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| 1 | Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment显示文摘AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment.METHODS: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 months.RESULTS: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were studied.Lamivudine was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug cessation.Genotype B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) groups.CONCLUSION: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype. | Henry Lik-Yuen Chan May-Ling Wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse Lawrence Cheung-Tsui Hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2003 | World Journal of Gastroenterology2003，9，12： | 21 |
| 2 | Imaging of the anterior cruciate ligament显示文摘The anterior cruciate ligament(ACL)is an important structure in maintaining the normal biomechanics of the knee and is the most commonly injured knee ligament.However,the oblique course of the ACL within the intercondylar fossa limits the visualization and assessment of the pathology of the ligament.This pictorial essay provides a comprehensive and illustrative review of the anatomy and biomechanics as well as updated information on different modalities of radiological investigation of ACL,particularly magnetic resonance imaging. | Wing Hung Alex Ng James Francis Griffith Esther Hiu Yee Hung Bhawan Paunipagar Billy Kan Yip Law Patrick Shu Hang Yung | 2011 | World Journal of Orthopedics2011，2，8： | 4 |
| 3 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 4 | XP11.2 Translocation renal cell carcinoma: Clinical experience of Taipei Veterans General Hospital显示文摘 | Chia-Chen Hung Chin-Chen Pan Chih-Chieh Lin Alex T.L. Lin Kuang-Kuo Chen Yen-Hwa Chang | 2011 | Journal of the Chinese Medical Association2011，，11： | 1 |
| 5 | Surrogate End Points and Long-Term Outcome in Patients With Chronic Hepatitis B显示文摘 | Vincent Wai–Sun Wong Grace Lai–Hung Wong Angel Mei–Ling Chim Paul Cheung–Lung Choi Anthony Wing–Hung Chan Steven Woon–Choy Tsang Alex Yui Hui Hoi–Yun Chan Joseph Jao–Yiu Sung Henry Lik–Yuen Chan | 2009 | Clinical Gastroenterology and Hepatology2009，，10： | 1 |
| 6 | Dietary lecithin improves feed efficiency without impacting meat quality in immunocastrated male pigs and gilts fed a summer ration containing added fat显示文摘The aim of this study was to investigate the effects of sex and dietary lecithin on growth performance,meat quality, muscle collagen content and gene expression of key genes involved in collagen synthesis in finisher pigs.A total of 256 pigs(Large White × Landrace) were allotted to a 2 × 2 factorial arrangement involving sex(gilt or immunocastrated [IC] male) and dietary treatment(0 or 5 g/kg of dietary lecithin).All diets were formulated to contain 4.6% tallow with relatively high total fat of 6.3%.After 5 weeks of dietary treatment, pigs were slaughtered and Longissimus dorsi muscle was obtained for evaluation of meat quality and collagen content.Rectus abdominis muscle was analysed for gene expression of key genes involved in collagen synthesis namely, type Ⅰ(a1) procollagen(COL1A1), type Ⅲ(a1) procollagen(COL3A1), a-subunit of prolyl 4-hydroxylase(P4H), lysyl oxidase and metalloproteinase-1(MMP-1).The results showed that lecithin improved feed efficiency of all pigs(P < 0.05) but it had no effect on feed intake, average daily gain and dressing percentage(P > 0.05).Lecithin also had no effect on meat compression, shear force, collagen content and gene expression(P > 0.05).Immunocastrated male had higher growth rate and increased COL1 A1 expression than gilts.However, sex had no effect on fat depth at the P2 site(65 mm from the midline over the last rib), collagen content and expression of other genes(P > 0.05).In conclusion, lecithin improved feed efficiency in finishing pigs without impacting pork quality.Thus, inclusion of lecithin in diets containing high amount of tallow during the summer period could be beneficial. | Henny Akit Cherie Collins Fahri Fahri Alex Hung Darryl D'Souza Brian Leury Frank Dunshea | 2018 | Animal Nutrition2018，，2： | 1 |
