5篇
您的检索式：作者名="Alice Groves"
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| 1 | Breath Biopsy^(®) to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection显示文摘Background and Aims:The prevalence of chronic liver dis-ease in adults exceeds 30%in some countries and there is significant interest in developing tests and treatments to help control disease progression and reduce healthcare burden.Breath is a rich sampling matrix that offers non-invasive so-lutions suitable for early-stage detection and disease moni-toring.Having previously investigated targeted analysis of a single biomarker,here we investigated a multiparametric approach to breath testing that would provide more robust and reliable results for clinical use.Methods:To identify can-didate biomarkers we compared 46 breath samples from cir-rhosis patients and 42 from controls.Collection and analysis used Breath Biopsy OMNI™,maximizing signal and contrast to background to provide high confidence biomarker detec-tion based upon gas chromatography mass spectrometry(GC-MS).Blank samples were also analyzed to provide de-tailed information on background volatile organic compounds(VOCs)levels.Results:A set of 29 breath VOCs differed significantly between cirrhosis and controls.A classification model based on these VOCs had an area under the curve(AUC)of 0.95±0.04 in cross-validated test sets.The seven best performing VOCs were sufficient to maximize classifica-tion performance.A subset of 11 VOCs was correlated with blood metrics of liver function(bilirubin,albumin,prothrom-bin time)and separated patients by cirrhosis severity using principal component analysis.Conclusions:A set of seven VOCs consisting of previously reported and novel candidates show promise as a panel for liver disease detection and mon-itoring,showing correlation to disease severity and serum biomarkers at late stage. | Giuseppe Ferrandino Giovanna De Palo Antonio Murgia Owen Birch Ahmed Tawfike Rob Smith Irene Debiram-Beecham Olga Gandelman Graham Kibble Anne Marie Lydon Alice Groves Agnieszka Smolinska Max Allsworth Billy Boyle Marc P.van der Schee Michael Allison Rebecca C.Fitzgerald Matthew Hoare Victoria K.Snowdon | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 2 | Benefits of Liraglutide Treatment in Overweight and Obese Older Individuals With Prediabetes显示文摘 | Sun H. Kim Fahim Abbasi Cindy Lamendola Alice Liu Danit Ariel Patricia Schaaf Kaylene Grove Vanessa Tomasso Hector Ochoa Yeheng V. Liu Yii-Der Ida Chen Gerald Reaven | 2013 | Diabetes Care2013，，10： | 1 |
| 3 | Pancreatic beta cell function following liraglutide-augmented weight loss in individuals with prediabetes: analysis of a randomised, placebo-controlled study显示文摘 | Sun H. Kim Alice Liu Danit Ariel Fahim Abbasi Cindy Lamendola Kaylene Grove Vanessa Tomasso Gerald Reaven | 2014 | Diabetologia2014，，3： | 1 |
| 4 | Benefits of Liraglutide Treatment in Overweight and Obese Older Individuals With Prediabetes显示文摘 | Sun H. Kim Fahim Abbasi Cindy Lamendola Alice Liu Danit Ariel Patricia Schaaf Kaylene Grove Vanessa Tomasso Hector Ochoa Yeheng V. Liu Yii-Der Ida Chen Gerald Reaven | 2013 | Diabetes Care2013，，10： | 1 |
| 5 | 疫情后 配送中心重启之道显示文摘与大多数企业一样,受新冠肺炎疫情影响,物流企业的订单履行和配送中心无法简单地通过“打开开关”就能恢复正常运营。对于业务网络跨州或跨国的公司来说,重新开放的复杂性更大。其中,配送中心重新开放需要一套严谨的方法,辅以数据和逻辑分析,以及一些能够充分利用现有技术的创造性思维。 | Ron Grove Alice(翻译) | 2020 | 物流时代周刊2020，，9： | 0 |
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