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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，： | 1 |
| 3 | Effect of aging of chemicals in soil on their biodegradability and extractability 显示文摘 | Hatzinger P B Alexander M | 1995 | Environ Sci Techno11995，29，2： | 1 |
| 4 | Crystal structure of the human TβR2 ectodom-TGF-β3 complex显示文摘 | P John Hart Shas hank deep Alexander B | 2002 | Nat Struct Biol2002，9，3： | 1 |
| 5 | Volatilisation processes in wastewater treatment plants as a source of potential exposure to VOCs显示文摘 | ALEXANDER P B MARK S V | 1997 | Pergamon1997，21，： | 1 |
| 6 | Molecular epi-demiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P Jr | | 0，，： | 1 |
| 7 | Biodegradation of organic compounds sequestered in organic solids or in nanopores within silica particles 显示文摘 | Hatzinger P B Alexander M A | 1997 | Environ Toxicol Chem1997，16，11： | 1 |
| 8 | Reflec- tance technique for predicting soil organic matter显示文摘 | Krishnan P Alexander JD Butler B J Hummel JW | 1980 | Soil Science Society of America Journal1980，44，6： | 1 |
| 9 | Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarctionundergoing an invasive strategy according to hemoglobin levels显示文摘 | Hanna E B Alexander K P Chen A Y | 2013 | Am J Cardiol2013，111，8： | 1 |
| 10 | SPARTACAS:Automating components reuse and adaptation显示文摘 | Morel B Alexander P | 2004 | IEEE Transactions on Software Engineering2004，30，9： | 1 |
| 11 | Genotypic variations in the accumulation of Cd, Cu, Pb and Zn exhibited by six commonly grown vegetable 显示文摘 | Alexander P D Alloway B J Dourado A M | 2006 | Environ Pollut2006，144，3： | 1 |
| 12 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998 显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，12： | 1 |
| 13 | Flow-injection potentiometric determination of free cadmium ions with a cadmium ion-selective electrode显示文摘 | TROJANOWICZ M ALEXANDER W P HIBBERT D B | 1998 | Analytica Chimica Acta1998，370，23： | 1 |
| 14 | Molecu lar epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998 显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，12： | 1 |
| 15 | Internal stresses and the martensite start temperature in alumina-zirconia composites: effects of composition and microstructure显示文摘 | ALEXANDER K B BECHER P F WANG X | 1995 | J Am Ceram Soc1995，78，1： | 1 |
| 16 | Biodegradation of organic compounds sequestered in organic solids or in nanopores within silica partieles显示文摘 | Hatzinger P B Alexander M | 1997 | Environ Toxieol Chem1997，16，： | 1 |
| 17 | NCEP-defined metabolic syndrome, diabetes, and prevalence ofcoronary heart disease among NHANES III participants age50 years and older显示文摘 | Alexander C M Landsman P B’Teutsch S M | 2003 | Diabetes2003，52，5： | 1 |
| 18 | Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy显示文摘 | Eyk AS Alexei B J Alexander P | 2003 | Neoplasia2003，5，3： | 1 |
| 19 | Genotypic variations in the accumulation of Cd, Cu, Pb and Zn exhibited by six commonly grown vegetables显示文摘 | Alexander P D Alloway B J Dourado A M | 2006 | Environmental Pollution2006，144，： | 1 |
| 20 | Pentamethylnaphalenes and ralted compounds in sedimentary organic matter显示文摘 | Bastow T P Alexander R Sosrowidjojo I B | 1998 | Organic geochemistry1998，28，： | 1 |
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