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| 1 | Automating regression testing for evolving GUI software显示文摘 | Atif M Adithya N Xie Qing | 2005 | Journal of Software Maintenance and Evolution2005，17，1： | 1 |
| 2 | Proportion of thyroid cancer and other cancers in the democratic republic of Congo显示文摘BACKGROUND Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo(DRC).The proportion of thyroid cancer has increased over the past three decades.There are very few studies on cancer epidemiology,and in particular on thyroid cancer in the DRC.AIM To establish the most recent proportion of thyroid cancer in the DRC compared to other cancers.METHODS This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of Kinshasa.This study included all cancer cases recorded in the registers between 2005 and 2019.RESULTS From a sample of 6106 patients,including all cancer types,68.3%cases were female and 31.7%were male.Breast and cervical cancer were the most common types of cancer in women and,prostate and skin cancer were the most common types in men.Thyroid cancer was sixth in proportion in women and eleventh in men compared to all cancers.Papillary carcinoma was the most common of thyroid cancers.Rare cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7%and 2%,respectively.CONCLUSION Newer diagnostic tools led to a surge in cancer diagnoses in the DRC.Thyroid cancer has more than doubled its proportion over the last several decades in the country. | John Bukasa-Kakamba Ayrton I Bangolo Pascal Bayauli Branly Mbunga Francis Iyese Aliocha Nkodila Ali Atoot Gaurav Anand Stacy H Lee Maimona Chaudhary Pamela Q Fernandes Hari PSS Mannam Adithya Polavarapu Merajunissa Merajunnissa Abdullah Azhar Mohan N Alichetty Gauravdeep Singh Georgemar V Arana Jr Imranjot Sekhon Manbir Singh JoséD Rodriguez-Castro Adam Atoot Simcha Weissman Jean Rene M’buyamba | 2023 | World Journal of Experimental Medicine2023，13，3： | 0 |
| 3 | Post-stroke mRNA expression profile of MMPs:effect of genetic deletion of MMP-12显示文摘background and purpose Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases(MMPs)in rats and the detrimental role of MMP-12 in post-stroke brain damage.We hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other MMPs.We tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout mice.Methods Focal cerebral ischaemia was induced in wildtype and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament suture.One hour after ischaemia,reperfusion was initiated by removing the monofilament.One day after reperfusion,ischaemic brain tissues from various groups of mice were collected,and total RNA was isolated and subjected to cDNA synthesis followed by PCR analysis.results Although the post-stroke expression profile of MMPs in the ischaemic brain of mice is different from rats,there is a clear species similarity in the expression of MMP-12,which was found to be predominantly upregulated in both species.Further,the post-stroke induction or inhibition of various MMPs in MMP-12 knockout mice is different from their respective expression profile in wild-type mice.Moreover,the brain mRNA expression profile of various MMPs in MMP-12 knockout mice under normal conditions is also different to their expression in wild-type mice.Conclusions In the ischaemic brain,MMP-12 upregulates several fold higher than any other MMP.Mice derived with the genetic deletion of MMP-12 are constitutive and have altered MMP expression profile both under normal and ischaemic conditions. | Koteswara Rao Nalamolu Bharath Chelluboina Ian B Magruder Diane N Fru Adithya Mohandass Ishwarya Venkatesh Jeffrey D Klopfenstein David M Pinson Krishna M Boini Krishna Kumar Veeravalli | 2018 | Stroke & Vascular Neurology2018，3，3： | 0 |
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