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| 1 | TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation显示文摘Transforming growth factor-beta(TGF-β)/bone morphogenetic protein(BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcomes, i.e., skeletal, extra skeletal anomalies, autoimmune, cancer, and cardiovascular diseases. Phosphorylation of TGF-β(I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways, including transcription factor Runx2. The signaling network in skeletal development and bone formation is overwhelmingly complex and highly time and space specific.Additive, positive, negative, or synergistic effects are observed when TGF-β/BMP interacts with the pathways of MAPK, Wnt, Hedgehog(Hh), Notch, Akt/m TOR, and mi RNA to regulate the effects of BMP-induced signaling in bone dynamics. Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, mi RNAs are regulators, and b-catenin is a mediator/regulator within the extensive intracellular network. This review focuses on the activation of BMP signaling and interaction with other regulatory components and pathways highlighting the molecular mechanisms regarding TGF-β/BMP function and regulation that could allow understanding the complexity of bone tissue dynamics. | Md Shaifur Rahman Naznin Akhtar Hossen Mohammad Jamil Rajat Suvra Banik Sikder M Asaduzzaman | 2015 | Bone Research2015，3，1： | 53 |
| 2 | Nonischemic sudden tachycarrhythemic death in atherosclerotic heart disease显示文摘 | Meissner MD Akhtar M Lehmann MH | 1995 | Circulation1995，84，： | 1 |
| 3 | Hyponatremic hypertensive syndrome-a retrospective cohort study显示文摘AIM To ascertain the frequency of hyponatremic hypertensive syndrome(HHS) in a cohort of children with hypertensive emergency in a tertiary pediatric hospital.METHODS A retrospective review was undertaken among children with hypertensive emergency admitted in our tertiary children hospital between June 2014 and December 2015 with an aim to identify any children with HHS. Three children with HHS were identified during this period. RESULTS The 3 patients with HHS presented with hypertensive emergency. They were initially managed with Labetalol infusion and thereafter switched to oral anti-hypertensives(combination of Nifedipine sustained release,Hydralazine and Beta Blocker). All 3 were diagnosed to have unilateral renal artery stenosis. One child was lost to follow up,whereas the other 2 underwent renal angioplasty which was followed with normalization of blood pressure.CONCLUSION Despite activation of renin angiotensin axis secondary to renal artery stenosis,these groups of children have significant hyponatremia. Renal re-vascularisation produces excellent results in most of them. | Devdeep Mukherjee Rajiv Sinha Md Shakil Akhtar Agni Sekhar Saha | 2017 | World Journal of Nephrology2017，6，1： | 1 |
| 4 | Lower gastrointestinal bleeding in eldedy patients显示文摘 | Abbasi J Akhtar MD MECP | 2003 | Jamda2003，11，12： | 1 |
| 5 | Monovalent cationinduced conformational change in glucose oxidase leading to stabilization of the enzyme显示文摘 | Ahmad A Akhtar Md S Bhakuni V | 2001 | Biochemistry2001，40，： | 1 |
| 6 | Nonischemic sudden tachycarrhythemic death in atherosclerotic heart disease显示文摘 | Akhtar M Lehmann MH | 1995 | Circulation1995，84，： | 1 |
| 7 | The delivery of antisense therapeutics显示文摘 | AKHTAR S HUGHES MD KHAN A | 2000 | Adv Drug Deliv Rev2000，44，1： | 1 |
| 8 | The delivery of antisense therapeutics 显示文摘 | Akhtar S Hghes MD Khan A | 2000 | Adv Drag Del Rev2000，44，1： | 1 |
| 9 | The delivery of antisense therapeutics显示文摘 | Akhtar S Hghes MD Khan A | 2000 | Adv Drug Deliv Rev2000，44，1： | 1 |
| 10 | The delivery of antisense therapeutics显示文摘 | Akhtar S Hughes MD Khan A | 2000 | Adv Drug Deliv Rev2000，44，1： | 1 |
| 11 | The delivery of antisense therapeutics显示文摘 | Akhtar S Hughes MD Khan A | 2000 | Adv Drug Deliv Rev2000，44，1： | 1 |
| 12 | Nonischemic sudden tachy-arrhythemic death in atherosclerotic heart disease显示文摘 | Meissner MD Akhtar M Lehmann MH | 1995 | Circulation1995，84，： | 1 |
| 13 | Risk factors of diabetic retinopathy in Bangladeshi type 2 diabetic patients显示文摘 | Kazi R. Ahmed Md N. Karim Mohammad S. Bukht Bishwajit Bhowmik Amitava Acharyya Liaquat Ali Akhtar Hussain | 2012 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews2012，，4： | 1 |
| 14 | Comparative phytochemical,thin layer chromatographic profiling and antioxidant activity of extracts from some Indian herbal drugs显示文摘Natural antioxidants play a significant role to prevent cell breaking and regenerate cells.Three plants native to India named dwarf morning-glory(Evolvulus alsinoides),Indian banyan(Ficus bengalensis)and chicory(Chicorium intybus)are used as medicine in India traditionally to treat diseases.The aim of this study is to evaluate and compare the antioxidant activity as well as to compare phytochemical profiles of the aqueous extracts of the selected three plants.The dried plant powder was extracted with ethanol individually by using the Soxhlet method for eight hours and the solvent was evaporated under reduced pressure.Similarly,the air-dried powder was ex-tracted with water,and the water was evaporated.The thin layer chromatography(TLC)profile of the extracts was determined by using TLC densitometer and the antioxidant activity was deter-mined by the conventional 2,2-diphenyl-1-picrylhydrazyl(DPPH)method.The TLC profile shows that there are no similarities of retention factor(R f)values among the plant extracts which means all three plants contain different chemical compounds.The antioxidant activities of the aqueous extracts at different concentrations show different antioxidant activities.Percentage inhibition is dose dependent,as doses are increasing then percentage inhibition is also increasing for all three plant extracts.Among the selected plants,the highest activity was found in C.intybus and the lowest was in E.alsinoides.The order of the antioxidant activity among the selected plants was C.intybus | Md Sohail Akhtar Mohamed Rafiullah Wegdan Aly Shehata Amzad Hossain Mohammed Ali | 2022 | Journal of Bioresources and Bioproducts2022，7，2： | 0 |
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