|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Role of the endothelium in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokines,is a hallmark of active gut disease and is closely related to disease severity.The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines,growth factors,and adhesion molecules,altering coagulant capacity,barrier function and blood cell recruitment in injury.This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions. | Walter E Cromer J Michael Mathis Daniel N Granger Ganta V Chaitanya J Steven Alexander | 2011 | World Journal of Gastroenterology2011，17，5： | 10 |
| 3 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 4 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 5 | Influence of the form of photodeposited platinum on titania upon its photocatalytic activity in CO and acetone oxidation显示文摘 | Alexander V V Evgueni N S Jin Z S | 1999 | Journal of Photochemistry and Photobiology A:Chemistry1999，125，： | 1 |
| 6 | A facile synthesis of annulated thiatriazine dioxides 显示文摘 | Alexander N K Alexander N S Svetlana V S | 2010 | Journal of Synthetic Organic Chemistry2010，，1： | 1 |
| 7 | Application of Magic-Angle Spinning NMR to Examine the Nature of Protons in Titanate Nanotubes显示文摘 | Bavykin Dmitry V Carravetta Marina Kulak Alexander N | 2010 | Chemistry of Materials2010，22，8： | 1 |
| 8 | Climate ex- tremes: progress and future directions显示文摘 | Alexander L V Tapper N Zhang X eta | 2009 | International Journal of Climatology2009，29，3： | 1 |
| 9 | Seasonal variability of stable carbon and nitrogen isotope ratios of organ- ism in a North Pacific Bay 显示文摘 | GOERING J ALEXANDER V HAUBENSTOCK N | 1990 | Estuar Coast Shelf Sci1990，30，： | 1 |
| 10 | Vibrofluidized-and fixed-bed photocatalytic reactors:case of gaseous acetone photooxidation显示文摘 | Alexander V Vorontsov Evgueni N Savinov Panagiotis G Smirniotis | 2000 | Chem Eng Sci2000，55，： | 1 |
| 11 | Characterization of Cerevral Hemodynamic Phase Following Severe Head Trauma:Hypoperfusion,Hyperemia,and Vasospasm显示文摘 | Martin N A Patwardhan R V Alexander M | 1997 | J lbursurg1997，87，： | 1 |
| 12 | 查看详情显示文摘 | Alexander H K Balatsky V Nagaosa N | | 0，，： | 1 |
| 13 | An antisense inhibitor of apolipoprotein C-Ⅲ lowers fasting plasma apolipoprotein C- In and triglyceride concentrations in healthy volunteers 显示文摘 | Alexander V Novak T Viney N | 2012 | J Am Coll Cardiol2012，59，131： | 1 |
| 14 | 显示文摘 | Alexander V V Evgueni N S Jin Z S | 1999 | J Photochem Photo biolA1999，125，： | 1 |
| 15 | Concerning biological equivalent of radiation of light emitting diode and lamp light sources with correlated color temperature from 1800K up to 10000K显示文摘 | ANDREI V A ALEXANDER L Z MIKHAIL N M | 2012 | Light & Engineering2012，20，3： | 1 |
| 16 | Concerning biological equivalent of radiation of light-emiting diode and lamp light sources with correla- ted colour temperature from 1800K up to 10000K 显示文摘 | Andrei V Aladov Alexander L Zakgeim Mikhail N Mize- roy | 2012 | Light & Engineering2012，20，3： | 1 |
| 17 | Characterization of cerebral hemodynamic phases following severe head trauma: hypoperfusion, hyperemia and vasospasm 显示文摘 | MARTIN N A PATWARDHAM P V ALEXANDER M J | 1997 | J Neurosurg1997，87，1： | 1 |
| 18 | Prevention of the selection of resistant staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model:andditive effect of the combination显示文摘 | ALEXANDER A F SERGEY N V IRENE Y L | 2004 | International Journal of Antimicrobial Agents2004，23，： | 1 |
| 19 | Optical Properties of Cadmium SuLfide Colloidal Dispersions Prepared by Interphase Synthesis 显示文摘 | Alexander N K Svetlana A V Anatoly I L | 2008 | OpticalMatedals2008，30，8： | 1 |
| 20 | Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias显示文摘 | Alexander V P | 2004 | progress in biophysics & molecular biology2004，85，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员