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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:对阿尔茨海默病诊断指南的推荐和介绍显示文摘背景:尽管早在1984年就制定了阿尔茨海默病(AD)的临床诊断标准,但是近年来的研究进展从未被补充到诊断标准中。因此,制定一个新的临床诊断标准已经成为大家的共识。方法:在2009年,美国国立老化研究所与AD协会组织了一系列圆桌会议,目的是讨论用于AD临床和科研的诊断标准的修订路线。经讨论后决定组建3个独立的工作组,分别制定AD在3个不同疾病发展阶段的诊断标准,即痴呆阶段、有症状的痴呆前期、无症状的临床前期。结果:修订版AD诊断标准与1984年版诊断标准有两处显著的差别:加入了能提示潜在疾病状态的生物标志物的内容;制定了不同认知障碍阶段的诊断标准。其中,3个工作组一致认为,生物标志物的诊断价值还需要更多研究来规范和验证。另外,修订版中还明确区分了仅存在AD病理生理改变(语义性)和仅存在AD临床表现(概念性)两种诊断的差别,该内容在1984年版中没有体现。结论:修订版AD诊断标准中共产生了3个文件,其中,核心的关于AD的痴呆阶段诊断标准和可归于AD的MCI阶段标准推荐用于临床诊断,而临床前期诊断标准仅推荐用于研究使用。 | Jack CR Jr Albert MS Knopman DS McKhann GM Sperling RA Carrillo MC Thies B Phelps CH 贾建平(译) 李丹(译) 閵芳菊(译) 陆璐(译) 张逸驰(译) 黄丽(译) | 2012 | 中华神经科杂志2012，45，5： | 26 |
| 2 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 3 | An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol显示文摘The poor gas selectivity problem has been a long-standing issue for miniaturized chemical-resistor gas sensors.The electronic nose(e-nose)was proposed in the 1980s to tackle the selectivity issue,but it required top-down chemical functionalization processes to deposit multiple functional materials.Here,we report a novel gas-sensing scheme using a single graphene field-effect transistor(GFET)and machine learning to realize gas selectivity under particular conditions by combining the unique properties of the GFET and e-nose concept.Instead of using multiple functional materials,the gas-sensing conductivity profiles of a GFET are recorded and decoupled into four distinctive physical properties and projected onto a feature space as 4D output vectors and classified to differentiated target gases by using machine-learning analyses.Our single-GFET approach coupled with trained pattern recognition algorithms was able to classify water,methanol,and ethanol vapors with high accuracy quantitatively when they were tested individually.Furthermore,the gas-sensing patterns of methanol were qualitatively distinguished from those of water vapor in a binary mixture condition,suggesting that the proposed scheme is capable of differentiating a gas from the realistic scenario of an ambient environment with background humidity.As such,this work offers a new class of gas-sensing schemes using a single GFET without multiple functional materials toward miniaturized e-noses. | Takeshi Hayasaka Albert Lin Vernalyn C.Copa Lorenzo P.Lopez Jr Regine A.Loberternos Laureen Ida M.Ballesteros Yoshihiro Kubota Yumeng Liu Arnel A.Salvador Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 4 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 5 | An exact, closed-form solution for equilibrium of trveling, sagged, elastic cables under uniformly distributed loading显示文摘The exact, closed-form solution for equilibrium of traveling, sagged, elastic cables uniformly-distributed loading is derived. Three components of displacement describing two equilibria of an extensible, traveling, elastic cable are also obtained. Illustrations of equilibrium configuration, tension distribution and displacements of cables are given. | Albert C. LUO and.C.DMOTE,Jr Department of Mechanical and Industrial Engineering, Southern Illinois University Edwardsville, Edwardsville, IL 62034-1805, USA e-mall:aluo @siue.edu Office of the President, Main Administration. Building, University of Ma | 2000 | Communications in Nonlinear Science and Numerical Simulation2000，5，1： | 2 |
| 6 | Guidelines for the early management of adults with ischemic stroke:a guideline from the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups:The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists显示文摘 | Adams HP Jr Del ZG Alberts M J | 2007 | Circulation2007，115，： | 1 |
