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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Living related liver transplantation: medical and social aspects of a controversial therapy 显示文摘 | Broelsch CE Testa G Alexandrou A | 2002 | Gut2002，50，2： | 1 |
| 3 | Ammonium complex of niobium as a precursor for the hydrothermal preparation of cellulose acetate/Nb2O5 photocatalyst 显示文摘 | ALEXANDRE G S PRADO ELAINE A | 2005 | Journal of Molecular Catalysis A: Chemical2005，237，12： | 1 |
| 4 | Hard elastic carbon thin films form linking of carbon nanoparticles显示文摘 | Amaratunga G A J Chhowalla M Kiely C J Alexandrou I Aharonov R Devenish R M | 1996 | Nature (London)1996，383，： | 1 |
| 5 | Periodontal thera- py and biomarkers related to cardiovascular risk 显示文摘 | Moura Foz A Alexandre Romito G Manoel Bispo C | 2010 | Minerva Stomatol2010，59，5： | 1 |
| 6 | Comparison between anaerobic threshold determined by ventilatory variables and blood lactate response in cyclists 显示文摘 | ALEXANDRE H O LEANDRO R A HERBERT G S | 2006 | Rev Bras Med Esporte2006，12，1： | 1 |
| 7 | Tem-poral dynamics and genetic diversity of chemotactic-competent microbial populations in the rhizosphere显示文摘 | BUCHAN A CROMBIE B ALEXANDRE G M | 2010 | Environ Microbiol2010，12，12： | 1 |
| 8 | The phytolith ^14C puzzle: A tale of background determinations and accuracy tests 显示文摘 | Santos G M Alexandre A Coe H H G 2010 | 2010 | Radiocarbon2010，52，1： | 1 |
| 9 | A new reactive pulsed laser ablation technique for the deposition of hard carbon and carbon-nitride thin films 显示文摘 | ALEXANDROU 1 ZERGIOTI 1 AMARATUNGA G A J HEALY M J F KIELY C J HATTO P VELEGRAKIS M FOTAKIS C | 1999 | Materials Letters1999，39，： | 1 |
| 10 | An Analysis of destination choice for opaque airline products using multidimensional binary logit models 显示文摘 | Misuk L Alexandre K Laurie A G | 2013 | Transportation Research Part A2013，46，10： | 1 |
| 11 | Possible source of ancient carbon in phytolith concentrates from harvested gras ses显示文摘 | SANTOS G M ALEXANDRE A SOUTHON J R | 2012 | Biogeosciences2012，9，： | 1 |
| 12 | Effect of the pesticide 2,4-Dmicro-bial activity of the soil monitored by micocalorimetry显示文摘 | Alexandre G S P Claudio A | 2000 | Thermochimica Acta2000，349，： | 1 |
| 13 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 14 | Surface-plasmon resonance spectrometry and characterization of absorbing liquids 显示文摘 | ALEXANDRE A K PAUL D G HANS A S | 2000 | Applied Optics2000，39，19： | 1 |
| 15 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 16 | Hyperexpansion of coronary stents and clinical outcomes显示文摘 | ALEXANDRE Q CARLOS A M G EMERSON C P | 2006 | Texas Heart Institute Journal2006，33，： | 1 |
| 17 | Economic implications of using a mean-VaR model for portfolio selection : A comparison with mean-variance analysis显示文摘 | Alexandre G J Baptista A M | 2002 | Journal of Economic Dynamics & Control2002，26，7： | 1 |
| 18 | Experimental investigation of a pulsating heat pipe for hybrid vehicle applications显示文摘 | Burban G Ayel V Alexandre A | | 0，，01： | 1 |
| 19 | The mid- Cretaceous North Atlantic nutrient trap: Black shales and OAEs显示文摘 | Trabucho Alexandre J Tuenter E Henstra G A | 2010 | Paleoceanography2010，25，4： | 1 |
| 20 | A two-dimensional numerical study of the stick-slip extrusion instability显示文摘 | Taliadorou E Georgiou G C Alexandrou A N | 2007 | Journal of Non-Newtonian Fluid Mechanics2007，146，： | 1 |
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