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| 1 | Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors显示文摘AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver tumors.METHODS:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,Romania.We recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC analysis.The difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver lesion.RESULTS:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive value.The artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive value.The accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase followed by wash-out in the portal and first seconds of the late phases.For the hypovascular metastases did not show significant contrast uptake during the arterial phase,which resulted in negative differences between the maximum intensities.We registered wash-out in the late phase for most of the hypervascular metastases.Liver hemangiomas had contrast uptake in the arterial phase without agent wash-out in the portallate phases.The focal fatty changes did not show any differences from surrounding liver parenchyma,resulting in similar TIC patterns and extracted parameters.CONCLUSION:Neural network analysis of contrastenhanced ultrasonography-obtained TICs seems a promising field of development for future techniques,providing fast and reliable diagnostic aid for the clinician. | Costin Teodor Streba Mihaela Ionescu Dan Ionut Gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 2 | A new Formalism for Failure Diagnosis:Ant Colony Decision Petri Nets显示文摘 | Calin Ciufudean Adrian Graur Constantin Filote | | 0，，01： | 1 |
| 3 | Stability of peakons显示文摘 | Adrian Constantin Waner A Atrauss | | 0，，： | 1 |
| 4 | A CFD study on the effects of operating an engine with low in- take valve lift at idle corresponding speed显示文摘 | Clenci Adrian Constantin Iorga-Siman | 2014 | Energy2014，71，3： | 1 |
| 5 | Deep- Depletion Breakdown Voltage of Silicon - Dioxide/Silicon MOS Capacitors显示文摘 | ADRIAN RUSU CONSTANTIN BULUCEA | 1979 | IEEE Transactions on Electron Devices1979，26，3： | 1 |
| 6 | Transforming growth tactoralpha in human hepatocellular carci-noma and coexpression with hepatitis B surface antigen in adjacentliver显示文摘 | Chu CH Constantine A Adrian M | 1992 | Cancer1992，46，70： | 1 |
| 7 | A new for- malism for failure diagnosis: ant colony decision Petri nets显示文摘 | Calin Ciufudean Adrian Graur Constantin Filote | 2007 | Journal of software2007，2，1： | 1 |
| 8 | A new For- malism for Failure Diagnosis: Ant Colony Decision Petri Nets 显示文摘 | Calin Ciufudean Adrian Graur Constantin Filote etc | 2007 | Journal of software2007，2，1： | 1 |
| 9 | Global Weak Solutions for a Shallow Water Equation显示文摘 | Adrian Constantin Luc Molinet | 2000 | Communications in Mathematical Physics2000，，1： | 1 |
| 10 | Wave breaking for nonlinear nonlocal shallow water equations显示文摘 | Adrian Constantin Joachim Escher | 1998 | Acta Mathematica1998，，2： | 1 |
| 11 | The initial value problem for a generalized Boussinesq equation显示文摘 | Adrian Constantin Luc Molinet | 2002 | Differential and Integral Equations2002，15，9： | 1 |
| 12 | Orbital stability of solitary waves for a shallow water equation显示文摘 | Adrian Constantin Luc Molinet | 2001 | Physic D2001，157，： | 1 |
| 13 | On the Inverse Spectral Problem for the Camassa–Holm Equation显示文摘 | Adrian Constantin | 1998 | Journal of Functional Analysis1998，，2： | 1 |
| 14 | Deep-Depletion Breakdown Voltage of Silicon-Dioxide Sililon Mas Capacitors 显示文摘 | ADRIAN RUSU CONSTANTIN BULUCEA | 1979 | IEEE Transactions on Electron Devices1979，26，3： | 1 |
| 15 | The Initial Value Problem for a Generalized Bossinesq Equation显示文摘 | ADRIAN CONSTANTIN LUC MOLINET | 2000 | Differential and Intergral Equation2000，5，9： | 1 |
| 16 | A CFD (computational uid dynamics) study on the effects ofoperating an engine with low intake valve lift at idle corresponding speed 显示文摘 | Adrian Constantin Clenci Victor Iorga-Siman | 2014 | Energy2014，，71： | 1 |
| 17 | Synthesis, Structure, and Luminescent Properties of Europium-Doped Hydroxyapatite Nanocrystalline Powders显示文摘 | Carmen Steluta Ciobanu Simona Liliana Iconaru Florian Massuyeau Liliana Violeta Constantin Adrian Costescu Daniela Predoi Takuya Tsuzuki | 2012 | Journal of Nanomaterials2012，，： | 1 |
| 18 | On the blow-up rate and the blow-up set of breaking waves for a shallow water equation显示文摘 | Adrian Constantin Joachim Escher | 2000 | Mathematische Zeitschrift2000，，1： | 1 |
| 19 | Wave breaking for nonlinear nonlocal shallow water equations显示文摘 | Adrian Constantin Joachim Escher | 1998 | Acta Mathematica1998，，2： | 1 |
| 20 | Minimally invasive surgery for gastro-oesophageal junction adenocarcinoma: Current evidence and future perspectives显示文摘Minimally invasive surgery is increasingly indicated in the management of malignant disease.Although oesophagectomy is a difficult operation,with a long learning curve,there is actually a shift towards the laparoscopic/thoracoscopic/robotic approach,due to the advantages of visualization,surgeon comfort(robotic surgery)and the possibility of the whole team to see the operation as well as and the operating surgeon.Although currently there are still many controversial topics,about the surgical treatment of patients with gastro-oesophageal junction(GOJ)adenocarcinoma,such as the type of open or minimally invasive surgical approach,the type of oesophago-gastric resection,the type of lymph node dissection and others,the minimally invasive approach has proven to be a way to reduce postoperative complications of resection,especially by decreasing pulmonary complications.The implementation of new technologies allowed the widening of the range of indications for this type of surgical approach.The short-term and long-term results,as well as the benefits for the patient-reduced surgical trauma,quick and easy recovery-offer this type of surgical treatment the premises for future development.This article reviews the updates and perspectives on the minimally invasive approach for GOJ adenocarcinoma. | Rodica Birla Petre Hoara Florin Achim Valeriu Dinca Diana Ciuc Silviu Constantinoiu Adrian Constantin | 2023 | World Journal of Gastrointestinal Oncology2023，15，10： | 0 |
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