| 7 | Guidelines for the early management of adults with ischemic stroke : a guideline from the American Heart Association/American Stroke Association Stroke Coun- cil, Clinical Cardiology Council, Cardiovascular Radiology and Inter- vention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists 显示文摘 | Adams H P Jr del-Zoppo G Alberts M J | 2007 | Stroke2007，38，5： | 1 |
| 8 | Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema 显示文摘 | Mason JO 3rd Albert MA Jr Vail R | 2006 | Retina2006，26，3： | 1 |
| 9 | Social Capital and Knowledge Creation: Diminishing Returns of the Number and Strength of Exchange Relationships 显示文摘 | M Ann Mcfadyen Albert A Cannella JR | 2004 | Academy of Manage- ment Journal2004，，5： | 1 |
| 10 | Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus显示文摘 | A. Bourreille A. Ignjatovic L. Aabakken E. Loftus Jr R. Eliakim M. Pennazio Y. Bouhnik E. Seidman M. Keuchel J. Albert S. Ardizzone S. Bar-Meir R. Bisschops E. Despott P. Fortun R. Heuschkel J. Kammermeier J. Leighton G. Mantzaris D. Moussata S. Lo V. Pau | 2009 | Endoscopy2009，，07： | 1 |
| 11 | Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia显示文摘 | Albert KA Hemmings HC Jr Adamo AI | 2002 | Arch Gen Psychiatry2002，59，8： | 1 |
| 12 | Guidelines for the early management of adults with ischemic stroke显示文摘 | Adams HP Jr del Zoppo G Alberts MJ | 2007 | Stroke2007，38，5： | 1 |
| 13 | The supratentorial artery显示文摘 | Albert L Rhoton JR | 2002 | Neurosurgery2002，，： | 1 |
| 14 | Guidelines for the early management of adults with ischemic stroke 显示文摘 | Adams HP JR Del Zoppo G Alberts M J | 2007 | Stroke2007，38，5： | 1 |
| 15 | Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease显示文摘 | Jack CR Jr Albert MS Knopman DS | 2011 | Alzheimers Dement2011，7，3： | 1 |
| 16 | Guide- lines for the early management of adults with ischemic stroke: a guideline from the American Heart Association / American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Inter- vention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Re- search Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guide- line as an educational tool for neurologists显示文摘 | Adams HP Jr del Zoppo G Alberts M J | 2007 | Circula-tion2007，115，20： | 1 |
| 17 | Guidelines for the early management of adults with ischemic stroke:a guideline from the American Heart Association/American Stroke Association Stroke Council,Clinical Cardiology Council,Cardiovascular Radiology and Intervention Council,and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups:the American Academy of Neurology affims the value of this guideline as an educational tool for neurologists显示文摘 | Adams HP Jr del Zoppo G Alberts MJ | 2007 | J Stroke2007，38，5： | 1 |
| 18 | Guidelines for the early management of adults with ischemic stroke : a guide- line from the American Heart Association/American Stroke &ssoeiation Stroke Council, Clinical Cardiology Council, Car diovascular Radiology and Intervention Council, and the Ath- erosclerotie Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups 显示文摘 | Adams HP Jr del Zoppo G Alberts MJ | 2007 | Stroke2007，38，： | 1 |
| 19 | The impor-tance of leukotrienes in airway inflammation in a mousemodel of asthma显示文摘 | Henderson WR Jr Lewis DB Albert RK | 1996 | J Exp Med1996，184，4： | 1 |
| 20 | Brand Community 显示文摘 | Muniz Albert M Jr Thomas C O' Guinn | 2001 | Journal of Consumer Research2001，27，3： | 1 |
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