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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 3 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 4 | Preparation and properties of layered silicate nanocomposites based on ethylene vinyl acetate copolymers显示文摘 | ALEXANDRE M BEYER G HENRIST C | 2001 | Rapid Commun2001，22，： | 1 |
| 5 | Hard elastic carbon thin films form linking of carbon nanoparticles显示文摘 | Amaratunga G A J Chhowalla M Kiely C J Alexandrou I Aharonov R Devenish R M | 1996 | Nature (London)1996，383，： | 1 |
| 6 | Brazilian ginseng extraction via LPSE and SFE: global yields, extraction kinetics, chemi- cal composition and antioxidant activity显示文摘 | LEAL P F KFOURI M B ALEXANDRE F C | 2010 | The Journal of Supercriti- eal Fluids2010，54，： | 1 |
| 7 | The use of microRNAs as re{erence genes for quantitative polymerase chain reaction in soybean 显示文摘 | Franccli R K Francismar C M Alexandre L N | 2010 | Analytical Biochemistry2010，406，2： | 1 |
| 8 | Comparative membrane interaction study of viscotoxins A3,A2,and B from mistletoe (Viscum album) and connection s with their structures显示文摘 | Alexandre C Amor M Andre L | | 0，，： | 1 |
| 9 | A new reactive pulsed laser ablation technique for the deposition of hard carbon and carbon-nitride thin films 显示文摘 | ALEXANDROU 1 ZERGIOTI 1 AMARATUNGA G A J HEALY M J F KIELY C J HATTO P VELEGRAKIS M FOTAKIS C | 1999 | Materials Letters1999，39，： | 1 |
| 10 | A natural clouding agent from orange peels obtained using polygalacturonase and cellulase 显示文摘 | Alexandre E B Robert C S F Olga M B | 2005 | Food Chemistry2005，92，1： | 1 |
| 11 | 显示文摘 | M Alexandre G Beyer C Henrist Ed | 2001 | Chem Mater2001，13，11： | 1 |
| 12 | A lattice gas model for erosion and particles transport in a fluid 显示文摘 | BASTIEN C ALEXANDRE M ALEXANDRE D | 2000 | Computer Physics Communications2000，129，： | 1 |
| 13 | Investigation of carbon nitride films by cathodic arc evaporation显示文摘 | Alexandrou I Kiely C | 1996 | Thin Solid Films1996，，： | 1 |
| 14 | Considering temporal variations of spatial visual distortion in video quality assess- ment 显示文摘 | ALEXANDRE N OLIVIER L M PATRICK L C | 2009 | 1EEE Journal of Selected Topics in Signal Processing2009，3，2： | 1 |
| 15 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 16 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 17 | Hyperexpansion of coronary stents and clinical outcomes显示文摘 | ALEXANDRE Q CARLOS A M G EMERSON C P | 2006 | Texas Heart Institute Journal2006，33，： | 1 |
| 18 | 2015, Microbial community structure mediates response of soil C decomposition to litter addition and warming 显示文摘 | COURTNEY A C Alexandre B M Evelyn S K | 2015 | Soil Biology and Biochemistry2015，80，： | 1 |
| 19 | The orexin type 1 re- ceptor is overexpressed in advanced prostate cancer with a neuro- endocrine differentiation, and mediates apoptosis 显示文摘 | Alexandre D Hautot C Mehio M | 2014 | Eur J Cancer2014，50，： | 1 |
| 20 | Transesterification catalysts to improve clay exfoliation in synthetic biodegradable polyester nanocomposites显示文摘 | Pollet E Delcourt C Alexandre M | 2006 | European Polymer Journal2006，42，6： | 1 |
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