| 7 | Metabolic and Adipokine Profile of Chinese Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Vincent Wai–Sun Wong Alex Yui Hui Steven Woon–Choy Tsang Joyce Lai–Yee Chan Ada Mei–Ling Tse Kui–Fat Chan Wing–Yee So Angela Yuen–Shan Cheng Wing–Fung Ng Grace Lai–Hung Wong Joseph Jao–Yiu Sung Henry Lik–Yuen Chan | 2006 | Clinical Gastroenterology and Hepatology2006，，9： | 1 |
| 8 | Weakly-and Semisupervised Probabilistic Segmentation and Quantification of Reverberation Artifacts显示文摘Objective and Impact Statement.We propose a weakly-and semisupervised,probabilistic needle-and-reverberation-artifact segmentation algorithm to separate the desired tissue-based pixel values from the superimposed artifacts.Our method models the intensity decay of artifact intensities and is designed to minimize the human labeling error.Introduction.Ultrasound image quality has continually been improving.However,when needles or other metallic objects are operating inside the tissue,the resulting reverberation artifacts can severely corrupt the surrounding image quality.Such effects are challenging for existing computer vision algorithms for medical image analysis.Needle reverberation artifacts can be hard to identify at times and affect various pixel values to different degrees.The boundaries of such artifacts are ambiguous,leading to disagreement among human experts labeling the artifacts.Methods.Our learning-based framework consists of three parts.The first part is a probabilistic segmentation network to generate the soft labels based on the human labels.These soft labels are input into the second part which is the transform function,where the training labels for the third part are generated.The third part outputs the final masks which quantifies the reverberation artifacts.Results.We demonstrate the applicability of the approach and compare it against other segmentation algorithms.Our method is capable of both differentiating between the reverberations from artifact-free patches and modeling the intensity fall-off in the artifacts.Conclusion.Our method matches state-of-the-art artifact segmentation performance and sets a new standard in estimating the per-pixel contributions of artifact vs underlying anatomy,especially in the immediately adjacent regions between reverberation lines.Our algorithm is also able to improve the performance of downstream image analysis algorithms. | Alex Ling Yu Hung Edward Chen John Galeotti | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 9 | 对某一水下航行器集成式周期变距螺旋桨的试验研究(英文)显示文摘A series of experimental studies of the innovative propulsor named Collective and Cyclic Pitch Propeller(CCPP) applied to an underwater vehicle were designed and performed at the Australian Maritime College, University of Tasmania. The bollard pull and captive model tests were conducted to investigate the characteristics of CCPP and to examine the effect of different parameter settings to its performance. The results show that the CCPP is able to generate effective manoeuvring forces in various operational condition. In addition, the obtained results in the form of force coefficients provide a useful empirical model for the simulation and control of an underwater vehicle equipped with this propulsor. | Minh Tran Jonathan Binns Shuhong Chai Alex Forrest Hung Nguyen | 2018 | Journal of Marine Science and Application2018，17，4： | 0 |
| 10 | 中国香港地区老年痴呆患者的口腔健康状况显示文摘目的:比较中国香港地区痴呆患者组和健康对照组之间.刷牙习惯、静息状态下唾液流率以及口腔健康状况是否存在不同。材料和方法:经过样本量计算.需要纳入82位60岁以上的中国老年痴呆患者.能够配合牙周探诊操作并且加入日常管理中心。年龄、性别匹配全身健康的非痴呆老年人作为对照组。用调查问卷收集刷牙情况。此外.测量静息状态下的唾液流率.用龋失补指数DMFT指数和社区牙周指数(CPI)分别记录患龋情况和牙周状况。结果:招募了59名老年痴呆患者作为痴呆组.以及相同数目年龄、性别匹配的健康老年人作为对照组。他们的平均年龄为80岁(SD=7)。相对于对照组,老年痴呆患者较少每天刷牙两次(31%VS5%:P〈0.0001)。再者.唾液流率也较对照组低(0.30ml/m.nVS0.41m1/min:P=0.043)。龋患病率平均DMFT值(±SD)与对照组相似(223±8.2vs21.5±82.P=0.59)。牙周袋(CPI〉3)的患病率在两组中没有差异(78%vs74%.P=0.64)。结论:相较于对照组,较少的老年痴呆患者会每天刷牙两次。尽管他们静息状态下唾液分泌量减少.他们的龋发病率和重度牙周病的患病率与对照组相比没有统计学意义上的差异。 | Chun Hung Chu Alice Ng Alex M1.H. Chau Eeward C. M.Lo 池莉(译) 滕伟(审) | 2018 | 中国口腔医学继续教育杂志2018，21，4： | 0 |
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