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| 1 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 2 | A critical role for nitric oxide in intestinal barrier function and dysfunction显示文摘 | Alican I Kubes P | 1996 | Am J Physiol1996，270，32： | 1 |
| 3 | The comorbidity of adult attention-deficit/hyperactivity disorder in bipolar disorder patients 显示文摘 | Elif K Numan K Alican D | 2013 | Comprehensive Psychiatry2013，54，5： | 1 |
| 4 | A critical role for nitric oxide in intestinal barrier function and dysfunction显示文摘 | Alican I Kubes P | 1996 | Am J Physiol1996，270，32： | 1 |
| 5 | Removal of propham from water by using electro-Fenton technology: Kinetics and mechanism显示文摘 | Alican Yucel Sahin Mehmet A | 2008 | Chemosphere2008，73，： | 1 |
| 6 | The effect of thermal injury on gastric emptying in rats显示文摘 | Alican I Coskun T Yegen C | 1995 | Burns1995，21，3： | 1 |
| 7 | An ultra-compact particle size analyser using a CMOS image sensor and machine learning显示文摘Light scattering is a fundamental property that can be exploited to create essential devices such as particle analysers.The most common particle size analyser relies on measuring the angle-dependent diffracted light from a sample illuminated by a laser beam.Compared to other non-light-based counterparts,such a laser diffraction scheme offers precision,but it does so at the expense of size,complexity and cost.In this paper,we introduce the concept of a new particle size analyser in a collimated beam configuration using a consumer electronic camera and machine learning.The key novelty is a small form factor angular spatial filter that allows for the collection of light scattered by the particles up to predefined discrete angles.The filter is combined with a light-emitting diode and a complementary metal-oxide-semiconductor image sensor array to acquire angularly resolved scattering images.From these images,a machine learning model predicts the volume median diameter of the particles.To validate the proposed device,glass beads with diameters ranging from 13 to 125μm were measured in suspension at several concentrations.We were able to correct for multiple scattering effects and predict the particle size with mean absolute percentage errors of 5.09% and 2.5% for the cases without and with concentration as an input parameter,respectively.When only spherical particles were analysed,the former error was significantly reduced(0.72%).Given that it is compact(on the order of ten cm)and built with low-cost consumer electronics,the newly designed particle size analyser has significant potential for use outside a standard laboratory,for example,in online and in-line industrial process monitoring. | Rubaiya Hussain Mehmet Alican Noyan Getinet Woyessa Rodrigo R.Retamal Marin Pedro Antonio Martinez Faiz M.Mahdi Vittoria Finazzi Thomas A.Hazlehurst Timothy N.Hunter Tomeu Coll Michael Stintz Frans Muller Georgios Chalkias Valerio Pruneri | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 8 | Bombesin improves burn-induced intestinal injury in the rat显示文摘 | Alican I Unluer EE Yegen C | 2000 | Peptides2000，21，8： | 1 |
| 9 | A critical role for nitric oxide inintes tinal barrier function and dysfunction显示文摘 | Alican I Kubes P | 1996 | Am J Physiol1996，270，21： | 1 |
| 10 | Study on overall heat transfer coeffient for a rotating cavity type heat exchanger 显示文摘 | Alican Daloglu | 1999 | International Communications in Heat and Mass Transfer1999，26，6： | 1 |
| 11 | Study on overall heat transfer coeffient for a rotating cavity type heat exchanger显示文摘 | Alican Daloglu | 1999 | International Communications in Heat and Mass Transfer1999，26，6： | 1 |
| 12 | A critical role for nitric oxide in intestinal barrier function and dysfunction显示文摘 | Kubes P | 1996 | Am J Hysiol1996，270，： | 1 |
| 13 | Adenosine Protects Against Indomethacin-Induced Gastric Damage in Rats显示文摘 | Ayhan Bozkurt Meral Yuksel Goncagul Haklar Hizir Kurtel Berrak C. Yegen Inci Alican | 1998 | Digestive Diseases and Sciences1998，，6： | 1 |
| 14 | A critical role for nitric oxide in intestinal barrier function and dysfunction 显示文摘 | Alican I Kubes P | 1996 | Am J Physiol1996，270，21： | 1 |
| 15 | Ankle-foot orthosis:effect on gait in children with cerebral palsy显示文摘 | Dursun E Dursun N Alican D | 2002 | Disabil Rehabil2002，24，7： | 1 |
| 16 | The Theory of Reasoned A- cion Applied to Coupon Usage 显示文摘 | Shimp Terence and Alican Kavas | 1984 | Journal of Consumer Re- search1984，11，3： | 1 |
| 17 | Intestinal transplantation: laboratory experience and a report of a clinical case显示文摘 | Alican F Hardy JD Cayirili M | 1971 | Am J Sttrg1971，121，： | 1 |
| 18 | Ankle-foot orthosis: effect on gait in children with cerebral palsy显示文摘 | Dursun E Dursun N Alican D | 2002 | Disabil Rehabil2002，24，7： | 1 |
| 19 | Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis显示文摘 | Isman CA Yegen BC Alican I | 2003 | J Endocrinol2003，177，3： | 1 |
| 20 | The Theory of Rea- soned Action Applied to Coupon Usage 显示文摘 | Shimp Terence Alican Kavas | 1984 | Journal of Consumer Research1984，11，3： | 1 |
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