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| 1 | 胸腰段脊柱骨折定量影像学显示文摘描述影响胸腰段脊柱不同类型骨折,以及指导脊柱骨折治疗的不同分类及关键影响因素。目前脊柱骨折分类以Denis三柱模型为基石,包括压缩性骨折、爆裂性骨折、屈曲牵张骨折和骨折伴脱位。骨折分类系统包括胸腰椎损伤分类和严重程度评分(Thoracolumbar Injury Classification and Severity Score,TLICS)系统和AO脊柱胸腰椎损伤分类和严重程度评分(AOSpine-TLICS)。正确分类需要定量成像方法,采用多个测量指标来评定其属于不同TLICS或AOSpine-TLICS类型。如果TLICS评分>4或者AOSpine-TLICS评分>5,则患者需要手术治疗。本文重点描述X线片、CT及MRI影像表现和测量参数,包括爆裂性骨折患者中椎体楔形变成角和压缩性骨折椎体高度丢失百分比、椎弓根间距和腰椎管狭窄程度以及一些严重骨折(如屈曲牵张骨折、骨折伴脱位)患者的椎体位移和棘突间距增加。通过图解和影像案例展现这些影像学特征和相关参数。 | Fernando Ruiz Santiago Pablo Tomas Munoz Elena Moya Sanchez Marta Revelles Paniza Alberto Martinez Martinez Antonio Luis Perez Abela | 2017 | 临床与病理杂志2017，37，4： | 7 |
| 2 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 3 | Tolerance profiles and immunosuppression显示文摘 | Alberto Sanchez‐Fueyo | 2013 | Liver Transpl2013，，2： | 1 |
| 4 | Analytical relationships for designing rectangular drip irrigation units显示文摘 | JUANA Luis Losada ALBERTO Rodriguez-Sinobas LEONOR Sanchez Raul | 2004 | Journal of Irrigation and Drainage Engineering2004，130，1： | 1 |
| 5 | Rectal ulcer as a comp- lication of Longo circular hemorrhoidopexy显示文摘 | Folgado Alberto S Oro I Sanchez P | 2009 | Rev Esp Enferm Dig2009，，： | 1 |
| 6 | Immigration Status and HIV-risk Related Behaviors among Female Sex Workers in South America显示文摘 | Christian T. Bautista Carlos Mosquera Margarita Serra Alberto Gianella Maria M. Avila Victor Laguna-Torres Jean K. Carr Silvia M. Montano José L. Sanchez | 2008 | AIDS and Behavior2008，，2： | 1 |
| 7 | Implementation of real - time adaptivedigital shaping for nuclear spectroscopy 显示文摘 | Alberto Regadio Sebastian Sanchez - Prieto ManuelPrieto | 2014 | NuclearInstruments and Methods in Physics Research A2014，735，： | 1 |
| 8 | Carbon nanotubes paste electrodes as new detectors for capillary electrophoresis显示文摘 | Manuel Chicharro Alberto Sanchez Esperanza Bermejo | 2005 | Anal Chim Acta2005，543，： | 1 |
| 9 | Autonomous indoor ultrasonic positioning system based on a low-cost conditioning circuit显示文摘 | Alberto Sanchez Angel de Castro Santiago Elvira Guillermo Glez-de-Rivera Javier Garrido | 2011 | Measurement2011，，3： | 1 |
| 10 | Variable-angle scanning fluorescence spectrometry for the simultaneous determination of three diuretic drugs显示文摘 | Francisco Garcia Sanchez Alberto Fernandez Gutierrez Carmen Cruces Blanco | 1995 | Analytica Chimica Acta1995，306，： | 1 |
| 11 | Rapid and sensitive anthrone-sulfuric acid assay in microplate format to quan- tify carbohydrate in biopharmaceutical products : Method develop- ment and validation显示文摘 | Alberto Leyva Anelis Quintana Meily Sanchez | 2008 | Biologicals2008，36，2： | 1 |
| 12 | Development and Test of an Experimental Apparatus to Study Thermal-Choking in Ideal Gases and Self-decomposition in Superheated N2O显示文摘 | Patrick Lemieux Alberto Fara Pablo Sanchez William Murray | 2015 | Journal of Energy and Power Engineering2015，9，1： | 0 |
| 13 | Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease:removing axonal debris显示文摘Objective:The dopaminergic nigrostriatal neurons(DA cells)in healthy people present a slow degeneration with aging,which produces cellular debris throughout life.About 2%-5%of people present rapid cell degeneration of more than 50%of DA cells,which produces Parkinson's disease(PD).Neuroinflammation accelerates the cell degeneration and may be critical for the transition between the slow physiological and the rapid pathological degeneration of DA cells,particularly when it activates microglial cells of the medial forebrain bundle near dopaminergic axons.As synaptic debris produced by DA cell degeneration may trigger the parkinsonian neuroinflammation,this study investigated the removal of axonal debris produced by retrograde degeneration of DA cells,paying particular attention to the relative roles of astrocytes and microglia.Methods:Rats and mice were injected in the lateral ventricles with 6-hydroxydopamine,inducing a degeneration of dopaminergic synapses in the striatum which was not accompanied by non-selective tissue damage,microgliosis or neuroinflammation.The possible retrograde degeneration of dopaminergic axons,and the production and metabolization of DA-cell debris were studied with immunohistochemical methods and analyzed in confocal and electron microscopy images.Results:The selective degeneration of dopaminergic synapses in the striatum was followed by a retrograde degeneration of dopaminergic axons whose debris was found within spheroids of the medial forebrain bundle.These spheroids retained mitochondria and most(e.g.,tyrosine hydroxylase,the dopamine transporter protein,and amyloid precursor protein)but not all(e.g.,α-synuclein)proteins of the degenerating dopaminergic axons.Spheroids showed initial(autophagosomes)but not late(lysosomes)components of autophagy(incomplete autophagy).These spheroids were penetrated by astrocytic processes of the medial forebrain bundle,which provided the lysosomes needed to continue the degradation of dopaminergic debris.Finally,dopaminergic proteins were observed in the cell somata of astrocytes.No microgliosis or microglial phagocytosis of debris was observed in the medial forebrain bundle during the retrograde degeneration of dopaminergic axons.Conclusions:The present data suggest a physiological role of astrocytic phagocytosis of axonal debris for the medial forebrain bundle astrocytes,which may prevent the activation of microglia and the spread of retrograde axonal degeneration in PD. | Ingrid Morales Ricardo Puertas-Avendaño Alberto Sanchez Adrian Perez-Barreto Clara Rodriguez-Sabate Manuel Rodriguez | 2021 | Translational Neurodegeneration2021，10，4： | 0 |
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