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| 1 | 溃疡性结肠炎显示文摘溃疡性结肠炎(ulcerativecolitis,uc)是一种消化道炎症性疾病,病变主要位于结直肠。UC好发于青年人,发达国家的人群患病率较高。UC表现为结直肠弥漫性、连续性浅表炎症,以及相应的组织学改变。下消化道内镜或影像检查可以明确诊断。目前尚未发现UC的明确病因,其发病机制与遗传易感个体的结肠内环境变化有关,具有慢性、终身、易复发的病程特点。 | Alexander C Ford Paul Moayyedl Steven B Hanauer Joseph B Kirsner 谭蓓 吴东 | 2017 | 英国医学杂志中文版2017，20，7： | 7 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Pancreatic Cancer Surgery in the New Millennium: Better Prediction of Outcome显示文摘 | Werner Hartwig Thilo Hackert Ulf Hinz Alexander Gluth Frank Bergmann Oliver Strobel Markus W. Büchler Jens Werner | 2011 | Annals of Surgery2011，，2： | 5 |
| 4 | A new rat model of portal hypertension induced by intraportal injection of microspheres显示文摘AnewratmodelofportalhypertensioninducedbyintraportalinjectionofmicrospheresLIXiangNong1,ISBenjamin2andBAlexander2Subjecthead... | LI Xiang-Nong IS Benjamin B Alexander | 1998 | World Journal of Gastroenterology1998，4，1： | 4 |
| 5 | 成人突发性耳聋突发性耳聋:是否采用高压氧疗法需要达成共识显示文摘突发性耳聋的自愈率只有39%,其患者需要接受相应的治疗1.Fishman和Cullen所著的突发性耳聋治疗方法的文章中未提及高压氧治疗2。Cochrane系统评价发现高压氧疗法与类固醇疗法相比,疗效更为显著。Cochrane系统评价指出,“由于采用此疗法的患者人数较少,高压氧疗法尚不成熟完善,且相关的文献报道较少,应对其疗效的可靠性持怀疑态度。” | J Alexander Ahmed B Bayoumy 李谨(译) 张罗(校) | 2019 | 英国医学杂志中文版2019，22，5： | 4 |
| 6 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 7 | EGF promotes mammalian cell growth by suppressing cellular senescence显示文摘 | Peter B Alexander Lifeng Yuan Pengyuan Yang Tao Sun Rui Chen Handan Xiang Jiekai Chen Haoyu Wu Daniel R Radiloff Xiao-Fan Wang | 2015 | Cell Research2015，25，1： | 3 |
| 8 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 9 | Overvoltage control during restoration显示文摘 | Adibi M M Alexander R W Avramovic B | 1992 | IEEE Trans on Power Systems1992，7，4： | 2 |
| 10 | Risk factors associated with major cerebrovascular complications after intracranial stenting显示文摘 | F Nahab M J. Lynn S E. Kasner M J. Alexander R Klucznik O O. Zaidat J Chaloupka H Lutsep S Barnwell M Mawad B Lane M I. Chimowitz | 2009 | Neurology2009，，23： | 2 |
| 11 | 未来阻燃剂的设计(英文)显示文摘阻燃剂已经存在数千年了,但最近200年才发展出一些新化学结构的阻燃剂。目前使用的阻燃剂主要包括7种类型,它们是卤素基、磷基、膨胀体系、矿物填料、氮基、无机物基、高分子纳米复合体系等。现在,阻燃剂的使用仅仅专注于提供消防,也没有考虑如何延长它们的使用寿命,没有考虑如何处理阻燃剂使用结束后的后处理问题。随着将来对环境保护新要求的提升,以及新型起火原因的出现,现有的几类阻燃剂显然是不够的,必须努力开发新型阻燃剂,例如硅基阻燃剂、过度金属催化作用阻燃剂等。讨论了未来阻燃剂的设计必须考虑的环境保护和新的起火原因等问题,以及与未来新型阻燃剂有关的潜在化学问题。最后提出了在新型阻燃剂研究过程中,减少环境污染、保持防火安全的原则。 | Alexander B Morgan | 2013 | 中国材料进展2013，32，3： | 2 |
| 12 | Overvoltage control during restoration显示文摘 | Adibi M M Alexander R W Avramovic B | 1992 | IEEE Transactions on Power Systems1992，7，4： | 2 |
| 13 | Serum malondialdehyde and prevalent cardiovascular disease in disease in hemodialysis显示文摘 | Mona B Zipora M Alexander B | 1999 | Kidney Int1999，56，： | 2 |
| 14 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 15 | Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infracted swine myocardium显示文摘 | Mickey S Amir B | 1993 | J Am Coll Cardiol1993，22，7： | 1 |
| 16 | Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome显示文摘 | Alexander R B Ponniah S Hasday J HebelJR | 1998 | Urology1998，52，： | 1 |
| 17 | Dissolved nitrogen uptake by a cyanobacterial bloom (Anabaena flosaquae) in a subarctic lake 显示文摘 | Gu B H Alexander V | 1993 | Applied and Environmental Microbiology1993，59，2： | 1 |
| 18 | Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998显示文摘 | Brown B A Oberste M S Alexander J P | 1999 | J Virol1999，73，： | 1 |
| 19 | Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene,encoding a second cytochrome P-450 involved in ergosterol biosynthesis显示文摘 | Skaggs B A Alexander J F | 1996 | Gene1996，169，1： | 1 |
| 20 | High Near-infrared Reflectivity Modulation with Polycrystalline Electrochromic WO3 Films显示文摘 | GOLDNER R B MENDELSOHN D H ALEXANDER J | 1983 | Appl Phy Lett1983，43，12： | 1 |
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