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| 1 | Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China显示文摘Background:Leptospirosis morbidity and mortality rates in China have decreased since the 2000s.Further analyses of the spatiotemporal and demographic changes occurring in the last decade and its implication on estimates of disease burden are required to inform intervention strategies.In this study,we quantified the epidemiological shift and geographical heterogeneity in the burden of leptospirosis during 2005-2015 in China.Methods:We used reported leptospirosis case data from 1st January 2005 to 31st of December 2015 that routinely collected by the China Information System for Disease Control and Prevention(CISDCP)to analyze the epidemiological trend and estimate the burden in terms of disability-adjusted life-years(DALYs)over space,time,and demographical groups.Results:A total of 7763 cases were reported during 2005-2015.Of which,2403(31%)cases were the laboratoryconfirmed case.Since 2005,the notified incidence rate was gradually decreased(P<0.05)and it was relatively stable during 2011-2015(P>0.05).During 2005-2015,we estimated a total of 10313 DALYs were lost due to leptospirosis comprising a total of 1804 years-lived with disability(YLDs)and 8509 years-life lost(YLLs).Males had the highest burden of disease(7149 DALYs)compared to females(3164 DALYs).The highest burden estimate was attributed to younger individuals aged 10-19 years who lived in southern provinces of China.During 2005-2015,this age group contributed to approximately 3078 DALYs corresponding to 30%of the total DALYs lost in China.Yet,our analysis indicated a declining trend in burden estimates(P<0.001)since 2005 and remained relatively low during 2011-2015.Low burden estimates have been identified in the endemic regions where infections principally distributed.Most of the changes in DALY estimates were driven by changes in YLLs.Conclusions:In the last 11-years,the burden estimates of leptospirosis have shown a declining trend across the country;however,leptospirosis should not be neglected as it remains an important zoonotic disease and potentially affecting the young and productive population in economically less-developed provinces in southern of China.In addition,while in the last five years the incidence has been reported at very low-level,this might not reflect the true incidence of leptospirosis.Strengthened surveillance in the endemic regions is,hence,substantially required to capture the actual prevalence to better control leptospirosis in China. | Pandji Wibawa Dhewantara Abdullah AMamun Wen-Yi Zhang Wen-Wu Yin Fan Ding Danhuai Guo Wenbiao Hu Federico Costa Albert Icksang Ko Ricardo JSoares Magalhaes | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 2 | Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China显示文摘Hyperphenylalaninemia 是在 15 000 实时出生影响约 1 的新陈代谢的最普通的先天的错误之一。在汉语之中, BH4 缺乏导致 hyperphenylalaninemia 比在白种人普通得多。准确诊断为治疗并且基因建议是重要的。在 2000,为苯酮尿的新生的屏蔽由在在整个整个国家的中国的法律是强制的。然而,它还没在香港特别行政区的新生的屏蔽节目被包括,中国。在香港汉语之中的 hyperphenylalaninemia 上的出版数据大部分正在缺乏。我们与严重 6-pyruvoyl-tetrahydropterin synthase (PTPS ) 报导一个 1 岁的香港中国女孩缺乏。病人与婴儿的 hypotonia 介绍了并且作为服的麻痹被误诊。她有的很温和的 hyperphenylalaninemia (95 mol/L ) ,显著地高的 phenylalnine-to-tyrosine 比率(3.1 ) ,和 1109 mlU/L 的提高的催乳激素。基因分析证实了同型结合的已知的引起疾病的变化磅 NM_000317.1:c.259CT;NP_000308.1:p。在 proband 的 P87S。根据我们的本地经验,当 PTPS 缺乏的 hyperphenylalaninemia 线索的估计的流行被报导在 29 542 实时出生,不是本氨基丙酸 hydroxylase 的一个单个案例是 1 时,缺乏被报导了。而且,有在社区以及在医药专业人员之中的继承新陈代谢的疾病的了解的一般缺乏。很经常,临床的怀疑的一个低索引将在诊断,多重不必要、昂贵的调查,延长病态和焦虑导致延期到影响的家庭。我们强烈建议为 hyperphenylalaninemia 屏蔽的那个扩展新生儿应该为在香港特别行政区出生的每个婴儿被实现,中国。 | Chloe Miu Mak Chun-hung Ko Ching-wan Lam Wai-ling Lau Wai-kwan Siu Sammy Pak-lam Chen Chun-yiu Law Chi-kong Lai Chak-man Yu Albert Yan-wo Chan | 2011 | Chinese Medical Journal2011，，16： | 2 |
| 3 | Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil显示文摘 | Marcos Tucunduva de Faria Michael S. Calderwood Daniel A. Athanazio Alan J.A. McBride Rudy A. Hartskeerl Martha Maria Pereira Albert I. Ko Mitermayer G. Reis | 2008 | Acta Tropica2008，，1： | 1 |
| 4 | Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans显示文摘 | Daniel A. Athanazio Everton F. Silva Cleiton S. Santos Gustavo M. Rocha Marcos A. Vannier-Santos Alan J.A. McBride Albert I. Ko Mitermayer G. Reis | 2007 | Acta Tropica2007，，： | 1 |
