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| 1 | Use of granulocyte/monocytapheresis in ulcerative colitis:A practical review from a European perspective显示文摘Half of the patients with ulcerative colitis require at least one course of systemic corticosteroids in their lifetime.Approximately 75%of these patients will also require immunosuppressive drugs(i.e.,thiopurines or biological agents)in the mid-term to avoid colectomy.Immunosuppressive drugs raise some concerns due to an increased risk of serious and opportunistic infections and cancer,particularly in elderly and co-morbid patients,underlining the unmet need for safer alternative therapies.Granulocyte/monocytapheresis(GMA),a CE-marked,non-pharmacological procedure for the treatment of ulcerative colitis(among other immune-mediated diseases),remains the only therapy targeting neutrophils,the hallmark of pathology in ulcerative colitis.GMA has proven its efficacy in different clinical scenarios and shows an excellent and unique safety profile.In spite of being a first line therapy in Japan,GMA use is still limited to a small number of centres and countries in Europe.In this article,we aim to give an overview from a European perspective of the mechanism of action,recent clinical data on efficacy and practical aspects for the use of GMA in ulcerative colitis. | Eugeni Domènech Joan-Ramon Grífols Ayesha Akbar Axel U Dignass | 2021 | World Journal of Gastroenterology2021，27，10： | 2 |
| 2 | Current organ preservation solutions for liver preservation: experimental comparison显示文摘 | Tolba RH Akbar S Puetz U | 2000 | Transplant Proc2000，32，1： | 1 |
| 3 | Compressed Channel Sensing: a New Approach to Estimating Sparse Multipath Channels显示文摘 | Bajwa W U Jarvis H Akbar M S | 2010 | Proceedings of the IEEE2010，98，6： | 1 |
| 4 | Direct solubilization of enzyme aggregates with enhanced activity in nonaqueous media 显示文摘 | AKBAR U ASCHENBRENNER C D HARPER M R | 2007 | Biotechnol Bioeng2007，96，6： | 1 |
| 5 | Rate andprognosis of patients under conscious sedation requiringemergent intubation during neuroendovascular procedures显示文摘 | Hassan AE Akbar U Chaudhry SA | 2013 | AJNR Am J Neuroradiol2013，34，7： | 1 |
| 6 | Joint source-channel communication for distributed estimation in sensor networks显示文摘 | Waheed U Bajwa Jarvis D Haupt Akbar M Sayeed Robert D Nowak | 2007 | IEEE Trans Inform Theory2007，53，10： | 1 |
| 7 | Increased prevalence of temporary cardiac pacing in people with epilepsy 显示文摘 | Akbar U Rincon F Caftan M | 2012 | Seizure2012，21，7： | 1 |
| 8 | Spatial patterns in gypsum requirement before and after gypsum application显示文摘 | Aman U B Abroad B Akbar H G | 2000 | Pakistan Journal of Biological Science2000，3，10： | 1 |
| 9 | Direct solubilization of enzyme aggregates with enhanced activity in nonaqueous media显示文摘 | AKBAR U ASCHENBRENNER C D HARPER M R | 2007 | Biotechnol Bioeng2007，96，6： | 1 |
| 10 | Effectiveness of heat and mass transfer on mixed convective peristaltic motion of nanofluid with irreversibility rate显示文摘Entropy generation is one of the key features in analysis as it exhibits irreversibility of the system. Therefore, the present study investigates the entropy generation rate in a mixed convective peristaltic motion of a reactive nanofluid through an asymmetrical divergent channel with heat and mass transfer characteristics. The endorsed nanofluid model holds thermophoresis and Brownian diffusions. Mathematical modeling is configured under the effects of mixed convection, heat generation/absorption and viscous dissipation. A chemical reaction is also introduced for the description of mass transportation. The resulting system of differential equations is numerically tackled by employing the Shooting method. The findings reveal that entropy generation rises by improving the Brownian motion and thermophoresis parameters. The temperature of the nanofluid decreases due to rising buoyancy forces caused by the concentration gradient. The concentration profile increases by increasing the chemical reaction parameter. The velocity increases by enhancing the Brownian motion parameter. | Y Akbar F M Abbasi U M Zahid S A Shehzad | 2021 | Communications in Theoretical Physics2021，73，10： | 0 |
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