡在休眠卵母细胞跟随的幼芽的泡故障导致成熟分裂的早熟的恢复, Cdk1AF 直接,并且两个都导致卵母细胞死亡状况损坏维持女繁殖 lifespan 的卵巢的储备,它应该在在老鼠的 1 年附近。而且, Cdk1 的禁止的 phosphorylation 的打断导致 DNA 损坏,它被 Chk2 的正式就职伴随(检查点 kinase 2 )-p53/p63-dependent 房间死亡小径,它最后引起全球卵母细胞死亡。一起,我们的数据证明 Cdk1 活动的调停 phosphorylation 的抑制是在哺乳动物的女细菌房间维持过长的前期拘捕的关键因素之一,它为在女哺乳动物保存细菌房间水池和繁殖 lifespan 是必要的。 | Deepak Adhikari Kiran Busayavalasa Jingjing Zhang Mengwen Hu Sanjiv Risal Mustafa Bilal Bayazit Meenakshi Singh M Kasim Diril Philipp Kaldis Kui Liu | 2016 | Cell Research2016，26，11： | 0 |
| 7 | Numerical Modeling of Porous Flow in Fractured Rock and Its Applications in Geothermal Energy Extraction显示文摘Understanding the characteristics of hydraulic fracture,porous flow and heat transfer in fractured rock is critical for geothermal power generation applications,and numerical simulation can provide a powerful approach for systematically and thoroughly investigating these problems. In this paper,we present a fully coupled solid-fluid code using discrete element method(DEM) and lattice Boltzmann method(LBM). The DEM with bonded particles is used to model the deformation and fracture in solid,while the LBM is used to model the fluid flow. The two methods are two-way coupled,i.e.,the solid part provides a moving boundary condition and transfers momentum to fluid,while the fluid exerts a dragging force to the solid. Two widely used open source codes,the ESy S_Particle and the OpenL B,are integrated into one code and paralleled with Message Passing Interface(MPI) library. Some preliminary 2D simulations,including particles moving in a fluid and hydraulic fracturing induced by injection of fluid into a borehole,are carried out to validate the integrated code. The preliminary results indicate that the new code is capable of reproducing the basic features of hydraulic fracture and thus offers a promising tool for multiscale simulation of porous flow and heat transfer in fractured rock. | Yucang Wang Shimin Wang Sheng Xue Deepak Adhikary | 2015 | Journal of Earth Science2015，26，1： | 0 |
| 8 | Intervention on inhalation technique of rotahaler in patients with chronic obstructive pulmonary disease and asthma显示文摘Inhalation is the preferred route of delivery for drugs intended for both COPD and asthma as drugs are delivered directly to their site of action,leading to a rapid onset of action and a low incidence of side effects.Incorrect technique when taking inhaled medications frequently prevents patients from receiving the maximal benefit from their medications[1].Thus,prospective interventional study was conducted to evaluate the effectiveness of inhalation techniques of Rotahaler in patients with COPD and Asthma[2,3]. | G.M.Khan Paudel Badri Thapa Parbati Duwal Anita Adhikari Atul Paudel Deepak Regmi Dipendra Barakoti Himal Gwachha Kabita Koju Nirmala | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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