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您的检索式：作者名="Alex F.Chen"
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| 1 | 一氧化氮合酶基因治疗在心血管疾病中的应用显示文摘 | Alex F.Chen 缪朝玉 | 2002 | 中华心血管病杂志2002，30，2： | 4 |
| 2 | Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis显示文摘Ischemic heart diseases(IHDs)cause great morbidity and mortality worldwide,necessitating effective treatment.Salvianic acid A sodium(SAAS)is an active compound derived from the well-known herbal medicine Danshen,which has been widely used for clinical treatment of cardiovascular diseases in China.This study aimed to confirm the cardioprotective effects of SAAS in rats with myocardial infarction and to investigate the underlying molecular mechanisms based on proteome and transcriptome profiling of myocardial tissue.The results showed that SAAS effectively protected against myocardial injury and improved cardiac function.The differentially expressed proteins and genes included important structural molecules,receptors,transcription factors,and cofactors.Functional enrichment analysis indicated that SAAS participated in the regulation of actin cytoskeleton,phagosome,focal adhesion,tight junction,apoptosis,MAPK signaling,and Wnt signaling pathways,which are closely related to cardiovascular diseases.SAAS may exert its cardioprotective effect by targeting multiple pathways at both the proteome and transcriptome levels.This study has provided not only new insights into the pathogenesis of myocardial infarction but also a road map of the cardioprotective molecular mechanisms of SAAS,which may provide pharmacological evidence to aid in its clinical application. | Dan Jia Cheng-zhong Zhang Yan Qiu Xiao-fei Chen Lin Jia Alex F.Chen Yi-feng Chai Zhen-yu Zhu Jin Huang Chuan Zhang | 2019 | Acta Pharmacologica Sinica2019，40，12： | 4 |
| 3 | MicroRNA regulation of endothelial progenitor cell angiogenesis in diabetes显示文摘Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabetes that correlates inversely with its mortality rate.In addition,EPC angiogenic functions are severely impaired in diabetes.However,the molecular and cellular mechanisms underlying EPC dysfunction are poorly understood.Our current studies have focused on in vitro and in | Alex F.Chen | 2010 | 中国病理生理杂志2010，26，A10： | 1 |
| 4 | Low-dose nifedipine rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice显示文摘It is of great clinical significance to develop potential novel strategies to prevent diabetic cardiovascular complications.Endothelial progenitor cell(EPC)dysfunction is a key contributor to diabetic vascular complications.In the present study we evaluated whether low-dose nifedipine could rescue impaired EPC-mediated angiogenesis and prevent cardiovascular complications in diabetic mice.Diabetes was induced in mice by five consecutive injections of streptozotocin(STZ,60 mg·kg−1·d−1,i.p.).Diabetic mice were treated with low-dose nifedipine(1.5 mg·kg−1·d−1,i.g.)for six weeks.Then,circulating EPCs in the peripheral blood were quantified,and bone marrow-derived EPCs(BM-EPCs)were prepared.We showed that administration of low-dose nifedipine significantly increased circulating EPCs,improved BM-EPCs function,promoted angiogenesis,and reduced the cerebral ischemic injury in diabetic mice.Furthermore,we found that low-dose nifedipine significantly increased endothelial nitric oxide synthase(eNOS)expression and intracellular NO levels,and decreased the levels of intracellular O2.−and thrombospondin-1/2(TSP-1/2,a potent angiogenesis inhibitor)in BM-EPCs of diabetic mice.In cultured BM-EPCs,co-treatment with nifedipine(0.1,1μM)dose-dependently protected against high-glucose-induced impairment of migration,and suppressed high-glucose-induced TSP-1 secretion and superoxide overproduction.In mice with middle cerebral artery occlusion,intravenous injection of diabetic BM-EPCs treated with nifedipine displayed a greater ability to promote local angiogenesis and reduce cerebral ischemic injury compared to injection of diabetic BM-EPCs treated with vehicle,and the donor-derived BM-EPCs homed to the recipient ischemic brain.In conclusion,low-dose nifedipine can enhance EPCs’angiogenic potential and protect against cerebral ischemic injury in diabetic mice.It is implied that chronic treatment with low-dose nifedipine may be a safe and economic manner to prevent ischemic diseases(including stroke)in diabetes. | Cheng Peng Lijun Yang Chuan Zhang Yu Jiang Liu-wen-xin Shang Jia-bei He Zhen-wei Zhou Xia Tao Lu Tie Alex F.Chen He-hui Xie | 2023 | Acta Pharmacologica Sinica2023，44，1： | 0 |
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