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| 1 | Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report显示文摘Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. The pathophysiology of IBD is probably the result of the complex interaction of genetic susceptibility and environmental influences. There is a well-known risk of thrombosis in patients with IBD. We present the case of a 53-year-old man with ulcerative colitis, who spontaneously developed intracranial sinus thrombosis that was treated with low molecular weight heparin. Literature was searched to assess the frequency and characteristics of cerebral sinus thrombosis in IBD and the role of certain etiopathological factors in such thrombotic patients. | Hasan Umit Talip Asil Yahya Celik Ahmet Tezel Gulbin Dokmeci Nermin Tuncbilek Ufuk Utku Ali Riza Soylu | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 3 | EUS diagnosis of lymphomatous polyposis显示文摘 | MD Ahmet Tezel MD Arzu Ensari MD | 2000 | Gastrointestinal Endoscopy2000，52，5： | 1 |
| 4 | Frequency Dependence of Sonophoresis显示文摘 | Ahmet Tezel Ashley Sens Joe Tuchscherer Samir Mitragotri | 2001 | Pharmaceutical Research2001，，12： | 1 |
| 5 | Frequency Dependence of Sonophoresis显示文摘 | Ahmet Tezel Ashley Sens Joe Tuchscherer Samir Mitragotri | 2001 | Pharmaceutical Research2001，，12： | 1 |
| 6 | Frequency Dependence of Sonophoresis显示文摘 | Ahmet Tezel Ashley Sens Joe Tuchscherer Samir Mitragotri | 2001 | Pharmaceutical Research2001，，12： | 1 |
| 7 | Dysphagia induced by a cervical osteophyte: a case report of cervical spondylosis显示文摘 | Kaan Uzunca Murat Birtane Ahmet Tezel | 2004 | Chinese Medical Journal2004，，3： | 0 |
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