|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF显示文摘Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive procedures.Point-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ratio.Methods:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion requirements.We assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC strategy.Results:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion algorithms.Of 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 patients.Correction of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,respectively.Conclusions:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical bleeding.Trial Registration:NCT04332484. | Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 7 |
| 2 | Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract显示文摘Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles (<5m) using a Flow Past Nose Only Inhalation Chamber at the rate of -10 mg/m3 respirable mass for 5 h. Lung bronchoalveolar lavage (BAL) fluid collected between 48 and 72 h was subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA. Lung histopathology was performed to evaluate lung injury. Results Inhalation of silica increased the level of tumor necrosis factor-a (TNF-a), and of the 66 and 63 kDa peptides in the BAL fluid in comparison to sham-treated control. Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-a in the BAL fluid, but the 66 and 63 kDa peptides remained unchanged. The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion, edema and infiltration of nucleated cells in the interstitial alveolar spaces, and thickening of alveolar septa in mouse lung. Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice. | BHOLA NATH PAUL*,1, ANAND PRAKASH*, SIRISH KUMAR*, AJAY K. YADAV*, U. MANI+, ASHOK K. SAXENA*, ANAND PRAKASH SAHU#, KEWAL LAL+, AND KALYAN K. DUTTA+ *Immunobiology Laboratory +Inhalation Toxicology Laboratory #Preventive Toxicology Laboratory Industrial Toxicology Research Centre, M.G.Marg, Lucknow 226001, U.P. India | 2002 | Biomedical and Environmental Sciences2002，15，3： | 1 |
| 3 | Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis显示文摘 | Ajay Yerramasu Damini Dey Shreenidhi Venuraju Dhakshinamurthy Vijay Anand Satvir Atwal Roger Corder Daniel S. Berman Avijit Lahiri | 2011 | Atherosclerosis2011，，1： | 1 |
| 4 | Lipodystrophy and metabolic complications of highly active antiretroviral therapy显示文摘 | Ankit Parakh Anand Prakash Dubey Ajay Kumar Anshu Maheshwari | 2009 | The Indian Journal of Pediatrics2009，，10： | 1 |
| 5 | Three-dimensional spatial and temporal temperature imaging in gel phantoms using backscattered ultrasound显示文摘 | Ajay Anand David Savery Christopher Hall | 2007 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2007，54，1： | 1 |
| 6 | Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis显示文摘 | Ajay Yerramasu Damini Dey Shreenidhi Venuraju Dhakshinamurthy Vijay Anand Satvir Atwal Roger Corder Daniel S. Berman Avijit Lahiri | 2011 | Atherosclerosis2011，，1： | 1 |
| 7 | The COVID-19 Pandemic and Mental Health Concerns on Twitter in the United States显示文摘Background.During the COVID-19 pandemic,mental health concerns(such as fear and loneliness)have been actively discussed on social media.We aim to examine mental health discussions on Twitter during the COVID-19 pandemic in the US and infer the demographic composition of Twitter users who had mental health concerns.Methods.COVID-19-related tweets from March 5th,2020,to January 31st,2021,were collected through Twitter streaming API using keywords(i.e.,“corona,”“covid19,”and“covid”).By further filtering using keywords(i.e.,“depress,”“failure,”and“hopeless”),we extracted mental health-related tweets from the US.Topic modeling using the Latent Dirichlet Allocation model was conducted to monitor users’discussions surrounding mental health concerns.Deep learning algorithms were performed to infer the demographic composition of Twitter users who had mental health concerns during the pandemic.Results.We observed a positive correlation between mental health concerns on Twitter and the COVID-19 pandemic in the US.Topic modeling showed that“stay-at-home,”“death poll,”and“politics and policy”were the most popular topics in COVID-19 mental health tweets.Among Twitter users who had mental health concerns during the pandemic,Males,White,and 30-49 age group people were more likely to express mental health concerns.In addition,Twitter users from the east and west coast had more mental health concerns.Conclusions.The COVID-19 pandemic has a significant impact on mental health concerns on Twitter in the US.Certain groups of people(such as Males and White)were more likely to have mental health concerns during the COVID-19 pandemic. | Senqi Zhang Li Sun Daiwei Zhang Pin Li Yue Liu Ajay Anand Zidian Xie Dongmei Li | 2022 | Health Data Science2022，，1： | 1 |
| 8 | Spatio-temporal distribution of extreme weather events in India显示文摘 | Ajay Singha Anand Patwardhan | 2012 | APCBEE Procedia2012，1，： | 1 |
| 9 | Single-stage repair for rectovestibular fistula without opening the fourehette显示文摘 | Vijai Datta Upadhyaya Ajay N Gangopadhyay Anand Pandey | 2008 | Journal of pediatric sugery2008，43，： | 1 |
| 10 | Twenty years' experience of steroids in infantile hemangioma-a developing country's perspective 显示文摘 | Anand Pandey Ajay Narayan Gangopadhyay Saroj Chooramani Gopal | 2009 | Journal of Pediatric Surgery2009，44，4： | 1 |
| 11 | 道德对印度商业的影响显示文摘以印度为例,有人认为新兴的东方是不道德的,西方是道德的,发展中的市场和发达的市场之间存在一个三角洲,新兴市场要成为金融精英必须打破一个屏障。事实真的如此简单吗? | Ajay Anand Kavitha Cherian Arpan Gautam Roopak Majmudar Arzan Raimawala | 2012 | 新营销2012，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员