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| 1 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets显示文摘Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the metabolic syndrome. NAFLD is classified as nonalcoholic fatty liver(NAFL) or simple steatosis,and non-alcoholic steatohepatitis(NASH). NASH is characterized by the presence of steatosis and inflammation with or without fibrosis. The physiopathology of NAFL and NASH and their progression to cirrhosis involve several parallel and interrelated mechanisms,such as,insulin resistance(IR),lipotoxicity,inflammation,oxidative stress,and recently the gut-liver axis interaction has been described. Incretin-based therapies could play a role in the treatment of NAFLD. Glucagon-like peptide-1(GLP-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion,inhibition of postprandial glucagon secretion and delayed gastric emptying. It also promotes weight loss and is involved in lipid metabolism. Once secreted,GLP-1 is quickly degraded by dipeptidyl peptidase-4(DPP-4). Therefore,DPP-4 inhibitors are able to extend the activity of GLP-1. Currently,GLP-1 agonists and DPP-4 inhibitors represent attractive options for the treatment of NAFLD and NASH. The modulation of lipid and glucose metabolism through nuclear receptors,such as the farsenoid X receptor,also constitutes an attractive therapeutic target. Obeticholic acid is a potent activator of the farnesoid X nuclear receptor and reduces liver fat content and fibrosis in animal models. Ursodeoxycholic acid(UDCA) is a hydrophilic bile acid with immunomodulatory,antiinflammatory,antiapoptotic,antioxidant and antifibrotic properties. UDCA can improve IR and modulate lipid metabolism through its interaction with nuclear receptors such as,TGR5,farnesoid X receptor-a,or the small heterodimeric partner. Finally,pharmacologic modulation of the gut microbiota could have a role in the therapy of NAFLD and NASH. Probiotics prevent bacterial translocation and epithelial invasion,inhibit mucosal adherence by bacteria,and stimulate host immunity. In animal models,probiotics prevent obesity,decrease transaminase levels,and improve IR and liver histology in NASH. | Fatima Higuera-de la Tijera Alfredo I Servin-Caamano | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 3 | Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients显示文摘 | Antonio Facciorusso Valentina Del Prete Nicola Crucinio Nicola Muscatiello Brian I Carr Alfredo Di Leo Michele Barone | 2015 | J Gastroenterol Hepatol2015，，11： | 2 |
| 4 | Mean platelet volume as a novel predictor of systematic inflammatory response in cirrhotic patients with culturenegative neutrocytic ascites显示文摘AIM: To identify a mean platelet volume(MPV) cutoff value which should be able to predict the presence of bacterial infection.METHODS: An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of 'Hospital General de México Dr. Eduardo Liceaga', we included 51 cirrhotic patients with ascites fluid infection(AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid infection.RESULTS: Of the 51 cases with AFI, 48 patients(94.1%) had culture-negative neutrocytic ascites(CNNA), 2(3.9%) had bacterial ascites, and one(2%)had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency(P < 0.0001), and lower mean arterial pressure compared with non-infected patients(P = 0.009). Leucocytes, polymorphonuclear count, MPV and cardiac frequency resulted to be good or very good predictive variables of presence of AFI in cirrhotic patients(area under the receiving operating characteristic > 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection. CONCLUSION: Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA. | Marisol Galvez-Martinez Alfredo I Servin-Caamano Eduardo Perez-Torres Francisco Salas-Gordillo Xaira Rivera-Gutierrez Fatima Higuera-de la Tijera | 2015 | World Journal of Hepatology2015，7，7： | 2 |
| 5 | Cytotoxic, hepatoprotective and free radical scavenging effects of propolis from Brazil, Peru, the Netherlands and China显示文摘 | Arjun H Banskota Yasuhiro Tezuka I Ketut Adnyana Kiyoshi Midorikawa Katsumichi Matsushige Dejair Message Alfredo A.G Huertas Shigetoshi Kadota | 2000 | Journal of Ethnopharmacology2000，，1： | 1 |
| 6 | Effect of selected aldehydes on the growth and fermentation of ethanologenic Escherichia coli显示文摘 | JESUS Z ALFREDO M LONNIE I | 1999 | Biotechnol Bioeng1999，65，1： | 1 |
| 7 | Easy gesture recognition for Kinect 显示文摘 | Rodrigo I Alvaro S Alfredo T | 2014 | Advances in Engineering Software2014，76，： | 1 |
