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| 1 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 2 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase I randomised, double- blind, placebo-controlled trial 显示文摘 | Cheng Air Kang YK Chen Z | 2009 | Lancet Oncol2009，10，1： | 1 |
| 3 | Selection of Weather Parameters for Air-Conditioning System Design for Buildings with Long Thermal Lag显示文摘Two building factors-a longer thermal lag of more than one hour for building envelops and a lag of indoor radiation to convert into cooling load-have impact on the instantaneous heat input and instantaneous cooling load.So the two factors should be taken into account when selecting the weather parameters for air-conditioning system design.This paper developed a new statistic method for the rational selection of coincident solar irradiance,dry-bulb and wet-bulb temperatures.The method was applied to historic weather records of 25 years in Hong Kong to generate coincident design weather data.And the results show that traditional design solar irradiance,dry-bulb and wet-bulb temperatures may be significantly overestimated in many conditions,and the design weather data for the three different constructions is not kept constant. | GE Lian-feng1,2,LEI Ming3,CHEN You-ming1,2(1.College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China 2.Key Laboratory of Building Safety and Energy Efficiency,MOE,China (3.Aviation Theory Department,Aviation University of Air Force,Changchun,Jilin 130022,China) | 2009 | 湖南大学学报(自然科学版)2009，36，S1： | 1 |
| 4 | A study of the chemical composition and transport of marine aerosols over the ocean near China显示文摘In this paper the authors cite the aerosol samples collected with a KA-200 Anderson cascade Impactor and a KB-120 sampler during the first cruise of the Kuroshio investigation operated by the People’s Republic of China and Japan cooperative program, from July 23 to August 21, 1987. The concentration size distributions and composition of marine aerosols over the Kuroshio area are analyzed. Neutron activation analysis is used to determine the elemental composition of the aerosols. The authors also discuss some characteristics of marine aerosols relating to long-range transport of crustal and anthropogenic elements from the continent to the remote ocean. Analytical results indicate that elements Al, Fe, Sc and Sb over this area are obviously influenced by the continent of Asia, and the size distributions are changed after long-range transport. The concentration of large particles increase. The concentrations of the elements C1 and Na are closely related to ocean conditions; the source of the elements Cl | Zhang Ni, Zhou Mingyu, Lu Naiping, F. P. Parungo, Wen Yupu, Yang Shaojing, Yang Yinan and Chen Binru National Research Center for Marine Environmental Forecasts, State Oceanic Administration, Beijing, ChinaNational Oceanic and Atmospheric Administration, Environmental Research Laboratories, Air Resources Laboratory, Boulder,CO, U.S. A.Academy of Meteorological Sciences, State Meteorological Administration, Beijing, ChinaInstitute of High Energy Physics, Academia Sinica, Beijing, China | 1991 | Acta Oceanologica Sinica1991，10，3： | 1 |
| 5 | A distributed RSS-based localization using a dynamic circle expanding mechanism显示文摘 | Jiang Joe Air Zheng Xiangyao Chen Yuan | 2013 | IEEE Sensors Journal2013，13，10： | 1 |
| 6 | Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study显示文摘 | Bhuiyan AIR Srinivasan SR Chen Wei | 2008 | Metabolism Clinical and Experimental2008，57，： | 1 |
| 7 | Research on the Speech Coding Algorithm at 1200bit/s显示文摘ResearchontheSpechCodingAlgorithmat1200bit/sChenXinfuWuJia’an(AirForceTelecommunicationsEngineringInstitute,Xi’an710077)Abstr... | Chen Xinfu Wu Jia’an (Air Force Telecommunications Engineering Institute, Xi’an 710077) | 1998 | 通信学报1998，19，5： | 1 |
| 8 | A NewAdap- tive PMU Based Protection Scheme for Transposed/untransposed ParallelTransmission Lines 显示文摘 | CHEN Ching - shan LIU Chih - wen JIANG Joe - air | 2002 | IEEE Trans on Power Systems2002，17，2： | 1 |
| 9 | An Improved Functional Hierarchy Frame Model for System Maintainability显示文摘By means of analogy, this paper analyses the present functional hierarchy frame model for system maintainability, and presents an improved model. Practical application indicates that the improved model is visualized, more convenient and perfected over the pervious models. | CHEN Dai Lin, CHEN Dong lin, WANG Ru gen, ZHU Xue ping College of Engineering, Air Force University of Engineering, Xi′an 710038, P.R.China | 2003 | International Journal of Plant Engineering and Management2003，8，4： | 0 |
