|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 2 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 3 | WNT signaling in ovarian follicle biology and tumorigenesis显示文摘 | Alexandre B Alan K G Derek B | 2009 | Trends in Endocrinology and Metabolism2009，21，1： | 1 |
| 4 | Maintenance of the keratocyte phenotype during cell proliferation stimulated by insulin显示文摘 | Musselmann K Alexandrou B Kane B | 2005 | J Biol Chem2005，280，32： | 1 |
| 5 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 6 | Immunohistochemical expression of caspase-3 as an adverse indicator of the clinical outcome in human breast cancer显示文摘 | Nakopoulou L Alexandrou P Stefanaki K | 2001 | Pathobiology2001，69，5： | 1 |
| 7 | A bibliography of non-deterministic lot-sizing models显示文摘 | Mohamed A A Alexandre D Mikhail Y K | 2014 | International Journal of Production Research2014，52，8： | 1 |
| 8 | SEM observations and differential scanning calorimetric studies of new and sterilized nickel- titanium rotary endodontic instruments 显示文摘 | Alexandrou GB Chrissafis K Vasiliadis LP | 2006 | J Endod2006，32，7： | 1 |
| 9 | Blend Maps: Enhanced Terrain Texturing显示文摘 | Alexandre H Duncan A K | 2006 | Proceedings ofSAICSIT2006，，： | 1 |
| 10 | Emergence of carbapenem resistance in Acinetobacter baumannii in the Czech Republic is associated with the spread of multidrug resistant strains of European clone Ⅱ 显示文摘 | Alexandr N Lenka K Martina M | 2008 | d Antimicrob Chemother2008，62，3： | 1 |
| 11 | Antioxidant and lipophilic constituents of tinosporacrispa 显示文摘 | Alexandre C K urt H Wahio D | 1998 | Planta Medica1998，64，： | 1 |
| 12 | Synthesis of 6-aminopropyl-6H-indolo quinoxaline derivatives显示文摘 | Marina 0 S Nina A K Alexandr V M el a1 | 2012 | ] Heterocyclic Chern2012，49，3： | 1 |
| 13 | The use of microRNAs as re{erence genes for quantitative polymerase chain reaction in soybean 显示文摘 | Franccli R K Francismar C M Alexandre L N | 2010 | Analytical Biochemistry2010，406，2： | 1 |
| 14 | An improved rice transformation system using biolistic method 显示文摘 | Li L C Qu R D Alexandre D K | 1993 | Plant Cell Reports1993，12，： | 1 |
| 15 | Technical aspects and current results of carotid stenting 显示文摘 | Alexandre d'Audiffret PascalD Hicham K | 2001 | J Vasc Surg2001，33，5： | 1 |
| 16 | Absorptive Capacity, Innovation, and Financial Performance显示文摘 | Konstantinos K Alexandres P Margarita P | 2011 | Journal of Business Research2011，64，12： | 1 |
| 17 | An Analysis of destination choice for opaque airline products using multidimensional binary logit models 显示文摘 | Misuk L Alexandre K Laurie A G | 2013 | Transportation Research Part A2013，46，10： | 1 |
| 18 | A scalable architecture for modular multiplication based on montgomery's algorithm显示文摘 | Alexandre F Tenca cetin K | 2003 | IEEE Transactions on Computers2003，52，9： | 1 |
| 19 | Cost effective- ness of posaconazole versus fluconazole/itraconazole in the prophylactic treatment of invasive fungal infections in Mexico显示文摘 | RELY K ALEXANDRE PK ESCUDERO GS | 2011 | Value Health2011，14，5： | 1 |
| 20 | Microarray profiling for differential gene expression in ovaries and ovarian follicles of pigs selected for increased ovulation rate显示文摘 | ALEXANDRE R C JOHNSON R K FORD J J | 2004 | Genetics2004，168，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员