| 8 | Experi- mental fuel cell performance analysis under different operating conditions and bipolar plate designs 显示文摘 | Alfredo I Miguel M Eduardo L | 2010 | International Journal of Hydrogen Energy2010，35，11： | 1 |
| 9 | Transient heat conduetion analysis using a boundary element method based on the convolution quadrature method 显示文摘 | Ana I Abreu Alfredo Canelasb Webe J Mansur | 2010 | Mecanica Computacional2010，29，11： | 1 |
| 10 | Numerical investigation of the effect of impeller design parameters on the performanee of a multiphase baffle - stirred reactor 显示文摘 | Alfredo I Ruben B Jeronimo D | 2011 | Chemical Engineering Technology2011，4，8： | 1 |
| 11 | Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase显示文摘 | Usune Etxeberria Ana Laura de la Garza Javier Campió n J Alfredo Martí nez Fermí n I Milagro | 2012 | Expert Opinion on Therapeutic Targets2012，，3： | 1 |
| 12 | Prediction of renal functional recovery after relief of upper urinary tract obstruction显示文摘 | Valey K A Richard H A Alfredo I L | 1981 | Urol1981，126，： | 1 |
| 13 | Prediction of renal functional recovery after relief of upper urinary tract obstruction显示文摘 | Valery K A Richard H A Alfredo I L | 1981 | J Urol1981，126，： | 1 |
| 14 | Influence of the blend viscosity and interface energies on the preferential location of CB and conductivity of BR/EPDM blends 显示文摘 | Rigoberto I Alfredo M Luis F | 2003 | Rubber Chemistry and Technology2003，76，4： | 1 |
| 15 | Iterative algorithms for equilibrium problems显示文摘 | ALFREDO N I WILFREDO S | 2003 | Optimization2003，52，3： | 1 |
| 16 | Prediction of renal functional recovery after relief of upper urinary tract obstruction显示文摘 | Valery K A Richard H A Alfredo I L | 1981 | J Uro11981，126，3： | 1 |
| 17 | Pre-transplant treatment of large polycystic kidney显示文摘AIM: To evaluate the indications, optimal timing andoutcomes of native nephrectomy and other techniques in pretransplant treatment of autosomal dominant polycystic kidney disease(PKD).METHODS: A literature review was conducted using the Pub Med and Epistemonikos databases. Keywords for pre-transplant surgical management of polycystic kidneys were: Transplant, treatment and PKD. Keywords for pre-treatment embolization of PKD were: Embolization, transplant and polycystic kidney disease. The inclusion criterions were all articles found using this search method. The exclusion criterions were articles found to include bias and not attending pre-transplant treatment options. Fifteen articles were included in our final analysis. Ten articles were found regarding embolization of PKD of which three reviews were selected for final analysis. The reviews were divided into pre transplant and intra transplant treatment for the surgical treatment of PKD. All articles meeting inclusion criteria were thoroughly analyzed by two independent reviewers. A third independent reviewer was consulted if the reviewers did not agree upon the inclusion or exclusion of a specific article. No statistical analysis was performed.RESULTS: Studies vary regarding the technique used(open or laparoscopic), laterality(single or bilateral) and temporality of nephrectomy with respect to renal transplant(pre-transplant or simultaneous to transplant). Several groups argue in favor of simultaneous nephrectomy and kidney transplant since it avoids the deleterious effects of being anefric. Long-term results and patient satisfaction are acceptable. However, it is associated with increased operative time, transfusion rate, morbidity and length of hospital stay. Based on small sample studies, bilateral nephrectomy prior to transplant has been associated with a higher risk of morbidity and mortality. Studies on laparoscopic approach report it as a feasible and safe alternative to the open surgery approach, highlighting its lower complication rate, transfusions and shorter hospital stay. Arterial embolization of the kidney appears as an effectiveand low morbid alternative for the management of large native kidneys. The reduction in renal size allow transplant in a significant number of patients, which makes it an appealing alternative to surgery.CONCLUSION: There is limited evidence regarding best pretrasnplant treatment of large PKD but to date embolization seems an appealing alternative to augment space for renal graft allocation. | Iván D Sáez Juan F de la Llera Andrés Tapia Rodrigo A Chacón Pedro A Figueroa Bruno I Vivaldi Alfredo Domenech Christopher D Horn Fernando Coz | 2016 | World Journal of Clinical Urology2016，5，1： | 0 |
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