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| 1 | Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives显示文摘Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every year.In the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the patients.At the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling.Nonetheless,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival advantages.Therefore,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent trials.The aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC. | Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan | 2019 | World Journal of Gastroenterology2019，25，38： | 9 |
| 2 | A Neuro-fuzzy-sliding Mode Controller Using Nonlinear Sliding Surface Applied to the Coupled Tanks System显示文摘The aim of this paper is to develop a neuro-fuzzy-sliding mode controller (NFSMC) with a nonlinear sliding surface for a coupled tank system. The main purpose is to eliminate the chattering phenomenon and to overcome the problem of the equivalent control computation. A first-order nonlinear sliding surface is presented, on which the developed sliding mode controller (SMC) is based. Mathematical proof for the stability and convergence of the system is presented. In order to reduce the chattering in SMC, a fixed boundary layer around the switch surface is used. Within the boundary layer, where the fuzzy logic control is applied, the chattering phenomenon, which is inherent in a sliding mode control, is avoided by smoothing the switch signal. Outside the boundary, the sliding mode control is applied to drive the system states into the boundary layer. Moreover, to compute the equivalent controller, a feed-forward neural network (NN) is used. The weights of the net are updated such that the corrective control term of the NFSMC goes to zero. Then, this NN also alleviates the chattering phenomenon because a big gain in the corrective control term produces a more serious chattering than a small gain. Experimental studies carried out on a coupled tank system indicate that the proposed approach is good for control applications. | Ahcene Boubakir Fares Boudjema Salim Labiod | 2009 | International Journal of Automation and computing2009，6，1： | 3 |
| 3 | Dynamic micellar enhanced uhrafiltration: use of anionic (SDS) -nonionic (NPE) system to remove Cr^3+ at low surfactant concentration 显示文摘 | Aoudia M Allal N Djennet Ahcene | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 4 | Dynamic micellar enhanced ultrafiltration: use of anionic (SDS)–nonionic(NPE) system to remove Cr 3+ at low surfactant concentration显示文摘 | Mohamed Aoudia Nora Allal Ahcene Djennet Leila Toumi | 2003 | Journal of Membrane Science2003，，1： | 1 |
| 5 | Fixed point techniques and stability for neutral nonlinear differen- tial equations with unbounded delays显示文摘 | Ahcene Djoudi Rabah Khemis | 2006 | Georgian Mathematical Journal2006，13，： | 1 |
| 6 | Dynamic micellar enhanced ultrafiltration: use of anionic(SDS)-nonionic(NPE) system to remove Cr^3+ at low surfactant concentration显示文摘 | Mohamed Aoudia Nora Allal Ahcene Djennet | 2003 | Journal of Membrane Science2003，217，： | 1 |
| 7 | ON SOLVABILITY OF THE INTEGRODIFFERENTIAL HYPERBOLIC EQUATION WITH PURELY NONLOCAL CONDITIONS显示文摘In this study,we prove the existence,uniqueness,and continuous dependence upon the data of solution to integro-differential hyperbolic equation with purely nonlocal(integral) conditions.The proofs are based on a priori estimates and Laplace transform method.Finally,we obtain the solution using a numerical technique(Stehfest algorithm) by inverting the Laplace transform. | Ahcene MERAD Abdelfatah BOUZIANI Cenap OZEL Adem KILICMAN | 2015 | Acta Mathematica Scientia2015，35，3： | 0 |
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