| 10 | DYNAMIC OPTIMIZATION OF THERMAL STRUCTURE显示文摘DYNAMICOPTIMIZATIONOFTHERMALSTRUCTUREChenJifeng;DuanDegao(8-thDep,NorthwesternPolytechnicalUniversity,Hi'an,China,710072)Wang... | Chen Jifeng Duan Degao(8-th Dep, Northwestern Polytechnical University, Hi’an, China, 710072)Wang Jingen(3-rd Dep, Air Force Missiie Institute, Shaanxi, China, 7 1 3800) | 1994 | Chinese Journal of Aeronautics1994，7，3： | 0 |
| 11 | Scheme of Cooperative Spectrum Sensing Based on Adaptive Decision Fusion Algorithm显示文摘Spectrum sensing is one of the core technologies for cognitive radios(CR),where reliable detection of the signals of primary users(PUs) is precondition for implementing the CR systems.A cooperative spectrum sensing scheme based on an adaptive decision fusion algorithm for spectrum sensing in CR is proposed in this paper.This scheme can estimate the PU prior probability and the miss detection and false alarm probabilities of various secondary users(SU),and make the local decision with the Chair-Varshney rule so that the decisions fusion can be done for the global decision.Simulation results show that the false alarm and miss detection probabilities resulted from the proposed algorithm are significantly lower than those of the single SU,and the performance of the scheme outperforms that of the cooperative detection by using the conventional decision fusion algorithms. | Xing-Xiong Xu,Li-Min Wu,and Wei Chen,the Department of Communication and Information System,Air Force Radar Academy,Wuhan 430019,China | 2012 | Journal of Electronic Science and Technology2012，10，1： | 0 |
| 12 | Detection of Early Noise-Induced Hearing Impairment in Pilots显示文摘Objective To detect early signs of noise-induced hearing loss(NIHL) in military pilots without hearing complaints. Methods Pure tone audiometry and acoustic reflex thresholds were tested in 36 military pilots (72 ears) with noise exposure history but no complaints of hearing loss. Conventional test frequencies (0.25-8 kHz) and extended high frequencies (EHF, 10 and 12.5 kHz) were included in audiometry. White noise and pure tones at 0.5, 1, 2, and 4 kHz were used for acoustic reflex tests. Twenty normal hearing subjects(40 ears) with no exposure to occupational noise were used as controls. Results Pure tone thresholds at all conventional frequencies and at EHFs were elevated in the pilots, with the maximum shift at 4 kHz, compared with controls (p < 0.01). The pilots also showed elevated ART to white noise and decreased differentials between white noise and pure tone ARTs (p< 0.01). Conclusion Early signs of NIHL are present in some symptom-free military pilots. High frequency hearing threshold shift, elevated white noise ART and decreased differential between white noise and pure tone ARTs may be objective indicators of early NIHL. | WANG En-tong, GONG Wei-xi, CHEN Wei, MA Xiao-li, XIA Hui, CHEN Jun Department of Otolaryngology-Head and Neck Surgery, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Beijing 100036, P.R.China | 2008 | Journal of Otology2008，3，2： | 0 |
| 13 | The Aeronautic Equipment RMS Management, Monitoring System and Software Realization显示文摘This paper introduces the theory of system engineering on materiel into themanagement and monitoring of reliability,maintainability and supportability (RMS) activiries inthe aeronauric equipment’s life cycle. In order to assure the science of RMS management, itanalyzes the contents of RMS activistes in a life cycle, provides the model of management andmonitoring, and discusses the software realization of the management and monitoring system. | Chen Yunxiang Zhang Zhengmin Tian Tao(Management Department of the Air Force College of EngineeringXi’an, P.R. China) | 1999 | International Journal of Plant Engineering and Management1999，4，1： | 0 |
| 14 | An Analysis of the Differences between Old and New Maintenance Concepts显示文摘This paper attempts to concentrate on the eight basic principles of reliability-centeredmaintenance, and discusses respectively the differences between old and new maintenanceconcepts in eight aspects, i.e., function of rework at hard time, potential failure and funcrionalfailure, function of preventive maintenance, change of failure consequence, determinarion ofpreventive maintenance work and formulation of initial preventive maintenance program, andperfection of preventive maintenance program. | Zheng Dongliang Chen Xuechu(Department of Aeronautic Engineering Management,)(The Air Force College of Engineering) | 1999 | International Journal of Plant Engineering and Management1999，4，1： | 0 |
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