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您的检索式：作者名="Alexander Vidal"
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| 1 | Anti-inflammatory properties of the short-chain fatty acids acetate and propionate:A study with relevance to inflammatory bowel disease显示文摘AIM: To compare the anti-inflammatory properties of butyrate with two other SCFAs,namely acetate and propionate,which have less well-documented effects on inflammation. METHODS: The effect of SCFAs on cytokine release from human neutrophils was studied with ELISA. SCFA-dependent modulation of NF-κB reporter activity was assessed in the human colon adenocarcinoma cell line,Colo320DM. Finally,the effect of SCFAs on gene expression and cytokine release,measured with RT-PCR and ELISA,respectively,was studied in mouse colon organ cultures established from colitic mice. RESULTS: Acetate,propionate and butyrate at 30 mmol/L decreased LPS-stimulated TNFα release from neutrophils,without affecting IL-8 protein release. All SCFAs dose dependently inhibited NF-κB reporter activity in Colo320DM cells. Propionate dose-dependently suppressed IL-6 mRNA and protein release from colon organ cultures and comparative studies revealed that propionate and butyrate at 30 mmol/L caused a strong inhibition of immune-related gene expression,whereas acetate was less effective. A similar inhibition was achieved with the proteasome inhibitor MG-132,but not the p38 MAPK inhibitor SB203580. All SCFAs decreased IL-6 protein release from organ cultures. CONCLUSION: In the present study propionate and butyrate were equipotent,whereas acetate was less effective,at suppressing NF-κB reporter activity,immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate,in addition to butyrate,could be useful in the treatment of inflammatory disorders,including IBD. | Sofia Tedelind Fredrik Westberg Martin Kjerrulf Alexander Vidal | 2007 | World Journal of Gastroenterology2007，13，20： | 81 |
| 2 | Experimental control of optical helicity in nanophotonics显示文摘An analysis of light–matter interactions based on symmetries can provide valuable insight,particularly because it reveals which quantities are conserved and which ones can be transformed within a physical system.In this context,helicity can be a useful addition to more commonly considered observables such as angular momentum.The question arises how to treat helicity,the projection of the total angular momentum onto the linear momentum direction,in practical experiments.In this paper,we put forward a simple but versatile experimental treatment of helicity.We then apply the proposed method to the scattering of light by isolated cylindrical nanoapertures in a gold film.This allows us to study the helicity transformation taking place during the interaction of focused light with the nanoapertures.In particular,we observe from the transmitted light that the scaling of the helicity transformed component with the aperture size is very different to the direct helicity component. | Nora Tischler Ivan Fernandez-Corbaton Xavier Zambrana-Puyalto Alexander Minovich Xavier Vidal Mathieu L Juan Gabriel Molina-Terriza | 2014 | Light(Science & Applications)2014，3，1： | 0 |
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