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	题名	作者	年代	出处	被引量
1	Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off.	B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel	2011	Asian Pacific Journal of Tropical Biomedicine2011，1，3：	3
2	Cadmi- um affects tobacco cells by a series of three waves of reactive oxygen species that contribute to cytotoxicity显示文摘	GARNIER L SIMON-PLAS F P AGNEL J P	2006	Plant Cell & Environment2006，29，10：	1
3	Species specific amino acid sequence–protein local structure relationships: An analysis in the light of a structural alphabet显示文摘	Alexandre G. de Brevern Agnel Praveen Joseph	2011	Journal of Theoretical Biology2011，，1：	1
4	Thermal step method for space charge measurements under applied DC field显示文摘	Notingher P Agnel S Toureille A	2001	IEEE Transactions on Dielectrics and Electrical Insulation2001，8，6：	1
5	Caregiver Burden in Alzheimer's Disease: Differential Associations in Adult-Child and Spousal Caregivers in the GERAS Observational Study 显示文摘	Reed C Belger M Dell' agnel!o G	2014	Dement Geriatr Cogn Dis Extra2014，4，1：	1
6	Thrombolysis or heparin in the treatment of pulmonary embolism 显示文摘	AGNELL I G BECATTIN I C KIRSCHSTEI N T	2002	Arch Intern Med2002，162，：	1
7	Electric field and space charge measurement in thick power cable insulation显示文摘	Castellon J Notingher P Agnel S		0，，03：	1
8	Insufficient duration of venous thromboembolism prophylaxis after total hip or knee replacement when compared with the time course of thromboembolic events:findings from the Global Orthopaedic Registry显示文摘	Warwick D Friedman RJ Agnel i G		0，，06：	1
9	Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement显示文摘	Lee A Agnel i G Bül er H		0，，01：	1
10	Early hemorrhagic transformation of brain infarction : rate, predictive factors, and influence on clinical outcome : results of a prospective multicenter study 显示文摘	Maurizio Paciaroni Giancarlo Agnel!i Francesco Corea	2008	Stroke2008，39，8：	1
11	Electric field and space charge measurements in thick power cable insulation显示文摘	Jereme Castellon Petru Notingher Jr Serge Agnel	2009	IEEE Electrical Insulation Magazine2009，25，5：	1
12	TSM for space charge measurements under applied DC Field显示文摘	Nothinger P J Agnel S Toureille A	2001	IEEE Transaction on Dielectrics and Electrical Insulation2001，8，6：	1
13	Electricfield and space charge Measurements in thick power cable insula-tion 显示文摘	CASTELLON J NOTINGHER P AGNEL S	2009	IEEE Electrical Insulation Magazine2009，25，3：	1
14	Thermal step method for space charge measurements under applied DC field显示文摘	Notingher P Agnel S Toureille A	2001	IEEE Transactions on Dielectrics and Electrical Insulation2001，8，6：	1
15	Electron spin resonance identification of irradiated fruits显示文摘	RAFFI J AGNEL J P	1989	Radiat Phys Chem1989，34，6：	1
16	Electron spin resonance identification of irradiated dates显示文摘	RAFFI J AGNEL J P AHMED S H	1991	Food Tec1991，34，：	1
17	The extensin multigene family responds differentially to superoxide or hydrogen peroxide in tomato cell culture显示文摘	WISNIEWSKI J P CORNILLE P AGNEL J P	1999	FEBS Lett1999，447，：	1
18	Influence of heat treatment on the space charge within an epoxy resin polymer material 显示文摘	GUERMAZI H SMAOUI H AGNEL S	2001	Polym Int2001，50，7：	1
19	pro map kinase is expressed in the pancreas and is immediately activated following cerulein hyperstimulation显示文摘	W agnel Mether W Holken T Weber W Goke D		0，，：	1
20	Predictors of mortality from pul- monary embolism And their influence on clinical man agement 显示文摘	Becattini C Agnel! G	2008	Thromb Haemost2008，，100：	1

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