| 5 | Comparative analysis of DNA extraction protocols for ancient soft tissue museum samples显示文摘DNA studies of endangered or extinct species often rely on ancient or degraded remains.The majority of ancient DNA(aDNA)extraction protocols focus on skeletal elements,with skin and hair samples rarely explored.Similar to that found in bones and teeth,DNA extracted from historical or ancient skin and fur samples is also extremely fragmented with low endogenous content due to natural degradation processes.Thus,the development of effective DNA extraction methods is required for these materials.Here,we compared the performance of two DNA extraction protocols(commercial and custom laboratory aDNA methods)on hair and skin samples from decades-old museum specimens to Iron Age archaeological material.We found that apart from the impact sample-specific taphonomic and handling history has on the quantity and quality of DNA preservation,skin yielded more endogenous DNA than hair of the samples and protocols tested.While both methods recovered DNA from ancient soft tissue,the laboratory method performed better overall in terms of DNA yield and quality,which was primarily due to the poorer performance of the commercial binding buffer in recovering aDNA. | Ming Zhang Peng Cao Qing-Yan Dai Yong-Qiang Wang Xiao-Tian Feng Hong-Ru Wang Hong Wu Albert Min-Shan Ko Xiao-Wei Mao Yi-Chen Liu Li Yu Christian Roos Tilo Nadler Wen Xiao E.Andrew Bennett Qiao-Mei Fu | 2021 | Zoological Research2021，42，3： | 1 |
| 6 | Rapid and sensitive detection of avian influenza virus subtype H7 using NASBA显示文摘 | Richard A Collins Lung-Sang Ko King-Yip Fung Ka-Yun Chan Jun Xing Lok-Ting Lau Albert Cheung Hoi Yu | 2002 | Biochemical and Biophysical Research Communications2002，，： | 1 |
| 7 | Moir~ interferometry for dynamic frac- ture study显示文摘 | MATTHEW T KOKALYL JONGHEE LEE ALBERT S KO~AYASHI | 2003 | Optics and Lasers in Engineering2003，，40： | 1 |
| 8 | Topography-Aware Sensor Deployment Optimization with CMA-ES 显示文摘 | Vahab Akbarzadeh Albert Hung-Ren Ko Christian Gagne Marc Parizeau | 2011 | Lecture Notes in Computer Science2011，6239，： | 1 |
| 9 | Evaluation of Ordering Strategies for Constraint Satisfaction Reactive Scheduling 显示文摘 | Min Soo Suh Albert Lee Yung Jae Lee Young Kwan Ko | 1998 | Decision Support Systems1998，，22： | 1 |
| 10 | Effect of a region-wide incorporation of an algorithm based on the 2012 international consensus guideline on the practice pattern for the management of pancreatic cystic neoplasms in an integrated health system显示文摘AIM To examine the practice pattern in Kaiser Permanente Southern California(KPSC), i.e., gastroenterology(GI)/surgery referrals and endoscopic ultrasound(EUS), for pancreatic cystic neoplasms(PCNs) after the regionwide dissemination of the PCN management algorithm.METHODS Retrospective review was performed; patients with PCN diagnosis given between April 2012 and April 2015(18 mo before and after the publication of the algorithm) in KPSC(integrated health system with 15 hospitals and 202 medical offices in Southern California) were identified.RESULTS2558(1157 pre-and 1401 post-algorithm) received a new diagnosis of PCN in the study period. There was no difference in the mean cyst size(pre-19.1 mm vs post-18.5 mm, P = 0.119). A smaller percentage of PCNs resulted in EUS after the implementation of the algorithm(pre-45.5% vs post-34.8%, P < 0.001). A smaller proportion of patients were referred for GI(pre-65.2% vs post-53.3%, P < 0.001) and surgery consultations(pre-24.8% vs post-16%, P < 0.001) for PCN after the implementation. There was no significant change in operations for PCNs. Cost of diagnostic care was reduced after the implementation by 24%, 18%, and 36% for EUS, GI, and surgery consultations, respectively, with total cost saving of 24%.CONCLUSION In the current healthcare climate, there is increased need to optimize resource utilization. Dissemination of an algorithm for PCN management in an integrated health system resulted in fewer EUS and GI/surgery referrals, likely by aiding the physicians ordering imaging studies in the decision making for the management of PCNs. This translated to cost saving of 24%, 18%, and 36% for EUS, GI, and surgical consultations, respectively, with total diagnostic cost saving of 24%. | Andrew Khoi Nguyen Agathon Girgis Timnit Tekeste Karen Chang Mopelola Adeyemo Armen Eskandari Emilio Alonso Priyanka Yaramada Charles Chaya Albert Ko Edmund Burke Isaiah Roggow Rebecca Butler Aniket Kawatkar Brian S Lim | 2018 | World Journal of Clinical Cases2018，6，13： | 0 |
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