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| 1 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 2 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 3 | MW and Mvar management on supply and demand side for meeting voltage stability margin criteria显示文摘 | AFFONSO C M SILVA L C LIMA F G | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 4 | Differences in sensitivity to UVC, UVB and UVA radiation of a multidrug-resistant cell line overexpressing P-glycoprotein显示文摘 | Trindade G S Capella L S Affonso M | 1999 | Photochem Photobiol1999，69，6： | 1 |
| 5 | Comparative analysis between ROCOF and vector surge relays for distfibuted generation applications显示文摘 | Freitas W Xu W Affonso C M | 2005 | IEEE Trans Power Del2005，20，2： | 1 |
| 6 | Comparative analysis between ROCOF and vector surge relays for distributed generation applications显示文摘 | FREITAS W XU W AFFONSO C M | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 7 | MW and MVar Management on Supply and Demand Side for Meeting Voltage Stability Margin Criteria显示文摘 | Carolina M Affonso Luiz C P da Silva Flavio G M Lima | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 8 | MW and Mvar management on supply and demand side for meeting voltage stability margin criteria 显示文摘 | AFFONSO C M SILVA L C LIMA F G | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 9 | Effect of high levels of dietary vitamin C on the blood responses of matrinx ( Brycon amazonicus) 显示文摘 | AFFONSO E G SILVA E C TAVARES-DIAS M | 2007 | Comparative Biochemistry Physiology A2007，147，2： | 1 |
| 10 | Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective Study显示文摘 | Daniela Veit Barreto Fellype de Carvalho Barreto Aluízio Barbosa de Carvalho Lilian Cuppari Sérgio Antonio Draibe Maria Aparecida Dalboni Rosa Maria Affonso Moyses Kátia Rodrigues Neves Vanda Jorgetti Márcio Miname Raul D. Santos Maria Eugênia F. Canziani | 2008 | American Journal of Kidney Diseases2008，，6： | 1 |
| 11 | Performance of ROCOF relays for embedded generation applications显示文摘 | Affonso C M Freitas W Xu W | 2005 | IEEE Proceedings of Generation Transmission and Distribution2005，152，1： | 1 |
| 12 | Comparative Analysis Between ROCOF and Vector Surge Relays for Distribut- ed Generation Applications 显示文摘 | FREITAS W XU W AFFONSO C M HUANG Z | 2005 | IEEE Transactions on Power Del- ivery2005，20，2： | 1 |
| 13 | MW and MVar management on supply and demand side for meeting voltage stability margin criteria 显示文摘 | Affonso C M da Silva L C P Lima F G M | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 14 | Comparative Analysis Between ROCOF and Vector Surge Relays for Distributed Generation Applications 显示文摘 | FREITAS W XU W AFFONSO C M | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 15 | MW and Mvar management on supply and demand side for meeting voltage stability margin criteria显示文摘 | AFFONSO C M da SILVA L C P LIMA F G M | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 16 | Effect of high levels of dietary vitamin C on the blood responses of matrinxa (Brycon amazonicus )显示文摘 | Affonso E G Silva Eda C Tavares-Dias M | 2007 | Comp Biochem Physiol A2007，147，2： | 1 |
| 17 | Effect of high levels of dietary vitamin C on the blood responses of matrinx( Brycon amazonicus) 显示文摘 | AFFONSO E G DA COSTA SILVA E TAVARES-DIAS M | 2007 | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology2007，147，2： | 1 |
| 18 | Cytogenetic analysis of coral reef fishes from Brazil(families Pomacanthidae and Chaetodontidae) 显示文摘 | Affonso P R A M Pauls W Guedes E Galetti Jr P M | 2001 | Cytologia2001，66，： | 1 |
| 19 | MW and MVar management on supply and demand side for meeting voltage stability margin criteria 显示文摘 | Carolina M Affonso Luiz C P da Silva Flavio G M Lima | 2004 | IEEE Trans on Power Systems2004，19，3： | 1 |
| 20 | Chromosomal diversification of reef fishes from genus Centropyge(Perciformes, Pomaeanthidae) 显示文摘 | Affonso P R A M Galetti Jr P M | 2005 | Genetiea2005，123，3： | 1 |
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