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2篇 您的检索式：作者名="Alice A. LIN"

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		题名	作者	年代	出处	被引量
	1	Molecular Evolution of CXCR1, a G Protein-Coupled Receptor Involved in Signal Transduction of Neutrophils显示文摘	Ying Liu Su Yang Alice A. Lin Luca L. Cavalli-Sforza Bing Su	2005	Journal of Molecular Evolution2005，，5：	1
	2	Detecting positive darwinian selection in brain-expressed genes during human evolution显示文摘To understand the genetic basis that underlies the phenotypic divergence between human and non- human primates, we screened a total of 7176 protein-coding genes expressed in the human brain and compared them with the chimpanzee orthologs to identify genes that show evidence of rapid evolution in the human lineage. Our results showed that the nonsynonymous/synonymous substitution (Ka/Ks) ratio for genes expressed in the brain of human and chimpanzee is 0.3854, suggesting that the brain-expressed genes are under functional constraint. The X-linked human brain-expressed genes evolved more rapidly than autosomal ones. We further dissected the molecular evolutionary patterns of 34 candidate genes by sequencing representative primate species to identify lineage-specific adaptive evolution. Fifteen out of the 34 candidate genes showed evidence of positive Darwinian selection in human and/or chimpanzee lineages. These genes are predicted to play diverse functional roles in em- bryonic development, spermatogenesis and male fertility, signal transduction, sensory nociception, and neural function. This study together with others demonstrated the usefulness and power of phy- logenetic comparison of multiple closely related species in detecting lineage-specific adaptive evolu- tion, and the identification of the positively selected brain-expressed genes may add new knowledge to the understanding of molecular mechanism of human origin.	QI XueBin YANG Su ZHENG HongKun WANG YinQiu LIAO ChengHong LIU Ying CHEN XiaoHua SHI Hong YU xiaoJing Alice A. LIN Luca L. CAVALLI-SFORZA WANG Jun SU Bing	2007	Chinese Science Bulletin2007，52，3：	0

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