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| 1 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 2 | Acute cholestatic hepatitis caused by amoxicillin/ clavulanate显示文摘Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used,especially for the treatment of respiratory and cutaneous infections.In general,it is a well-tolerated oral antibiotic.However,amoxicillin/clavulanate can cause adverse effects,mainly cutaneous,gastrointestinal,hepatic and hematologic,in some cases.Presented here is a case report of a 63-yearold male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate.After 6 wk of prolonged use of the drug,he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia(total bilirubin>300 mg/L).Diagnostic investigation was conducted by ultrasonography of the upper abdomen,serum tests for infection history,laboratory screening of autoimmune diseases,nuclear magnetic resonance(NMR)of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound.The duration of disease was approximately 4 mo,with complete resolution of symptoms and laboratory changes at the end of that time period.Specific treatment was not instituted,only a combination of anti-emetic(metoclopramide)and cholestyramine for pruritus. | Daniel Oliveira Beraldo Joanderson Fernandes Melo Alexandre Vidal Bonfim Andrei Alkmim Teixeira Ricardo Alkmim Teixeira André Loyola Duarte | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 3 | SIGLa: an adaptable LIMS for multiple labo- ratories 显示文摘 | Alexandre Melo Alessandra Faria-Campos Daiane Mari- ele DeLaat | 2010 | BMC GENOMICS2010，1，5： | 1 |
| 4 | Calibration of low frequency magnetic field meters using a Helmholtz coil显示文摘 | Celso Fabricio de Melo Ricardo Luiz Araújo Leonardo Morozowski Ardjomand Nilton S. Ramos Quoirin Minoru Ikeda Alexandre Albarello Costa | 2009 | Measurement2009，，9： | 1 |
| 5 | A theoretical interpretation of the color of two classes of pyranoanthocyanins显示文摘 | Alexandre R.F. Carvalho Joana Oliveira Victor de Freitas Nuno Mateus André Melo | 2010 | Journal of Molecular Structure: THEOCHEM2010，，1： | 1 |
| 6 | A computational study of vinylpyranoanthocyanin-phenolic pigments (portisins)显示文摘 | Alexandre R.F. Carvalho Joana Oliveira Victor de Freitas Artur Silva Nuno Mateus André Melo | 2009 | Journal of Molecular Structure: THEOCHEM2009，，1： | 1 |
| 7 | First-Line Paclitaxel and Carboplatin in Persistent/Recurrent or Advanced Cervical Cancer: A Retrospective Analysis of Patients Treated at Brazilian National Cancer Institute显示文摘 | álvaro Henrique Ingles Garces Paulo Alexandre Ribeiro Mora Flávia Vieira Guerra Alves Claudio Calazan do Carmo Rachele Grazziotin Anna Cristina Ferr?o Mangia Fernandes Angélica Nogueira-Rodrigues Andréia Cristina de Melo | 2013 | International Journal of Gynecological Cancer2013，，4： | 1 |
| 8 | Clinical and radiographic features of Hutchinson-Gilford progeria syndrome: A case report显示文摘Hutchinson-Gilford progeria syndrome(HGPS) is a rare dysmorphic syndrome characterized by several features of premature aging with clinical involvement of the skin, bones, and cardiovascular system. HGPS has an estimated incidence of one in four million to one in eight million births. The main clinical features of HGPS include short stature, craniofacial dimorphism, alopecia, bone fragility, and cardiovascular disorders. The most frequent cause of death is myocardial infarction at a mean age of 13 years old. Dental manifestations include delayed development and eruption of teeth, discoloration, crowding and rotation of teeth, and displaced teeth. Cone beam computed tomography images revealed the absence of the sphenoid, frontal, and maxillary sinus, flattening of the condyles and glenoid fossa, and bilateral hypoplasia of the mandibular condyles. The disease is caused by mutations in lamin A/C(LMNA). Here, we present a case report of an 11-year-old boy with classical features of HGPS, which was caused by a de novo germ-line mutation(C1824T, G608G) in exon 11 of the LMNA gene. Some uncommon HGPS-associated features in our patient, such as alterations in the facial sinuses and hypoplasia of the condyles, contributed to the expansion of the phenotypic spectrum of this syndrome from a dentomaxillofacial perspective. | Daniel Berretta Alves Juliana Melo Silva Tatiany Oliveira Menezes Rosely Santos Cavaleiro Fabrício Mesquita Tuji Marcio Ajudarte Lopes Alexandre Augusto Zaia Ricardo Della Coletta | 2014 | World Journal of Clinical Cases2014，2，3： | 0 |
| 9 | Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)polymorphisms with protection and susceptibility to dengue in Brazilian population显示文摘Objective: To evaluate gene polymorphisms and their association with susceptibility to dengue.Methods: A retrospective case-control study was performed with 262 subjects,comprising 78 dengue fever(DF) patients, 49 dengue hemorrhagic fever(DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation system.Results: We observed a protective association of IL-10(-819 C/T) C allele(P = 0.028,OR = 0.56, CI = 0.34–0.91) against DHF, while the C/T(P = 0.047, OR = 2.10,CI = 1.01–4.38) and T/T(P = 0.008, OR = 3.82, CI = 1.38–10.59) genotypes were associated with DHF and DF, respectively. The dominant model TNFA-308 GA + AA(P = 0.043, OR = 0.45, CI = 0.20–1.00) genotypes were found to have protective effect against dengue infection. A protective association among the IFNG(+874 A/T) A/T genotype