1篇
您的检索式：作者名="Ajit Tharakan"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical outcomes and gut microbiota analysis of severe alcohol-associated hepatitis patients undergoing healthy donor fecal transplant or pentoxifylline therapy:single-center experience from Kerala显示文摘Background Severe alcohol-associated hepatitis(SAH)patients with infections have a high short-term mortality rate.Gut microbiota dysbiosis plays an important role in the pathogenesis of SAH.Preliminary studies have demonstrated long-term benefits with healthy donor fecal microbiota transplantation(FMT).Data on FMT compared with pentoxifylline for SAH and relevant gut microbial changes are lacking in literature.Methods From January 2019 to February 2021,retrospective analysis of a single hospital’s records revealed 47 SAH patients undergoing FMT(100mL/day via nasoduodenal tube for 7days)and 25matched patients receiving pentoxifylline(400mg/8 h for 28days).The primary end point was a 6-month survival rate.Secondary end points included incidence of ascites,hepatic encephalopathy,infections,acute kidney injury,and gutmicrobiota changes between post-therapy groups.Biomarker discovery and network analysis were also performed to identify significant taxa of gutmicrobiota in post-treatment groups in retrospectively stored stool samples.Results All were males.The 6-month survival rate was higher in the patients undergoing FMT than in patients receiving pentoxifylline(83.0%vs 56.0%,P=0.012).At the end of 6-month follow-up,the incidences of clinically significant ascites(56.0%vs 25.5%,P=0.011),hepatic encephalopathy(40.0%vs 10.6%,P=0.003),and critical infections(52.0%vs 14.9%,P<0.001)in patients administered pentoxifylline were significantly higher than those in patients treated with FMT.At 3 months,biomarker analysis revealed a significant abundance of Bifidobacterium and Eggerthella in the FMT group and the pentoxifylline group,respectively.At 6 months,Bifidobacterium in the FMT group and pathogenic Aerococcaceae in the pentoxifylline group were notable.Network analysis showed beneficial taxa(Bifidobacterium)as a central influencer in those undergoing FMT at 6 months.Conclusions Healthy donor FMT improved survival rate and reduced liver-related complications compared with pentoxifylline.These clinical benefits were associated with favorable modulation of intestinal bacterial communities.Difficult-totreat SAH patients may be safely bridged to transplantation using FMT.Controlled trials evaluating long-term outcomes are an unmet need. | Cyriac Abby Philips Rizwan Ahamed Sasidharan Rajesh Shobhit Singh Ajit Tharakan Jinsha K.Abduljaleel Philip Augustine | 2022 | Gastroenterology Report2022，10，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员