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| 1 | Molecular basis for identification of species/isolates of gastrointestinal nematode parasites显示文摘Gastrointestinal(GI) parasitism is the most serious constraint throughout the world in small ruminants which causes significant production loss in animals.GI parasites are major contributor to reduce productivity in terms of meat,milk and wool in animals.Control of GI parasite is done primarily by anthelmintic treatment where choice and schedule of treatment is done after identification and quantitation of individual parasite.Identification of GI parasites is done through microscopic method by identifying specific morphological characteristics of egg and larva(L3).Since most of parasite eggs are having similar morphological characteristics, identification up to species level through microscopy is not possible in most of cases.To address this issue,molecular techniques are the viable alternative for identification of species as well as molecular level differences within a species(isolates) of parasites.Different DNA based molecular techniques viz.PCR,AFLP,RAPD,RFLP,PCR-SSCP,real time PCR,DNA microarray etc.have been used for identification and to assess the genetic diversity among parasite population.For identification of species,the characteristic sequence of genomic DNA of different species should differ to allow the delineation of species,but at the same time,no/minor variation within the species should exist.In contrast,for purpose of identifying population variants(strains/isolates), a considerable degree of variation in the sequence should exist within a species.Various target regions,including nuclear ribosomal DNA(rDNA),mitochondrial DNA(mtDNA) or repetitive DNA elements(microsatellite loci),which show considerable variation in the number of repeats within individuals have been employed to achieve the identification of parasites species or strain. | Ahmed M Singh MN Bera AK Bandyopadhyay S Bhattacharya D | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 6 |
| 2 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 3 | Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action显示文摘AIM: To evaluate the protective activity of allylpyrocatechol (APC), the major antioxidant constituent of Piper betel, against the indomethacin-induced stomach ulceration in the rat model and correlates with its antioxidative and mucin protecting properties. METHODS: Male Sprague-Dawley rats were divided into five groups. Normal control rats (group Ⅰ) were given the vehicle oral dose of gum acacia in distilled water (1 mL per rat); ulcerated control and treated rats (groups Ⅱ-Ⅴ) were given a single dose of indomethacin (30 mg/kg body wt.); group Ⅱ rats were sacrificed 4 h after indomethacin administration; groups Ⅲ-Ⅴ rats were given the vehicle (1 mL per rat) or APC (2 mg/kg body wt.) or misoprostol (1.43 μg/kg body wt.) once daily by oral intubation for 7 d starting from 4 h after the indomethacin administration. After 7 d, the stomach tissues were excised for histological examination and biochemical analysis. RESULTS: Treatment with APC (2 mg/kg body wt per day) and misoprostol (1.43 μg/kg body wt per day) for 7 d could effectively heal the stomach ulceration as revealed from the ulcer index and histopathological studies. Compared to the zero day ulcerated group, treatment with APC and misoprostol reduced the ulcer index by 93.4% and 85.4% respectively (P < 0.05). Both APC and misoprostol accelerated ulcer healing observed in natural recovery (P < 0.05), their respective healing capacities not being significantly different. The healing capacities of APC and misoprostol could be attributed to their antioxidant activity as well as the ability to enhancethe mucin content of the gastric tissues. Compared to the ulcerated untreated rats, those treated with APC and misoprostol showed near normal MDA levels, while the protein levels were 86% and 78% of the normal value respectively (P < 0.05). Likewise, both APC and misoprostol increased the SOD, catalase, and mucin levels significantly (P < 0.05), the effect of APC being better. CONCLUSION: APC can protect indomethacin-induced gastric ulceration due to its antioxidative and mucin protecting properties. | S Bhattacharya D Banerjee AK Bauri S Chattopadhyay SK Bandyopadhyay | 2007 | World Journal of Gastroenterology2007，13，27： | 4 |
| 4 | Pacitaxel and its formulation显示文摘 | Singla AK Garg A Aggarwal D | 2002 | Lnt J Pharm2002，235，12： | 1 |
| 5 | Three dimensional structure of human C-reactive protein显示文摘 | Cheetham GM Holden D | 1996 | Nature Struct Biol1996，3，4： | 1 |
| 6 | Paclitaxel and its formulations显示文摘 | Garg A Aggarwal D | 2002 | Int J Pharm2002，235，3： | 1 |
| 7 | Cytokine-induced pro-apoptotic gene expression in insulin-producing cells is related to rapid,sustained and non-oscillatory NF-κB activation显示文摘 | Cardozo AK Crispim D | 2006 | Mol Endocrinol2006，20，： | 1 |
| 8 | High aldehyde dehydrogenase and expression of cancer stein cell markers selects for breast cancer cells with enhanced malignant and metastatic ability 显示文摘 | Croker AK Goodale D Chu J | 2008 | J Cell Mol Med2008，4，4： | 1 |
| 9 | Distinctiveness of genotypes of Helicobacter pylori in Calcutta,India显示文摘 | Mukhopadhyay AK Kersulyte D Jeong JY | 2000 | J Bacteriol2000，182，11： | 1 |
| 10 | 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells 显示文摘 | Bengtsson AK Ryan EJ Giordano D | 2004 | Blood2004，104，5： | 1 |
| 11 | Serum cholesterol and mortality in patients with multiple organ failure显示文摘 | Fraunberger P Nagel D Walli AK | 2000 | Crit Care Med2000，28，： | 1 |
| 12 | Hospital-acquired neonatal infections in developing countries显示文摘 | Zaidi AK Huskins WC Thaver D Bhutta ZA Abbas Z Gold- mann DA | 2005 | Lancet2005，365，9465： | 1 |
| 13 | Study of the extent of ocular absorption of acetazolamide from a developed niosomal formulation,by microdialysis sampling of aqueous humor显示文摘 | Aggarwal D Pal D Mitra AK | | 0，，： | 1 |
| 14 | Rapid regulation of depression - related behaviours by control of midbrain dopamine neurons显示文摘 | Chaudhury D Walsh JJ Friedman AK | 2013 | Nature2013，493，7433： | 1 |
| 15 | Association between annual visit-to-visit blood pressure variability and stroke in postmenopausal women:datafrom the Women' s Health Initiative显示文摘 | Shimbo D Newman JD Aragaki AK | 2012 | Hypertension2012，60，3： | 1 |
| 16 | How early laparoscopic treatment of cholecystitis显示文摘 | Madan AK Aliabadi-Wahles Tesi D | | 0，，： | 1 |
| 17 | Acute psychosis:a presentation of cyanocobalamin deficiency megaloblastic ane-mia显示文摘 | Tripathi AK Verma SP Himanshu D | | 0，，3： | 1 |
| 18 | Efficacy, safety and treatment satisfaction of Glimepiride vs Sitagliptin in combination with Metformin in type 2 diabetes mellitus 显示文摘 | Kumar S Pathak AK Saikia D | 2015 | Journal of Clinical & Diagnostic Research Jcdr2015，9，12： | 1 |
| 19 | Patient satisfaction with the bone-anchored hearing aid: a 14-year experience 显示文摘 | Badran K Bunstone D Arya AK | 2006 | Otology & Neurotology2006，27，： | 1 |
| 20 | Electrochemical oxidation of quercetin in hydro-alcoholic solution显示文摘 | TIMBOLA A K SOUZA C D D GIACOMELLI C et ak | 2006 | J Braz Chem Soc2006，17，1： | 1 |
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