against DF(P = 0.02, OR = 0.46, CI = 0.24–0.89) and DHF(P = 0.034,OR = 0.43, CI = 0.19–0.95) was observed. When the studied single-nucleotide polymorphism was analyzed in combination, the combination GTA(P = 0.022, OR = 2.95,CI = 1.18–7.41) was statistically significantly associated with susceptibility to DF and the combination GCT(P = 0.035, OR = 0.28, CI = 0.08–0.90) with protection against the development of DHF.Conclusions: This research identifies the association of the IFNG(+874 A/T), TNFA(-308 G/A), IL-10(-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue. | Ana Caroline Melo dos Santos Edilson Leite de Moura Jean Moises Ferreira Alexandre Wendell Araujo de Moura Ailson Darlan Sales Ferreira Rubens Pereira Bezerra Diego de Siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia Martins de Souza Figueiredo | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 0 |
| 10 | Parasite Fauna of Lutjanus synagris Commercialized in the Fish Market from Bragança-PA,Brazil显示文摘Studies about the parasite fauna of marine fish highlights as an important problem for public health with zoonotic parasites or affecting the fish quality.Thus,this study evaluated the parasite fauna of Lutjanus synagris commercialized in the fish market from Bragança-PA.In laboratory,58 fish were measured,weighted and conducted to parasitological analysis to determine parasitological indexes and relative dominance.Every parasite was fixed and identified until to the lowest taxonomic level.Through the parasitological analysis,it found Cymothoidae,Digenea,Cucullanus sp.and Procamallanus(Spirocamallanus)sp.,with total prevalence 67.24%.Digenea showed the highest prevalence and mean intensity values.For nematode,Cucullanus sp.obtained the greater prevalence and relative dominance,while Procamallanus(Spirocamallanus)sp.showed the greater mean intensity and abundance.Cymothoidae showed the lowest prevalence and mean intensity values.As conclusion,the parasite fauna of L.synagris has been noted with low diversity,reporting the nematode occurrence Procamallanus(Spirocamallanus). | Natalino da Costa Sousa Daiana Silva dos Santos Silmara Rosa Silva Alexandre Vaz da Silva Jucimauro de Araújo P.Junior João Vitor Antunes Miranda Pedro Rodrigo Nery de Souza Matheus Carvalho de Melo Fagner de Melo Xavier Wellington Lima da Silva Junior Fabricio Ramos Menezes Márcia Valeria Silva do Couto | 2019 | Journal of Zoological Research2019，1，3： | 0 |
| 11 | Carbonates and organic matter in soils characterized by reflected energy from 350-25000 nm wavelength显示文摘The soil carbon pool which is the sum of soil organic carbon(SOC)and soil inorganic carbon(SIC)is the second largest active store of carbon after the oceans and it is an important component of the global carbon cycle.Hence,accurate estimation of SOC and SIC as important carbon reservoirs in terrestrial ecosystems using fast,inexpensive and non-destructive methods is crucial for planning different climate change policies.The aim of the current research was to examine the effectiveness of Vis-NIR(visible and near-infrared spectroscopy:350-2500 nm)and MIR(mid-infrared spectroscopy:4000-400 cm-1)to characterize and estimate soil organic matter(SOM)and carbonates as main components of soil carbon stocks in Juneqan,Charmahal va Bakhtiari,Iran.To do so,a total of 548 soil samples from this area were collected(October 2015)and analyzed in laboratory(August 2017).In order to develop models capable of predicting SOM and carbonates content,seven spectral preprocessing methods comprising Absorbance(Abs),De-trending(Det),Continuum removal(CR),Savitzky-Golay derivatives(SGD),standard normal variate transformation(SNV),multiplicative scatter correction(MSC)and Normalization by range(NBR)were conducted along with five multivariate methods including Random Forest(RF),Partial Least-Squares Regression(PLSR),Artificial Neural Network(ANN),Support Vector Machine(SVM)and Gaussian Process Regression(GPR).The content of carbonates caused spectral reflectance intensity to augment on several ranges of spectrum and strong absorption feature at 2338 nm in the Vis-NIR and 714,850,870,1796,2150 and 2510 cm-1 in the MIR spectra range.SOM absorbed energy in several ranges,but also showed specific peaks in MIR.Both facts are associated with the structure of carbonates and SOM and its interaction with energy.The best combination of preprocessing and calibration models for carbonates quantification in Vis-NIR spectra was Det/PLSR(R2=0.74,RPD=2.19,RMSE=6.45).For SOM,it was Det/PLSR(R2=0.82,RPD=2.41,RMSE=0.75).The Det/RF(R2=0.87,RPD=2.44,RMSE=0.66)for the quantification of SOM and MSC/RF(R2=0.84,RPD=2.84,RMSE=5.50)for carbonates in MIR spectra range showed the greatest results.The stronger occurrence of spectral bands in MIR as well as the specificity of the absorption features indicated that this range produced better predictions.The obtained results highlighted the significant role of soil spectroscopy technique in predicting SOC and soil carbonates as key components of soil carbon stocks in the study area.Therefore,this technique can be used as a more cost-effective,time saving and nondestructive alternative to traditional methods of soil analysis. | Najmeh ASGARI Shamsollah AYOUBI Jose Alexandre Melo DEMATTê AndréCarnieletto DOTTO | 2020 | Journal of Mountain Science2020，17，7： | 0 |
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