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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Insights from the fungus Fusarium oxysporum point to high affinity glucose transporters as targets for enhancing ethanol production from lignocellulose显示文摘 | ALI S S NUGENT B MULLINS E | 2013 | PLoS One2013，8，1： | 1 |
| 3 | Methyl jasmonate and salicyli acid induced oxidative stress and accumulation of phenolics in Panax ginseng bioreactor root suspension cultures显示文摘 | Ali M B Hahn E J Paek K Y | 2007 | Mole cules2007，12，3： | 1 |
| 4 | Deep desulp Hurzation of gasoline and diesel fuels using non-hydrogen consuming techniques显示文摘 | ALI M F MALKI A A ALI B E | 2006 | Fuel2006，85，1011： | 1 |
| 5 | Cumulative pore volume, pore size distribution and phases percolation in porous inorganic polymer composites: Relation microstruc?ture and effective thermal conductivity 显示文摘 | Kamseu E Ngouloure Z N M Ali B N | 2015 | Energy Build2015，88，： | 1 |
| 6 | ADVISOR-based model of a battery and an ultra-capacitor energy source for hybrid electric vehicles显示文摘 | Andrew C B Ali E | 2004 | IEEE Transactions on Vehicular Technology2004，53，1： | 1 |
| 7 | Effects of temperature on oxidative stress defense systems,lipid peroxidation and lipoxygenase activity in Phalae- nopsis显示文摘 | ALI M B HAHN E J PAEK K Y | 2005 | Plant Physiol Biochem2005，43，： | 1 |
| 8 | Strategies of Heavy Metal Uptake by Three Plant Species Grow ing Near a Metal Smelter显示文摘 | van Oort F G(e)Alie B | 2000 | Environmental Pollution2000，109，： | 1 |
| 9 | Effects of temperature on oxidative stress defense systems, lipid peroxidation and lipoxygenase activity in Phalaenopsis 显示文摘 | Ali M B Hahn E J Paek K Y | 2005 | Plant Physiology and Biochemisty2005，43，3： | 1 |
| 10 | Myosin Va maneuvers through actin intersections and diffuses along microtubules 显示文摘 | Ali M Y Krementsova E B | 2007 | PNAS2007，4，11： | 1 |
| 11 | In2O3 deposited by reactive evaporation of indium in oxygen atmosphere-influence of post- annealing treatment on optical and electrical properties显示文摘 | Ali E B Maliki H E Bemede J C | 2002 | Materials Chemistry and Physics2002，73，： | 1 |
| 12 | Photosynthetic pigments,morphol-ogy and leaf gas exchange during exvitro acclimatization of micropropagatedCAM Doritaenopsis plantlets under relative humidity and air temperature显示文摘 | JEON M W ALI M B HAHN E J | 2006 | Environmental and Experimental Botany2006，55，： | 1 |
| 13 | Effects of temperature on oxidative stress defense systems,lipid peroxidation and lipoxygenase activity in Phalaenopsis显示文摘 | Ali M B Hahn E - J Paek K - Y | 2005 | Plant Physiology and Biochemistry2005，43，： | 1 |
| 14 | Emotional and learning capability and their impact on product innova tiveness and firm performance显示文摘 | ALI E A HALIT K JOHN C B | 2007 | Technovation2007，，27： | 1 |
| 15 | Enhancement ofphenylpropanoid enzymes and lignin in Phalaenopsis orchid andtheir influence on plant acclimatisation at different levels ofphotosynthetic photon flux显示文摘 | Ali M B Khatun S Hahn E J | 2006 | Plant Growth Regulation2006，49，23： | 1 |
| 16 | In2O3 Deposited by Reactive Evaporation of Indium in Oxygen Atmosphere-influence of Post-annealing Treatment on Optical and Electrical Properties显示文摘 | Ali E B El Maliki H Bemede J C | 2002 | Materials Chemistry and Physics2002，73，1： | 1 |
| 17 | Effects of temperature on oxidative stress defense systems, lipid peroxidation and lipoxygenase activity in Phalaenopsis显示文摘 | Ali M B Hahn E J Paek K Y | 2005 | Plant Physiology and Biochemistry2005，43，3： | 1 |
| 18 | Methyl jamonate and salicylic acid elicitation induces ginsenoside accumulation, errzymatie and non-enzyme tieantr oxidant in suspension culture Panax ginseng roots in bioreactors 显示文摘 | Ali M B Yu K W Hahn E J | 2006 | Plant Cell Rep2006，25，： | 1 |
| 19 | Effects of temperature on oxidative stress defense systems, lipid peroxidation and lipoxygenase activity in Phalaenopsis显示文摘 | ALI M B HAHN E J PAEK K Y | 2005 | Plant PhysiolBiochem2005，43，： | 1 |
| 20 | Methyl jasmonate and sali- cylic acid eliciation induces ginsenosides accumulation, enzymatic and non-enzymatic anti-oxidant in suspension culture Panax gin- seng roots in bioreactors 显示文摘 | Ali M B Yu K W Hahn E J | 2006 | Plant Cell Rep2006，25，： | 1 |
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